Effect of Food and a Proton-Pump Inhibitor on the Absorption of Encorafenib: An In Vivo–In Vitro–In Silico Approach

Autor: Joseph Piscitelli, Bart Hens, Irena Tomaszewska, Lance Wollenberg, Kevin Litwiler, Mark McAllister, Micaela Reddy

Publikováno v: Molecular Pharmaceutics. 20:2589-2599

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7db724340562bfa15a21f4d3b21d1f4
https://doi.org/10.1021/acs.molpharmaceut.3c00016

In Vitro Simulation of the Environment in the Upper Gastrointestinal Lumen After Drug Administration in the Fed State Using the TIM-1 System and Comparison With Luminal Data in Adults

Autor: Ronald Schilderink, Maria Vertzoni, Christina Pentafragka, Irena Tomaszewska, Susann Bellmann, Christos Reppas, Mans Minekus, Mark McAllister

Publikováno v: Journal of Pharmaceutical Sciences. 111:197-205

We evaluated the environment in TIM-1 luminal compartments using paracetamol and danazol solutions and suspensions and the fed state configuration. Data were compared with recently published data in healthy adults. TIM-1 experiments were performed wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51bd1e6a35d423f74f4f489537dcfe5
https://doi.org/10.1016/j.xphs.2021.10.010

Investigating the Impact of Crohn's Disease on the Bioaccessibility of a Lipid-Based Formulation with an in Vitro Dynamic Gastrointestinal Model

Autor: Inese Sarcevica, Angela Effinger, Nikoletta Fotaki, Caitriona M. O'Driscoll, Irena Tomaszewska, Kieran Lewis Smith, Mark R. Taylor, Steve Gomersall, Mark McAllister, Sam L Young, James C. Heaton

Publikováno v: Effinger, A, Mcallister, M, Tomaszewska, I, O'Driscoll, C M, Taylor, M, Gomersall, S, Heaton, J, Smith, K L, Sarcevica, I, Young, S L & Fotaki, N 2021, ' Investigating the Impact of Crohn's Disease on the Bioaccessibility of a Lipid-Based Formulation with an in Vitro Dynamic Gastrointestinal Model ', Molecular Pharmaceutics, vol. 18, no. 4, pp. 1530-1543 . https://doi.org/10.1021/acs.molpharmaceut.0c00807

The aim of the study was to investigate the impact of Crohn's disease (CD) on the performance of a lipid-based formulation of ciprofloxacin in a complex gastrointestinal simulator (TIM-1, TNO) and to compare the luminal environment in terms of bile s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddea159f4994cb317d69e9d32191aacd
https://purehost.bath.ac.uk/ws/files/220250193/Manuscript_TIM_1_ciprofloxacin_Dr_N_Fotaki_Accepted.pdf

Dissolution testing of modified release products with biorelevant media: An OrBiTo ring study using the USP apparatus III and IV

Autor: Karin Rosenblatt, Kelly Etherson, Mark McAllister, Jonathan Brown, Christos Reppas, Gerd-Michael Maier, Eva Karlsson, Nena Mistry, James Williams, Kieran Lewis Smith, Jennifer B. Dressman, Napoleon-Nikolaos Vrettos, Sarah Hanley, Yoshihiro Miyaji, Frank Karkossa, Fredrik Winge, Maria Vertzoni, Sandra Klein, Kerstin Julia Schäfer, Cord J. Andreas, Irena Tomaszewska

During the OrBiTo project, our knowledge on the gastrointestinal environment has improved substantially and biorelevant media composition have been refined. The aim of this study was to propose optimized biorelevant testing conditions for modified re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd541974b77026b322efccf32895101
https://publica.fraunhofer.de/handle/publica/265256

Validation of Dissolution Testing with Biorelevant Media: An OrBiTo Study

Autor: Jean-Luc Bruel, Lee Ashworth, Stefania Beato, Krista Ojala, Irena Tomaszewska, James Butler, Lukas Klumpp, Kerstin J. Frank, Uwe Muenster, Paul Hutchins, James Williams, René Holm, Kristina Wielockx, Philippe Berben, James Mann, Sanjaykumar Patel, Jennifer B. Dressman, Karin Rosenblatt, Michael Hofmann, Patrick Augustijns

Publikováno v: Molecular pharmaceutics. 14(12)

Dissolution testing with biorelevant media has become widespread in the pharmaceutical industry as a means of better understanding how drugs and formulations behave in the gastrointestinal tract. Until now, however, there have been few attempts to ga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec082fe0f11426fdc5a40d0beb9de0c
https://pubmed.ncbi.nlm.nih.gov/28737403