Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Irena Pekker"'
1
Akademický článek
Pan-cancer adaptive immune resistance as defined by the Tumor Inflammation Signature (TIS): results from The Cancer Genome Atlas (TCGA)
Autor: Patrick Danaher, Sarah Warren, Rongze Lu, Josue Samayoa, Amy Sullivan, Irena Pekker, Brett Wallden, Francesco M. Marincola, Alessandra Cesano
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-17 (2018)
Abstract The Tumor Inflammation Signature (TIS) is an investigational use only (IUO) 18-gene signature that measures a pre-existing but suppressed adaptive immune response within tumors. The TIS has been shown to enrich for patients who respond to th
Externí odkaz: https://doaj.org/article/b2cb84032e6c41d894a0979aff381d60
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2
Akademický článek
The making of a compound inflorescence in tomato and related nightshades.
Autor: Zachary B Lippman, Oded Cohen, John P Alvarez, Mohamad Abu-Abied, Irena Pekker, Ilan Paran, Yuval Eshed, Dani Zamir
Publikováno v: PLoS Biology, Vol 6, Iss 11, p e288 (2008)
Variation in the branching of plant inflorescences determines flower number and, consequently, reproductive success and crop yield. Nightshade (Solanaceae) species are models for a widespread, yet poorly understood, program of eudicot growth, where s
Externí odkaz: https://doaj.org/article/a70f3af2797b460ca1fcd55fe5ddd4c7
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3
Pan-cancer adaptive immune resistance as defined by the Tumor Inflammation Signature (TIS): results from The Cancer Genome Atlas (TCGA)
Autor: Rongze Lu, Sarah Warren, Josue Samayoa, Patrick Danaher, Amy Sullivan, Brett Wallden, Irena Pekker, Francesco M. Marincola, Alessandra Cesano
Publikováno v: Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-17 (2018)
The Tumor Inflammation Signature (TIS) is an investigational use only (IUO) 18-gene signature that measures a pre-existing but suppressed adaptive immune response within tumors. The TIS has been shown to enrich for patients who respond to the anti-PD
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace4b6a90ac9698383df7addb4e70429
https://doi.org/10.1186/s40425-018-0367-1
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4
Continuously tunable nucleic acid hybridization probes
Autor: Irena Pekker, David Zhang, Emily R Evans, Celine Ngouenet, Alessandro Pinto, Joseph M. Beechem, Lucia R. Wu, Juexiao Wang, John Z. Fang, Richard Kemble Boykin, Philippa J. Webster
Publikováno v: Nature methods
In silico designed nucleic acid probes and primers often fail to achieve favorable specificity and sensitivity tradeoffs on the first try, and iterative empirical sequence-based optimization is needed, particularly in multiplexed assays. Here, we pre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efa77b42d57e545f16469c1ea04267f
https://doi.org/10.1038/nmeth.3626
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7
Validating critical analytical variables of a multiplexed gene expression assay measuring tumor inflammation designed to predict response to anti-PD1 therapy
Autor: Patrick Danaher, Brett Wallden, Simina Popa, Xing Ren, Carl Schaper, Sean Ferree, Sarah E. Church, Irena Pekker, Naeem Dowidar, Celine Ngouenet, Amy Sullivan
Publikováno v: Journal of Clinical Oncology. 36:203-203
203 Background: The development and analytical performance of the Tumor Inflammation Signature (TIS) assay has been described previously. The TIS is an investigational use RNA expression assay on the nCounter Dx Analysis System, which is being evalua
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1e94295d99ad24bed84d7a3ef0ad878
https://doi.org/10.1200/jco.2018.36.5_suppl.203
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8
Co-ordinated regulation of flowering time, plant architecture and growth by FASCICULATE: the pepper orthologue of SELF PRUNING
Autor: Ilan Paran, Irena Pekker, Yelena Borovsky, Hadas Nahum, Yuval Eshed, Tomer Elitzur
Publikováno v: Journal of Experimental Botany
Wild peppers (Capsicum spp.) are either annual or perennial in their native habitat and their shoot architecture is dictated by their sympodial growth habit. To study shoot architecture in pepper, sympodial development is described in wild type and i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f48745a4ebb41f96e7089f98dae8af
https://doi.org/10.1093/jxb/ern334
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9
[Untitled]
Autor: Irena Pekker, Elisha Tel-Or, Ron Mittler
Publikováno v: Plant Molecular Biology. 49:429-438
Excess of free iron is thought to harm plant cells by enhancing the intracellular production of reactive oxygen intermediates (ROI). Cytosolic ascorbate peroxidase (cAPX) is an iron-containing, ROI-detoxifying enzyme induced in response to iron overl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f453f84ed8f755f45841c1dee50698d3
https://doi.org/10.1023/a:1015554616358
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10
Verification of the analytical performance of a molecular diagnostic for response to anti-PD1 therapy on the nCounter Dx Analysis System
Autor: Mingdong Liu, Afshin Mashadi-Hossein, Irena Pekker, Simina Popa, James Storhoff, Naeem Dowidar, Brett Wallden, Sean Ferree, Patrick Danaher, Matthew J. Marton, Celine Ngouenet, Amy Sullivan
Publikováno v: Journal of Clinical Oncology. 35:8-8
8 Background: Pembrolizumab is a humanized anti-PD1 antibody that is approved for use in advanced melanoma, recurrent or metastatic head and neck squamous cell carcinoma, and metastatic non-small-cell lung cancer. It has also shown clinical activity
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6432a7cc247d79b2c547082496fb1d5f
https://doi.org/10.1200/jco.2017.35.7_suppl.8
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