Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Irena Markova"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Background and aimsRecent studies suggest that empagliflozin reduces total and cardiovascular mortality in both diabetic and nondiabetic subjects. Although the exact mechanism is unclear, it is understood to positively affect myocardial energetics, i
Externí odkaz:
https://doaj.org/article/fa2238b0f7a646cf9584cc6424377b21
Autor:
Martina Hüttl, Irena Markova, Denisa Miklánková, Iveta Zapletalova, Petr Kujal, Jan Šilhavý, Michal Pravenec, Hana Malinska
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background and aims: Low-grade chronic inflammation plays an important role in the pathogenesis of metabolic syndrome, type 2 diabetes and their complications. In this study, we investigated the effects of salsalate, a non-steroidal anti-inflammatory
Externí odkaz:
https://doaj.org/article/43d18ec3736b4092867a31a16cc3da06
Autor:
Rostislav Vecera, Martin Poruba, Martina Hüttl, Hana Malinska, Olena Oliyarnyk, Irena Markova, Zuzana Racova, Jan Soukop, Ludmila Kazdova
Publikováno v:
Current Issues in Molecular Biology, Vol 44, Iss 5, Pp 1889-1900 (2022)
The efficacy of fenofibrate in the treatment of hepatic steatosis has not been clearly demonstrated. In this study, we investigated the effects of fenofibrate and silymarin, administered as monotherapy and in combination to existing hepatic steatosis
Externí odkaz:
https://doaj.org/article/b82668e3dd6848b6afbb2ca9d5af9fdc
Autor:
Hana Malinska, Marta Klementová, Michaela Kudlackova, Jiri Veleba, Eva Hoskova, Olena Oliyarnyk, Irena Markova, Lenka Thieme, Martin Hill, Terezie Pelikanova, Hana Kahleova
Publikováno v:
Nutrition & Metabolism, Vol 18, Iss 1, Pp 1-12 (2021)
Abstract Background Increased oxidative/dicarbonyl stress and chronic inflammation are considered key pathophysiological mediators in the progression of complications in obesity and type 2 diabetes (T2D). Lifestyle and diet composition have a major i
Externí odkaz:
https://doaj.org/article/b562009daea54f4caf1395c16c03bfd7
Publikováno v:
Journal of Diabetes Research, Vol 2022 (2022)
Introduction. Monounsaturated fatty acids (MUFA) are understood to have therapeutic and preventive effects on chronic complications associated with type 2 diabetes mellitus (T2DM); however, there are differences between individual MUFAs. Although the
Externí odkaz:
https://doaj.org/article/26e94ca82d9c4cec87d8e861d37f6ebe
Autor:
Irena Markova, Martina Hüttl, Olena Oliyarnyk, Tereza Kacerova, Martin Haluzik, Petr Kacer, Ondrej Seda, Hana Malinska
Publikováno v:
Nutrition & Metabolism, Vol 16, Iss 1, Pp 1-10 (2019)
Abstract Background and aims Dicarbonyl stress plays an important role in the pathogenesis of microvascular complications that precede the formation of advanced glycation end products, and contributes to the development of renal dysfunction. In renal
Externí odkaz:
https://doaj.org/article/4017ad84a2e04c1a9e915442955886fe
Autor:
Martina Hüttl, Irena Markova, Denisa Miklankova, Iveta Zapletalova, Martin Poruba, Zuzana Racova, Rostislav Vecera, Hana Malinska
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 45 (2021)
The combination of plant-derived compounds with anti-diabetic agents to manage hepatic steatosis closely associated with diabetes mellitus may be a new therapeutic approach. Silymarin, a complex of bioactive substances extracted from Silybum marianum
Externí odkaz:
https://doaj.org/article/8958765974644291a660f42016709d97
Autor:
Martin Poruba, Zuzana Matuskova, Martina Hüttl, Hana Malinska, Olena Oliyarnyk, Irena Markova, Sona Gurska, Ludmila Kazdova, Rostislav Vecera
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
P-glycoprotein (P-gp) is a membrane-bound transporter encoded by Mdr1a/Abcb1a and Mdr1b/Abcb1b genes in rodents involved in the efflux of cytotoxic chemicals and metabolites from cells. Modulation of its activity influences P-gp-mediated drug deliver
Externí odkaz:
https://doaj.org/article/113954a4a033452dbb722890110db9d1
Autor:
Hana Malinska, Martina Hüttl, Olena Oliyarnyk, Irena Markova, Martin Poruba, Zuzana Racova, Ludmila Kazdova, Rostislav Vecera
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220377 (2019)
BackgroundTroxerutin (TRX) has a beneficial effect on blood viscosity and platelet aggregation, and is currently used for the treatment of chronic varicosity. Recently, TRX can improve lipid abnormalities, glucose intolerance and oxidative stress in
Externí odkaz:
https://doaj.org/article/71daab0ab7594bec8c1d6c1d56e3c3c3
Autor:
Irena Markova, Denisa Miklankova, Martina Hüttl, Petr Kacer, Jelena Skibova, Jan Kucera, Radislav Sedlacek, Tereza Kacerova, Ludmila Kazdova, Hana Malinska
Publikováno v:
Journal of Diabetes Research, Vol 2019 (2019)
Introduction. The development of metabolic syndrome-associated renal dysfunction is exacerbated by a number of factors including dyslipidemia, ectopic deposition of lipids and their toxic metabolites, impairment of lipid metabolism, and insulin resis
Externí odkaz:
https://doaj.org/article/ab06606989474a81b1ad75c48b777697