Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Irene, Galiana"'
1
Akademický článek
A renal clearable fluorogenic probe for in vivo β-galactosidase activity detection during aging and senolysis
Autor: Sara Rojas-Vázquez, Beatriz Lozano-Torres, Alba García-Fernández, Irene Galiana, Ana Perez-Villalba, Pablo Martí-Rodrigo, M. José Palop, Marcia Domínguez, Mar Orzáez, Félix Sancenón, Juan F. Blandez, Isabel Fariñas, Ramón Martínez-Máñez
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Accumulation of senescent cells with age leads to tissue dysfunction and related diseases. Their detection in vivo still constitutes a challenge in aging research. We describe the generation of a fluorogenic probe (sulfonic-Cy7Gal) based on
Externí odkaz: https://doaj.org/article/1498936e271e4859a089a88d0502ed20
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2
Akademický článek
A versatile drug delivery system targeting senescent cells
Autor: Daniel Muñoz‐Espín, Miguel Rovira, Irene Galiana, Cristina Giménez, Beatriz Lozano‐Torres, Marta Paez‐Ribes, Susana Llanos, Selim Chaib, Maribel Muñoz‐Martín, Alvaro C Ucero, Guillermo Garaulet, Francisca Mulero, Stephen G Dann, Todd VanArsdale, David J Shields, Andrea Bernardos, José Ramón Murguía, Ramón Martínez‐Máñez, Manuel Serrano
Publikováno v: EMBO Molecular Medicine, Vol 10, Iss 9, Pp 1-18 (2018)
Abstract Senescent cells accumulate in multiple aging‐associated diseases, and eliminating these cells has recently emerged as a promising therapeutic approach. Here, we take advantage of the high lysosomal β‐galactosidase activity of senescent
Externí odkaz: https://doaj.org/article/d67df62499c14123a2c81e830cc433e4
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3
Preclinical antitumor efficacy of senescence-inducing chemotherapy combined with a nanoSenolytic
Autor: Irene Galiana, Mar Orzáez, Mónica Sancho, María Alfonso, Viviana Bisbal, Beatriz Lozano-Torres, Ramón Martínez-Máñez, Manuel Serrano, Andrea Bernardos
Publikováno v: RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname
[EN] The induction of senescence produces a stable cell cycle arrest in cancer cells, thereby inhibiting tumor growth; however, the incomplete immune cell-mediated clearance of senescent cells may favor tumor relapse, limiting the long-term anti-tumo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f4f15c2b94a49fd019c4e6cc50009a
https://doi.org/10.1016/j.jconrel.2020.04.045
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4
Combination of palbociclib with navitoclax based-therapies enhances in vivo antitumoral activity in triple-negative breast cancer
Autor: Alejandra Estepa-Fernández, Alba García-Fernández, Araceli Lérida-Viso, Juan F. Blandez, Irene Galiana, Félix Sancenon-Galarza, Mar Orzáez, Ramón Martínez-Máñez
Publikováno v: Pharmacological Research. 187:106628
Triple-negative breast cancer (TNBC) is a very aggressive subtype of breast cancer with a poor prognosis and limited effective therapeutic options. Induction of senescence, arrest of cell proliferation, has been explored as an effective method to lim
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e51c99ae4c5a9837abf28b9acd430b
https://doi.org/10.1016/j.phrs.2022.106628
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5
A renal clearable fluorogenic probe for in vivo detection of cellular senescence
Autor: Isabel Fariñas, Irene Galiana, Juan F. Blandez, Beatriz Lozano-Torres, Alba García-Fernández, Sara Rojas-Vázquez, Ramón Martínez-Máñez, Mar Orzáez, Félix Sancenón
There is a growing need for non-invasive, cheap, and versatile diagnostic methods and the development of low-cost point-of-care assays constitutes a potential solution. Here, we describe the design of a renal clearable fluorogenic probe (Cy7Gal) whic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1e42babf65249fc220d71bffdab4b4f
https://doi.org/10.21203/rs.3.rs-418261/v1
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6
A Two-Photon Probe Based on Naphthalimide-Styrene Fluorophore for the
Autor: Beatriz, Lozano-Torres, Juan F, Blandez, Irene, Galiana, José A, Lopez-Dominguez, Miguel, Rovira, Marta, Paez-Ribes, Estela, González-Gualda, Daniel, Muñoz-Espín, Manuel, Serrano, Félix, Sancenón, Ramón, Martínez-Máñez
Publikováno v: Analytical Chemistry
Cellular senescence is a state of stable cell cycle arrest that can negatively affect the regenerative capacities of tissues and can contribute to inflammation and the progression of various aging-related diseases. Advances in the in vivo detection o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d8bc6a5add68290a66a8f0c3ee311a39
https://pubmed.ncbi.nlm.nih.gov/33502178
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7
A Two-Photon Probe Based on Naphthalimide-Styrene Fluorophore for the In Vivo Tracking of Cellular Senescence
Autor: Irene Galiana, Estela González-Gualda, Félix Sancenón, Marta Paez-Ribes, Ramón Martínez-Máñez, Beatriz Lozano-Torres, Manuel Serrano, Miguel Rovira, Daniel Muñoz-Espín, Juan F. Blandez, Jose Alberto Lopez-Dominguez
Publikováno v: Analytical Chemistry
Dipòsit Digital de la UB
Universidad de Barcelona
ANALYTICAL CHEMISTRY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
[EN] Cellular senescence is a state of stable cell cycle arrest that can negatively affect the regenerative capacities of tissues and can contribute to inflammation and the progression of various aging-related diseases. Advances in the in vivo detect
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcebf90fe7b83e3080971be06610b7a8
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8
Real-Time In Vivo Detection of Cellular Senescence through the Controlled Release of the NIR Fluorescent Dye Nile Blue
Autor: Ramón Martínez-Máñez, Alba García-Fernández, Beatriz Lozano-Torres, Irene Galiana, Juan F. Blandez, Félix Sancenón, María Alfonso, Mar Orzáez, María Dolores Marcos
Publikováno v: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
[EN] In vivo detection of cellular senescence is accomplished by using mesoporous silica nanoparticles loaded with the NIR-FDA approved Nile blue (NB) dye and capped with a galactohexasaccharide (S3). NB emission at 672 nm is highly quenched inside S
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f3e34a2907c17dcc0391854e158b83
https://pubmed.ncbi.nlm.nih.gov/32416002
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10
Desarrollo de nuevos nanodispositivos terapéuticos aplicados al tratamiento de enfermedades relacionadas con procesos de senescencia
Autor: Irene Galiana Guillem
Publikováno v: RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname
[ES] La presente tesis doctoral, titulada “Desarrollo de nuevos nanodispositivos terapéuticos aplicados al tratamiento de enfermedades relacionadas con procesos de senescencia”, está centrada en el diseño, preparación, caracterización y eval
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7403721d493b165500f636b97c17061e
http://hdl.handle.net/10251/151950
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