Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Irene, Lecker"'
Publikováno v:
Neuroscience. 464:126-132
The establishment and maintenance of strong affiliative relationships is fundamental for group cohesion and crucial for overall individual well-being. Empathy is considered a critical process for promoting attachment and the long-term stability of so
Autor:
Massieh Moayedi, Abigail J. D’Souza, Sarah F. Rosen, Helena Fetter Filippini, Anastassia Dokova, Vassilia Michailidis, Igor Vukobradovic, Toni-Lee Sterley, Paul D. Whissell, Wai-Jane Virginia Lee, John R. Matyas, Maian Christine Pham, Hantao Zhang, Jeff Biernaskie, Chereen Collymore, David N. Dubins, Ingita Patel, Loren J. Martin, Chulmin Cho, Hayley Crawhall-Duk, Irene Lecker, Jo Anne Stratton, Hendrik W. Steenland, Robert P. Bonin, Jeffrey S. Mogil, Jaideep S. Bains, Ann M. Flenniken, Jerry Li, Alexandr Bezginov, Maham Zain, Megan Valencia
Publikováno v:
Pain
Supplemental Digital Content is Available in the Text. Cage-lid hanging behavior is impaired by sustained pain in mice and can be used as an ethologically valid and translationally relevant pain outcome measure.
The development of new analgesic
The development of new analgesic
Autor:
Beverley A. Orser, Gang Lei, Paul D. Whissell, Michael Dewar, Irene Lecker, Dian-Shi Wang, Andrew J Baker, Heping Sheng, Alejandro Fernandez-Escobar, Nathan K. Chan, Sinziana Avramescu, Shahin Khodaei
Publikováno v:
Critical Care Medicine. 48:533-544
OBJECTIVES Cognitive deficits after traumatic brain injury are a leading cause of disability worldwide, yet no effective pharmacologic treatments exist to improve cognition. Traumatic brain injury increases proinflammatory cytokines, which trigger ex
Autor:
Dian-Shi Wang, Agnieszka A. Zurek, Irene Lecker, Jieying Yu, Armen M. Abramian, Sinziana Avramescu, Paul A. Davies, Stephen J. Moss, Wei-Yang Lu, Beverley A. Orser
Publikováno v:
Cell Reports, Vol 2, Iss 3, Pp 488-496 (2012)
Systemic inflammation causes learning and memory deficits through mechanisms that remain poorly understood. Here, we studied the pathogenesis of memory loss associated with inflammation and found that we could reverse memory deficits by pharmacologic
Externí odkaz:
https://doaj.org/article/1ebcc842bc7d408ba3898da64e571c56
Autor:
Alejandro Fernandez-Escobar, Jeremy M Sivak, C. Justin Lee, Amy J. Ramsey, Junhui Wang, Beverley A. Orser, Nathan K. Chan, Junsung Woo, Dian Shi Wang, Darren Chan, Sinziana Avramescu, Robert P. Bonin, Fariya Mostafa, Irene Lecker, Yu-Feng Xie, Gang Lei, Kirusanthy Kaneshwaran
Publikováno v:
Anesthesiology. 129:477-489
What We Already Know about This Topic What This Article Tells Us That Is New Background Postoperative delirium is associated with poor long-term outcomes and increased mortality. General anesthetic drugs may contribute to delirium because they increa
Autor:
Irene Lecker, Chereen Collymore, Robert P. Bonin, Mary Loka, Loren J. Martin, Christine Pham, Matthew Danesh, Chulmin Cho, Paige Urban, Vassilia Michailidis, David Hanwell
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-1 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Publikováno v:
Anesthesiology. 127:89-97
Background The antifibrinolytic drug tranexamic acid is structurally similar to the amino acid glycine and may cause seizures and myoclonus by acting as a competitive antagonist of glycine receptors. Glycine is an obligatory co-agonist of the N-methy
Autor:
Louis-Etienne Lorenzo, Agnieszka A. Zurek, Jimena Perez-Sanchez, Irene Lecker, Robert P. Bonin, Erica M. Bridgwater, Charalampos Labrakakis, Yves De Koninck, Beverley A. Orser
Publikováno v:
Journal of Neuroscience Research. 95:1307-1318
Neuronal inhibition mediated by GABAA receptors constrains nociceptive processing in the spinal cord, and loss of GABAergic inhibition can produce allodynia and hyperalgesia. Extrasynaptic α5 subunit-containing GABAA receptors (α5GABAA Rs) generate
Autor:
Paul D. Whissell, William T. H. To, Richard L. Horner, Sinziana Avramescu, Lia Mesbah-Oskui, Dian-Shi Wang, Irene Lecker, Beverley A. Orser, Antonello Penna
Publikováno v:
Anesthesiology. 124:417-427
BackgroundCritically ill patients with severe inflammation often exhibit heightened sensitivity to general anesthetics; however, the underlying mechanisms remain poorly understood. Inflammation increases the number of γ-aminobutyric acid type A (GAB
Autor:
Sinziana Avramescu, Beverley A. Orser, Dian-Shi Wang, C. David Mazer, Paul D. Whissell, Irene Lecker
Publikováno v:
Annals of Neurology
Antifibrinolytic drugs are routinely used worldwide to reduce the bleeding that results from a wide range of hemorrhagic conditions. The most commonly used antifibrinolytic drug, tranexamic acid, is associated with an increased incidence of postopera