Identification and Preclinical Development of a 2,5,6-Trisubstituted Fluorinated Pyridine Derivative as a Radioligand for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors

Autor: Francesco Spinelli, Pal Pacher, Kenneth Atz, Dieter Muri, Linjing Mu, Hazem Ahmed, Adrienne Müller Herde, Christoph Ullmer, Martin Binder, Thomas Johannes Woltering, Hans Iding, Luca Gobbi, Julian Kretz, Ahmed Haider, Markus Weber, Markus Bürkler, Uwe Grether, Roger Schibli, Simon M. Ametamey, Michael Honer, Andreas Brink, Claudia Keller, Irene Knuesel, Christian Bartelmus

Publikováno v: Journal of Medicinal Chemistry. 63:10287-10306

Despite the broad implications of the cannabinoid type 2 receptor (CB2) in neuroinflammatory processes, a suitable CB2-targeted probe is currently lacking in clinical routine. In this work, we synthesized 15 fluorinated pyridine derivatives and teste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c71a1196506a42b7b5cde13030c4b1e
https://doi.org/10.1021/acs.jmedchem.0c00778

Evidence for effects of extracellular vesicles on physical, inflammatory, transcriptome and reward behaviour status in mice

Autor: Nagiua Cuomo-Haymour, Hannes Sigrist, Christian Ineichen, Giancarlo Russo, Ursina Nüesch, Felix Gantenbein, Luka Kulic, Irene Knuesel, Giorgio Bergamini, Christopher Robert Pryce

Publikováno v: International journal of molecular sciences, Basel : MDPI, 2022, vol. 23, no. 3, p. 195-208
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1028
International Journal of Molecular Sciences, 23 (3)
International Journal of Molecular Sciences, Vol 23, Iss 1028, p 1028 (2022)

Immune-inflammatory activation impacts extracellular vesicles (EVs), including their miRNA cargo. There is evidence for changes in the EV miRNome in inflammation-associated neuropsychiatric disorders. This mouse study investigated: (1) effects of sys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::183e93bb6ac6ecd21b1fab8247679618
https://repository.vu.lt/VU:ELABAPDB133193429&prefLang=en_US

Longitudinal Assessment of Amyloid Pathology in Transgenic ArcAβ Mice Using Multi-Parametric Magnetic Resonance Imaging.

Autor: Jan Klohs, Igna Wojtyna Politano, Andreas Deistung, Joanes Grandjean, Anna Drewek, Marco Dominietto, Ruth Keist, Ferdinand Schweser, Jürgen R Reichenbach, Roger M Nitsch, Irene Knuesel, Markus Rudin

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e66097 (2013)

Magnetic resonance imaging (MRI) can be used to monitor pathological changes in Alzheimer's disease (AD). The objective of this longitudinal study was to assess the effects of progressive amyloid-related pathology on multiple MRI parameters in transg

Externí odkaz: https://doaj.org/article/963e29b8b0b04cb3b12f44ceb5fa1a84

Evolution of a maternal immune activation (mIA) model in rats:early developmental effects

Autor: Varsha Mason, Patrick C McHugh, Maurizio Manca, Katie N. Murray, Michael K. Harte, Ben Grayson, Michelle E. Edye, Joanna C. Neill, Eric Prinssen, Reinmar Hager, Anthony C. Vernon, Victoria Fasolino, Joanna M. Oladipo, Irene Knuesel

Publikováno v: Murray, K N, Edye, M E, Manca, M, Vernon, A C, Oladipo, J M, Fasolino, V, Harte, M K, Mason, V, Grayson, B, McHugh, P C, Knuesel, I, Prinssen, E P, Hager, R & Neill, J C 2019, ' Evolution of a maternal immune activation (mIA) model in rats : early developmental effects ', Brain, Behavior, and Immunity, vol. 75, no. 0, pp. 48-59 . https://doi.org/10.1016/j.bbi.2018.09.005
Murray, K N, Edye, M E, Manca, M, Vernon, A C, Oladipo, J M, Fasolino, V, Harte, M K, Mason, V, Grayson, B, Mchugh, P C, Knuesel, I, Prinssen, E P, Hager, R & Neill, J C 2019, ' Evolution of a maternal immune activation (mIA) model in rats: Early developmental effects ', Brain, Behavior, and Immunity, vol. 75, pp. 48-59 . https://doi.org/10.1016/j.bbi.2018.09.005

Maternal immune activation (mIA) in rodents is rapidly emerging as a key model for neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. Here, we optimise a mIA model in rats, aiming to address certain limitations of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfd0788d57515ad8ac5dfeab3c54494
https://kclpure.kcl.ac.uk/ws/files/101174717/Evolution_of_a_maternal_immune_MURRAY_Firstonline12September2018_GREEN_AAM_CC_BY_NC_ND_.pdf

An In Vitro Bone Model to Investigate the Role of Triggering Receptor Expressed on Myeloid Cells-2 in Bone Homeostasis

Autor: Eva Mracsko, Dieter P. Reinhardt, Irene Knuesel, Arne Mehrkens, Ivan Martin, Nima Allafi, Eleonora Rossi, Adam Papadimitropoulos, Arnaud Scherberich

Publikováno v: Tissue engineering. Part C, Methods. 24(7)

Triggering receptor expressed on myeloid cells-2 (TREM-2), a transmembrane receptor expressed by macrophages, microglia, and osteoclasts (OCs), plays a protective role in late-onset Alzheimer Disease (AD). To validate TREM-2 as a therapeutic target i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df80bfcf0188c8bbec15aa4c26d8a57
https://pubmed.ncbi.nlm.nih.gov/29897015