Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Irena Trbojević-Akmačić"'
Autor:
Marina Kljaković-Gašpić Batinjan, Tea Petrović, Frano Vučković, Irzal Hadžibegović, Barbara Radovani, Ivana Jurin, Lovorka Đerek, Eva Huljev, Alemka Markotić, Ivica Lukšić, Irena Trbojević-Akmačić, Gordan Lauc, Ivan Gudelj, Rok Čivljak
Publikováno v:
Engineering, Vol 26, Iss , Pp 54-62 (2023)
The essential role of immunoglobulin G (IgG) in immune system regulation and combatting infectious diseases cannot be fully recognized without an understanding of the changes in its N-glycans attached to the asparagine 297 of the fragment crystalliza
Externí odkaz:
https://doaj.org/article/f551fb25a4dc417181bd37d173bbffe6
Autor:
Julija Jurić, Hongli Peng, Manshu Song, Frano Vučković, Jelena Šimunović, Irena Trbojević-Akmačić, Youxin Wang, Jiaonan Liu, Qing Gao, Hao Wang, Qiaoyun Chu, Marija Pezer, Wei Wang, Gordan Lauc
Publikováno v:
Engineering, Vol 26, Iss , Pp 108-118 (2023)
Immunoglobulin G (IgG) is the most abundant plasma glycoprotein and a prominent humoral immune mediator. Glycan composition affects the affinity of IgG to ligands and consequent immune responses. The modification of IgG N-glycosylation is considered
Externí odkaz:
https://doaj.org/article/256dfb1a547d4d71a08f80f6a427369e
Autor:
Irena Trbojević-Akmačić, Frano Vučković, Tea Pribić, Marija Vilaj, Urh Černigoj, Jana Vidič, Jelena Šimunović, Agnieszka Kępka, Ivana Kolčić, Lucija Klarić, Mislav Novokmet, Maja Pučić-Baković, Erdmann Rapp, Aleš Štrancar, Ozren Polašek, James F. Wilson, Gordan Lauc
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
A large-scale comparative study in two human populations analyzes human plasma transferrin and immunoglobulin G (IgG) N-glycosylation profiles and their association with age, sex, and various biochemical and physiological traits.
Externí odkaz:
https://doaj.org/article/0fd38750071a425299f347703d4524e0
Autor:
Alessia Visconti, Niccolò Rossi, Helena Deriš, Karla A Lee, Maja Hanić, Irena Trbojević-Akmačić, Andrew M. Thomas, Laura A. Bolte, Johannes R. Björk, Jahlisa S. Hooiveld-Noeken, Ruth Board, Mark Harland, Julia Newton-Bishop, Mark Harries, Joseph J. Sacco, Paul Lorigan, Heather M. Shaw, Elisabeth G.E. de Vries, Rudolf S.N. Fehrmann, Rinse K. Weersma, Tim D. Spector, Paul Nathan, Geke A. P. Hospers, Peter Sasieni, Veronique Bataille, Gordan Lauc, Mario Falchi
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of melanoma and other cancers. However, no reliable biomarker of survival or response has entered the clinic to identify those patients with melanoma who are mo
Externí odkaz:
https://doaj.org/article/50b511b7f9af46e6993f096da9d33865
Autor:
Arianna Landini, Irena Trbojević-Akmačić, Pau Navarro, Yakov A. Tsepilov, Sodbo Z. Sharapov, Frano Vučković, Ozren Polašek, Caroline Hayward, Tea Petrović, Marija Vilaj, Yurii S. Aulchenko, Gordan Lauc, James F. Wilson, Lucija Klarić
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Post-translational modifications are known to diversify protein functions, but the effect of genetic variation on the modifications is not well known. Here, the authors find both shared and protein-specific genetic mechanisms regulating the glycosyla
Externí odkaz:
https://doaj.org/article/d167c21c42894802a81e0f889cd91ee4
Autor:
Maja Hanić, Frano Vučković, Helena Deriš, Claire Bewshea, Simeng Lin, James R. Goodhand, Tariq Ahmad, Irena Trbojević-Akmačić, Nicholas A. Kennedy, Gordan Lauc, PANTS Consortium
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 954 (2023)
Crohn’s disease (CD) is a chronic inflammation of the digestive tract that significantly impairs patients’ quality of life and well-being. Anti-TNF biologicals revolutionised the treatment of CD, yet many patients do not adequately respond to suc
Externí odkaz:
https://doaj.org/article/b18d46dadc5a4d579794ac102865802b
Autor:
Tea Petrović, Amrita Vijay, Frano Vučković, Irena Trbojević-Akmačić, Benjamin J. Ollivere, Damir Marjanović, Tamer Bego, Besim Prnjavorac, Lovorka Đerek, Alemka Markotić, Ivica Lukšić, Ivana Jurin, Ana M. Valdes, Irzal Hadžibegović, Gordan Lauc
Publikováno v:
EBioMedicine, Vol 81, Iss , Pp 104101- (2022)
Summary: Background: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes a respiratory illness named coronavirus disease 2019 (COVID-19), which is one of the main global health problems since 2019. Glycans attached to the Fc porti
Externí odkaz:
https://doaj.org/article/4a2921817f05471d8e7c530def4d8a37
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/b8689c4c6d90448f8e050b27a1073d6d
Autor:
Helena Deriš, Domagoj Kifer, Ana Cindrić, Tea Petrović, Ana Cvetko, Irena Trbojević-Akmačić, Ivana Kolčić, Ozren Polašek, Louise Newson, Tim Spector, Cristina Menni, Gordan Lauc
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103897- (2022)
Summary: Gonadal hormones affect immunoglobulin G (IgG) glycosylation, and the more proinflammatory IgG glycome composition might be one of the molecular mechanisms behind the increased proinflammatory phenotype in perimenopause. Using ultra-high-per
Externí odkaz:
https://doaj.org/article/85e9d0d3a95a4655b1cac2cde739efca
Autor:
Marija Klasić, Dora Markulin, Aleksandar Vojta, Ivana Samaržija, Ivan Biruš, Paula Dobrinić, Nicholas T. Ventham, Irena Trbojević-Akmačić, Mirna Šimurina, Jerko Štambuk, Genadij Razdorov, Nicholas A. Kennedy, Jack Satsangi, Ana M. Dias, Salome Pinho, Vito Annese, Anna Latiano, Renata D’Inca, IBD consortium, Gordan Lauc, Vlatka Zoldoš
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-14 (2018)
Abstract Background Many genome- and epigenome-wide association studies (GWAS and EWAS) and studies of promoter methylation of candidate genes for inflammatory bowel disease (IBD) have demonstrated significant associations between genetic and epigene
Externí odkaz:
https://doaj.org/article/ce02961e66a74e88a9665fdbec09eb1d