Citrulline protects mice from experimental cerebral malaria by ameliorating hypoargininemia, urea cycle changes and vascular leak.

Autor: Irene Gramaglia, Joyce Velez, Yu-Sun Chang, Wilson Caparros-Wanderley, Valery Combes, Georges Grau, Monique F Stins, Henri C van der Heyde

Publikováno v: PLoS ONE, Vol 14, Iss 3, p e0213428 (2019)

Clinical and model studies indicate that low nitric oxide (NO) bioavailability due in part to profound hypoargininemia contributes to cerebral malaria (CM) pathogenesis. Protection against CM pathogenesis may be achieved by altering the diet before i

Externí odkaz: https://doaj.org/article/cfd0cdb2b1e14cb18c40271e19758a88

Platelets activate a pathogenic response to blood-stage Plasmodium infection but not a protective immune response

Autor: Valery Combes, Joyce Velez, Melanie Wree, Irene Gramaglia, Henri C. van der Heyde, Georges E. Grau

Publikováno v: Blood. 129:1669-1679

© 2017 by The American Society of Hematology. Clinical studies indicate that thrombocytopenia correlates with the development of severe falciparum malaria, suggesting that platelets either contribute to control of parasite replication, possibly as i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73fb54a2affd56e5624c91dc1351972f
https://doi.org/10.1182/blood-2016-08-733519

Thy-1 dependent uptake of mesenchymal stem cell-derived extracellular vesicles blocks myofibroblastic differentiation

Autor: James S. Hagood, Simon S. Wong, Shu Chien, Chunting Tan, Joy M. Chan, Tzu-Pin Shentu, Celia R. Espinoza, Mateja Cernelc-Kohan, Irene Gramaglia, Tse-Shun Huang, Henri C. van der Heyde

Publikováno v: Shentu, Tzu-Pin; Huang, Tse-Shun; Cernelc-Kohan, Mateja; Chan, Joy; Wong, Simon S; Espinoza, Celia R; et al.(2017). Thy-1 dependent uptake of mesenchymal stem cell-derived extracellular vesicles blocks myofibroblastic differentiation.. Scientific reports, 7(1), 18052. doi: 10.1038/s41598-017-18288-9. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/6522p939
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports
Scientific reports, vol 7, iss 1

Bone marrow-derived mesenchymal stem cells (MSC) have been promoted for multiple therapeutic applications. Many beneficial effects of MSCs are paracrine, dependent on extracellular vesicles (EVs). Although MSC-derived EVs (mEVs) are beneficial for ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738e9979b89fc39cac86b0b2de8f42bc
http://www.escholarship.org/uc/item/6522p939

Elevation of Intracellular Cyclic AMP in Alloreactive CD4+ T Cells Induces Alloantigen-Specific Tolerance That Can Prevent GVHD Lethality In Vivo

Autor: Matthew J. O'Shaughnessy, Bruce R. Blazar, Thomas Grader-Beck, Patricia A. Taylor, Zong Ming Chen, Vassiliki A. Boussiotis, Angela Panoskaltsis-Mortari, Christine Vogtenhuber, Ed Palmer, Irene Gramaglia

Publikováno v: Biology of Blood and Marrow Transplantation. 13:530-542

Cyclic AMP (cAMP) is an important negative regulator of T cell activation, and an increased level of cAMP is associated with T cell hyporesponsiveness in vitro. We sought to determine whether elevating intracellular cAMP levels ex vivo in alloreactiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f842079986e8e4a18e8104afe9d4e7
https://doi.org/10.1016/j.bbmt.2007.01.071

Nitric oxide bioavailability in malaria

Autor: Marcos Intaglietta, Henri C. van der Heyde, John A. Frangos, Irene Gramaglia, Peter Sobolewski

Publikováno v: Trends in Parasitology. 21:415-422

Rational development of adjunct or anti-disease therapy for severe Plasmodium falciparum malaria requires cellular and molecular definition of malarial pathogenesis. Nitric oxide (NO) is a potential target for such therapy but its role during malaria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3039bd8218979d320ac8cb019910d8b
https://doi.org/10.1016/j.pt.2005.07.002