Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Irene, Farabella"'
Autor:
Hannah L. Harris, Huiya Gu, Moshe Olshansky, Ailun Wang, Irene Farabella, Yossi Eliaz, Achyuth Kalluchi, Akshay Krishna, Mozes Jacobs, Gesine Cauer, Melanie Pham, Suhas S. P. Rao, Olga Dudchenko, Arina Omer, Kiana Mohajeri, Sungjae Kim, Michael H. Nichols, Eric S. Davis, Dimos Gkountaroulis, Devika Udupa, Aviva Presser Aiden, Victor G. Corces, Douglas H. Phanstiel, William Stafford Noble, Guy Nir, Michele Di Pierro, Jeong-Sun Seo, Michael E. Talkowski, Erez Lieberman Aiden, M. Jordan Rowley
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Nuclear compartments are prominent features of 3D chromatin organization, but sequencing depth limitations have impeded investigation at ultra fine-scale. CTCF loops are generally studied at a finer scale, but the impact of looping on proxim
Externí odkaz:
https://doaj.org/article/273c83ceac55444f8d76b4044e6d0017
Autor:
Roser Vilarrasa-Blasi, Paula Soler-Vila, Núria Verdaguer-Dot, Núria Russiñol, Marco Di Stefano, Vicente Chapaprieta, Guillem Clot, Irene Farabella, Pol Cuscó, Marta Kulis, Xabier Agirre, Felipe Prosper, Renée Beekman, Silvia Beà, Dolors Colomer, Hendrik G. Stunnenberg, Ivo Gut, Elias Campo, Marc A. Marti-Renom, José Ignacio Martin-Subero
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The dynamics of genome architecture during human cell differentiation and upon neoplastic transformation remain poorly characterized. Here, the authors integrate in situ Hi-C and nine additional omic layers to characterize the dynamic changes in 3D g
Externí odkaz:
https://doaj.org/article/5b3e5737815642a5840183e2effa2f69
Autor:
Marco Di Stefano, Ralph Stadhouders, Irene Farabella, David Castillo, François Serra, Thomas Graf, Marc A. Marti-Renom
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Regulation of chromosome structure plays essential roles in many nuclear processes. Here, the authors present TADdyn, a tool that integrates time-course 3C data, restraint-based modelling, and molecular dynamics to simulate the structural rearrangeme
Externí odkaz:
https://doaj.org/article/3ccb8204b8974088a007e811db572305
Autor:
Guy Nir, Irene Farabella, Cynthia Pérez Estrada, Carl G Ebeling, Brian J Beliveau, Hiroshi M Sasaki, S Dean Lee, Son C Nguyen, Ruth B McCole, Shyamtanu Chattoraj, Jelena Erceg, Jumana AlHaj Abed, Nuno M C Martins, Huy Q Nguyen, Mohammed A Hannan, Sheikh Russell, Neva C Durand, Suhas S P Rao, Jocelyn Y Kishi, Paula Soler-Vila, Michele Di Pierro, José N Onuchic, Steven P Callahan, John M Schreiner, Jeff A Stuckey, Peng Yin, Erez Lieberman Aiden, Marc A Marti-Renom, C-Ting Wu
Publikováno v:
PLoS Genetics, Vol 14, Iss 12, p e1007872 (2018)
Chromosome organization is crucial for genome function. Here, we present a method for visualizing chromosomal DNA at super-resolution and then integrating Hi-C data to produce three-dimensional models of chromosome organization. Using the super-resol
Externí odkaz:
https://doaj.org/article/cf552eea66d7469391f82a3f33fd4b3e
Autor:
Kimberley M. Reid, Robert Spaull, Smrithi Salian, Katy Barwick, Esther Meyer, Juan Zhen, Hiromi Hirata, Diba Sheipouri, Hind Benkerroum, Kathleen M. Gorman, Apostolos Papandreou, Michael A. Simpson, Yoshinobu Hirano, Irene Farabella, Maya Topf, Detelina Grozeva, Keren Carss, Martin Smith, Hardev Pall, Peter Lunt, Susanna De Gressi, Erik‐Jan Kamsteeg, Tobias B. Haack, Lucinda Carr, Rita Guerreiro, Jose Bras, Eamonn R. Maher, Richard H. Scott, Robert J. Vandenberg, F. Lucy Raymond, Wui K. Chong, Sniya Sudhakar, Kshitij Mankad, Maarten E. Reith, Philippe M. Campeau, Robert J. Harvey, Manju A. Kurian
Publikováno v:
Reid, K M, Spaull, R, Salian, S, Barwick, K, Meyer, E, Zhen, J, Hirata, H, Sheipouri, D, Benkerroum, H, Gorman, K M, Papandreou, A, Simpson, M A, Hirano, Y, Farabella, I, Topf, M, Grozeva, D, Carss, K, Smith, M, Pall, H, Lunt, P, Gressi, S D, Kamsteeg, EJ, Haack, T B, Carr, L, Guerreiro, R, Bras, J, Maher, E R, Scott, R H, Vandenberg, R J, Raymond, F L, Chong, W K, Sudhakar, S, Mankad, K, Reith, M E, Campeau, P M, Harvey, R J & Kurian, M A 2022, ' MED27, SLC6A7, and MPPE1 Variants in a Complex Neurodevelopmental Disorder with Severe Dystonia ', Movement Disorders, vol. 37, no. 10, pp. 2139-2146 . https://doi.org/10.1002/mds.29147
BackgroundDespite advances in next generation sequencing technologies, the identification of variants of uncertain significance (VUS) can often hinder definitive diagnosis in patients with complex neurodevelopmental disorders.ObjectiveThe objective o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae6a3f384902b53907c2243d415fc8f1
https://orca.cardiff.ac.uk/id/eprint/151492/1/mds.29147.pdf
https://orca.cardiff.ac.uk/id/eprint/151492/1/mds.29147.pdf
Autor:
Irene Farabella, Thieng Pham, Nadine S Henderson, Sebastian Geibel, Gilles Phan, David G Thanassi, Anne H Delcour, Gabriel Waksman, Maya Topf
Publikováno v:
eLife, Vol 5 (2016)
Externí odkaz:
https://doaj.org/article/930df1e2c99440c68394abd21d1b9f94
Autor:
Natalya Lukoyanova, Stephanie C Kondos, Irene Farabella, Ruby H P Law, Cyril F Reboul, Tom T Caradoc-Davies, Bradley A Spicer, Oded Kleifeld, Daouda A K Traore, Susan M Ekkel, Ilia Voskoboinik, Joseph A Trapani, Tamas Hatfaludi, Katherine Oliver, Eileen M Hotze, Rodney K Tweten, James C Whisstock, Maya Topf, Helen R Saibil, Michelle A Dunstone
Publikováno v:
PLoS Biology, Vol 13, Iss 2, p e1002049 (2015)
Membrane attack complex/perforin-like (MACPF) proteins comprise the largest superfamily of pore-forming proteins, playing crucial roles in immunity and pathogenesis. Soluble monomers assemble into large transmembrane pores via conformational transiti
Externí odkaz:
https://doaj.org/article/61da81d52f214c008c291f4ba889cd9a
Autor:
Carl Leung, Natalya V Dudkina, Natalya Lukoyanova, Adrian W Hodel, Irene Farabella, Arun P Pandurangan, Nasrin Jahan, Mafalda Pires Damaso, Dino Osmanović, Cyril F Reboul, Michelle A Dunstone, Peter W Andrew, Rana Lonnen, Maya Topf, Helen R Saibil, Bart W Hoogenboom
Publikováno v:
eLife, Vol 4 (2015)
Externí odkaz:
https://doaj.org/article/3ccb4083d8e948e290b3b3a5965a0e9c
Autor:
Carl Leung, Natalya V Dudkina, Natalya Lukoyanova, Adrian W Hodel, Irene Farabella, Arun P Pandurangan, Nasrin Jahan, Mafalda Pires Damaso, Dino Osmanović, Cyril F Reboul, Michelle A Dunstone, Peter W Andrew, Rana Lonnen, Maya Topf, Helen R Saibil, Bart W Hoogenboom
Publikováno v:
eLife, Vol 3 (2014)
Membrane attack complex/perforin/cholesterol-dependent cytolysin (MACPF/CDC) proteins constitute a major superfamily of pore-forming proteins that act as bacterial virulence factors and effectors in immune defence. Upon binding to the membrane, they
Externí odkaz:
https://doaj.org/article/95f4b1baef534ae3afce743c4f6eaf48
Autor:
Jörg Morf, Luis Felipe Jiménez-García, Steven W. Wingett, Marc A. Marti-Renom, Frank F Craig, Mayra Furlan-Magaril, Liu Xin, Jonathan Cairns, Simon Andrews, Simon Walker, Anne Segonds-Pichon, Irene Farabella, Peter Fraser
Publikováno v:
Nature Biotechnology. 37:793-802
The global, three-dimensional organization of RNA molecules in the nucleus is difficult to determine using existing methods. Here we introduce Proximity RNA-seq, which identifies colocalization preferences for pairs or groups of nascent and fully tra