The transcriptome landscape of the carcinogenic treatment response in the blind mole rat: insights into cancer resistance mechanisms

Autor: Robert Altwasser, Arnon Paz, Abraham Korol, Irena Manov, Aaron Avivi, Imad Shams

Publikováno v: BMC Genomics, Vol 20, Iss 1, Pp 1-15 (2019)

Abstract Background Spalax, the blind mole rat, developed an extraordinary cancer resistance during 40 million years of evolution in a subterranean, hypoxic, thus DNA damaging, habitat. In 50 years of Spalax research, no spontaneous cancer developmen

Externí odkaz: https://doaj.org/article/8916cad278a048b3ad817c476aeea0c6

Senescent Secretome of Blind Mole Rat Spalax Inhibits Malignant Behavior of Human Breast Cancer Cells Triggering Bystander Senescence and Targeting Inflammatory Response

Autor: Amani Odeh, Hossam Eddini, Lujain Shawasha, Anastasia Chaban, Aaron Avivi, Imad Shams, Irena Manov

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 5132

Subterranean blind mole rat, Spalax, has developed strategies to withstand cancer by maintaining genome stability and suppressing the inflammatory response. Spalax cells undergo senescence without the acquisition of senescence-associated secretory ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67880947e71b656477de6ea92e3b1bb0
https://doi.org/10.3390/ijms24065132

Telomeres and Longevity: A Cause or an Effect?

Autor: Susanne Holtze, Eva Leman, Lital Sharvit, Asael Roichman, Irena Manov, Haim Y. Cohen, Gil Atzmon, Huda Adwan Shekhidem, Imad Shams, Thomas B. Hildebrandt, Derek M. Huffman

Publikováno v: International Journal of Molecular Sciences
Volume 20
Issue 13
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3233 (2019)
International journal of molecular sciences, 20(13):3233

Telomere dynamics have been found to be better predictors of survival and mortality than chronological age. Telomeres, the caps that protect the end of linear chromosomes, are known to shorten with age, inducing cell senescence and aging. Furthermore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203fbafcafb67445e3f5aaf5936ff249

The transcriptome landscape of the carcinogenic treatment response in the blind mole rat: insights into cancer resistance mechanisms

Autor: Aaron Avivi, Irena Manov, Imad Shams, Abraham B. Korol, A. Paz, Robert Altwasser

Publikováno v: BMC Genomics, Vol 20, Iss 1, Pp 1-15 (2019)
BMC Genomics

Background Spalax, the blind mole rat, developed an extraordinary cancer resistance during 40 million years of evolution in a subterranean, hypoxic, thus DNA damaging, habitat. In 50 years of Spalax research, no spontaneous cancer development has bee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a03985c2473b098cafeb5afdeedafbb
https://doi.org/10.1186/s12864-018-5417-z

Iron-rich ferritin in the hypoxia-tolerant rodent Spalax ehrenbergi : A naturally-occurring biomarker confirms the internalization and pathways of intracellular macromolecules

Autor: Irena Manov, Talmon Arad, Imad Shams, Theodore C. Iancu

Publikováno v: Journal of Structural Biology. 187:254-265

The discovery of pits/caveolae in the plasmalemma advanced the study of macromolecule internalization. “Transcytosis” describes the transport of macromolecular cargo from one front of a polarized cell to the other within membrane-bounded carrier(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a295dbb7c754eb15a07ea80457f9bd5
https://doi.org/10.1016/j.jsb.2014.07.002