Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Irena Misiewicz‐Krzeminska"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Multiple myeloma is an incurable cancer that originates from antibody-producing plasma cells. It is characterized by an intrinsic ability to produce large amounts of immunoglobulin-like proteins. The high rate of synthesis makes myeloma cells depende
Externí odkaz:
https://doaj.org/article/8df778689d2f459c89dbea6af1746f26
Autor:
Ignacio J. Cardona-Benavides, Irena Misiewicz-Krzeminska, Elizabeta A. Rojas, Cristina De Ramón, Antonio Sanz-Solas, Isabel Isidro, Dalia Quwaider, Aida M. López-Guerrero, Myriam Cuadrado, María-José Calasanz, Laura Rosiñol, Joaquín Martínez-López, Jesús F. San Miguel, María-Victoria Mateos, Luis A. Corchete, Norma C. Gutiérrez
Publikováno v:
Haematologica, Vol 109, Iss 3 (2023)
Upregulation of a cyclin D gene determined by expression microarrays is an almost universal event in multiple myeloma (MM), but this finding has not been properly confirmed at the protein level. For this reason, we carried out a quantitative analysis
Externí odkaz:
https://doaj.org/article/d2fb4d2c2d1d4ba0898028202a445ac2
Autor:
Cristina De Ramón Sánchez, Elizabeta A Rojas, Irena Misiewicz-Krzeminska, Ignacio J Cardona-Benavides, Myriam Cuadrado, Isabel Isidro, Maria Jose Calasanz, Ramón García-Sanz, Laura Rosiñol Dachs, Joaquín Martinez-Lopez, Joan Baldé, Juan J Lahuerta, Jesus F San Miguel, Maria-Victoria Mateos, Luis A Corchete, Norma Carmen Gutierrez Gutierrez
Publikováno v:
HemaSphere, Vol 7, p e8080195 (2023)
Externí odkaz:
https://doaj.org/article/9697f7ca1f75463ba52bd9fa25cdbe17
Autor:
Ana-Alicia López-Iglesias, Ana B. Herrero, Marta Chesi, Laura San-Segundo, Lorena González-Méndez, Susana Hernández-García, Irena Misiewicz-Krzeminska, Dalia Quwaider, Montserrat Martín-Sánchez, Daniel Primo, Teresa Paíno, P. Leif Bergsagel, Thomas Mehrling, Marcos González-Díaz, Jesús F. San-Miguel, María-Victoria Mateos, Norma C. Gutiérrez, Mercedes Garayoa, Enrique M. Ocio
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-14 (2017)
Abstract Background Despite recent advances in the treatment of multiple myeloma (MM), the prognosis of most patients remains poor, and resistance to traditional and new drugs frequently occurs. EDO-S101 is a novel therapeutic agent conceived as the
Externí odkaz:
https://doaj.org/article/bfebf6dd497c42b797a071d86cc0e1d4
Autor:
Dalia Quwaider, Luis A. Corchete, Irena Misiewicz-Krzeminska, María E. Sarasquete, José J. Pérez, Patryk Krzeminski, Noemí Puig, María Victoria Mateos, Ramón García-Sanz, Ana B. Herrero, Norma C. Gutiérrez
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-12 (2017)
Abstract Background The B cell maturation process involves multiple steps, which are controlled by relevant pathways and transcription factors. The understanding of the final stages of plasma cell (PC) differentiation could provide new insights for t
Externí odkaz:
https://doaj.org/article/8c10825ddb1c4a2f8a9ac6c1204e58cd
Publikováno v:
Bio-Protocol, Vol 9, Iss 12 (2019)
Protein analysis in bone marrow samples from patients with multiple myeloma (MM) has been limited by the low concentration of proteins obtained after CD138+ cell selection. A novel approach based on capillary nano-immunoassay could make it possible t
Externí odkaz:
https://doaj.org/article/10dd855406444e1bb299d92cc04a8a08
Autor:
Elizabeta A. Rojas, Luis A. Corchete, Cristina De Ramón, Patryk Krzeminski, Dalia Quwaider, Ramón García‐Sanz, Joaquín Martínez‐López, Albert Oriol, Laura Rosiñol, Joan Bladé, Juan José Lahuerta, Jesús F. San Miguel, Marcos González, María Victoria Mateos, Jean‐Christophe Bourdon, Irena Misiewicz‐Krzeminska, Norma C. Gutiérrez
Publikováno v:
American Journal of Hematology
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Loss and/or mutation of the TP53 gene are associated with short survival in multiple myeloma, but the p53 landscape goes far beyond. At least 12 p53 protein isoforms have been identified as a result of a combination of alternative splicing, alternati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::448d1c6742796e670dabd12ef077016d
https://doi.org/10.1002/ajh.26507
https://doi.org/10.1002/ajh.26507
Autor:
Norma C. Gutiérrez, Irena Misiewicz-Krzeminska, Enrique M. Ocio, María Victoria Mateos, Ramón García-Sanz, Noemí Puig, Teresa Paíno, Francisco M. Codoñer, Juan F. Martínez-Blanch, Laura San-Segundo, Luis Antonio Corchete, Elizabeta A. Rojas
Purpose: The search for new drugs that control the continuous relapses of multiple myeloma is still required. Here, we report for the first time the potent antimyeloma activity of amiloride, an old potassium-sparing diuretic approved for the treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b71a1c69dd5251a0c0b27951409d091
https://doi.org/10.1158/1078-0432.c.6527100
https://doi.org/10.1158/1078-0432.c.6527100
Autor:
Norma C. Gutiérrez, Irena Misiewicz-Krzeminska, Enrique M. Ocio, María Victoria Mateos, Ramón García-Sanz, Noemí Puig, Teresa Paíno, Francisco M. Codoñer, Juan F. Martínez-Blanch, Laura San-Segundo, Luis Antonio Corchete, Elizabeta A. Rojas
Supplementary methods, tables and references.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d515e696cdacf42af360b9f309de40
https://doi.org/10.1158/1078-0432.22468941
https://doi.org/10.1158/1078-0432.22468941
Autor:
Norma C. Gutiérrez, Jesús F. San Miguel, Ramón García-Sanz, Isidro Sánchez-García, Juan Luis García, Abelardo Bárez, Fernando Escalante, Ana A. Martín, Rocío Corral, Elizabeta A. Rojas, Dalia Quwaider, Luis Antonio Corchete, Katarzyna Wiktorska, Patryk Krzeminski, Carolina Vicente-Dueñas, María E. Sarasquete, Irena Misiewicz-Krzeminska
Purpose: Dysregulation of one of the three D-cyclin genes has been observed in virtually all multiple myeloma tumors. The mechanisms by which CCND2 is upregulated in a set of multiple myeloma are not completely deciphered. We investigated the role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039086dd21044c01668adbea5ff1098f
https://doi.org/10.1158/1078-0432.c.6524546
https://doi.org/10.1158/1078-0432.c.6524546