Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Irene, Sebastianutto"'
Publikováno v:
Neurobiology of Disease, Vol 105, Iss , Pp 117-131 (2017)
Striatal neurons forming the indirect pathway (iSPNs) are particularly vulnerable in Huntington's disease (HD). In this study we set out to investigate morphological and physiological alterations of iSPNs in two mouse models of HD with relatively slo
Externí odkaz:
https://doaj.org/article/4022ca194a44473993a15705fb31d781
Publikováno v:
Neurobiology of Disease, Vol 96, Iss , Pp 156-170 (2016)
Rodent models of l-DOPA-induced dyskinesia (LID) are essential to investigate pathophysiological mechanisms and treatment options. Ratings of abnormal involuntary movements (AIMs) are used to capture both qualitative and quantitative features of dysk
Externí odkaz:
https://doaj.org/article/24b856d0ecaf45e6a19841878c292186
Publikováno v:
Journal of Clinical Investigation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::ba6fa4dec2568b15569da8c43c9aadcc
Autor:
Cecilia Lundberg, Marcus Lockowandt, L. Zanetti, Irene Sebastianutto, M. A. Cenci, Ludivine S. Breger, Tim Fieblinger, Luis Quintino
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports
Scientific Reports
Dendritic regression of striatal spiny projection neurons (SPNs) is a pathological hallmark of Parkinson’s disease (PD). Here we investigate how chronic dopamine denervation and dopamine replacement with L-DOPA affect the morphology and physiology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a6ea477a82a015ac29aff102013929
http://link.springer.com/article/10.1038/s41598-018-28273-5
http://link.springer.com/article/10.1038/s41598-018-28273-5
Publikováno v:
Neurobiology of Disease, Vol 96, Iss, Pp 156-170 (2016)
Rodent models of l-DOPA-induced dyskinesia (LID) are essential to investigate pathophysiological mechanisms and treatment options. Ratings of abnormal involuntary movements (AIMs) are used to capture both qualitative and quantitative features of dysk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e834435653dfae472f0866423ab6b76
https://doi.org/10.1016/j.nbd.2016.09.001
https://doi.org/10.1016/j.nbd.2016.09.001
Autor:
Irene, Sebastianutto, Elise, Goyet, Laura, Andreoli, Joan, Font-Ingles, David, Moreno-Delgado, Nathalie, Bouquier, Céline, Jahannault-Talignani, Enora, Moutin, Luisa, Di Menna, Natallia, Maslava, Jean-Philippe, Pin, Laurent, Fagni, Ferdinando, Nicoletti, Fabrice, Ango, M Angela, Cenci, Julie, Perroy
Publikováno v:
J Clin Invest
Dopamine receptor D1 modulates glutamatergic transmission in cortico-basal ganglia circuits and represents a major target of L-DOPA therapy in Parkinson’s disease. Here we show that D1 and metabotropic glutamate type 5 (mGlu5) receptors can form pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::249340453eee375f8b8fb47f956905f4
https://pubmed.ncbi.nlm.nih.gov/32039920
https://pubmed.ncbi.nlm.nih.gov/32039920
Autor:
M. A. Cenci, Irene Sebastianutto
Publikováno v:
Current opinion in pharmacology. 38
Parkinson's disease (PD) is a neurodegenerative disorder characterized by typical motor features that result from dopamine (DA) depletion in the striatum. DA replacement therapy with L-DOPA is the most efficacious symptomatic treatment, but causes co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1d370a00984c481592303bde830fc7e
https://pubmed.ncbi.nlm.nih.gov/29625424
https://pubmed.ncbi.nlm.nih.gov/29625424
Autor:
Sabina Sandberg, David Engblom, Tim Fieblinger, M. Angela Cenci, Irene Sebastianutto, Cristina Alcacer, Zisis Bimpisidis, Natallia Maslava
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience; 34(13), pp 4728-4740 (2014)
In animal models of Parkinson′s disease, striatal overactivation of ERK1/2 via dopamine (DA) D1 receptors is the hallmark of a supersensitive molecular response associated with dyskinetic behaviors. Here we investigate the pathways involved in D1 r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9355f756b13258470d4c744b95d94165
https://doi.org/10.1523/jneurosci.2702-13.2014
https://doi.org/10.1523/jneurosci.2702-13.2014
Autor:
Tim Fieblinger, Irene Sebastianutto, Cristina Alcacer, M. A. Cenci, Laura Andreoli, Johan Jakobsson
Publikováno v:
The Journal of clinical investigation. 127(2)
Parkinson's disease (PD) patients experience loss of normal motor function (hypokinesia), but can develop uncontrollable movements known as dyskinesia upon treatment with L-DOPA. Poverty or excess of movement in PD has been attributed to overactivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc880f14d22b419d468cafcfc861266b
https://pubmed.ncbi.nlm.nih.gov/28112685
https://pubmed.ncbi.nlm.nih.gov/28112685
Publikováno v:
Parkinsonism & Related Disorders. 22:e90
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a79955048cf5a814748bd6c9105d28ac
https://doi.org/10.1016/j.parkreldis.2015.10.189
https://doi.org/10.1016/j.parkreldis.2015.10.189