Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Irena Koutná"'
Publikováno v:
Journal of Immunology Research, Vol 2021 (2021)
Chimeric antigen receptor T-cells (CAR T-cells) represent a novel and promising approach in cancer immunotherapy. According to the World Health Organization (WHO), the number of oncological patients is steadily growing in developed countries despite
Externí odkaz:
https://doaj.org/article/78ce7186c41e485e82e24ea8674cb0fc
Autor:
Sebastiano Giallongo, Daniela Řeháková, Tommaso Biagini, Oriana Lo Re, Priyanka Raina, Gabriela Lochmanová, Zbyněk Zdráhal, Igor Resnick, Pille Pata, Illar Pata, Martin Mistrík, João Pedro de Magalhães, Tommaso Mazza, Irena Koutná, Manlio Vinciguerra
Publikováno v:
Stem Cells
DNA damage repair (DDR) is a safeguard for genome integrity maintenance. Increasing DDR efficiency could increase the yield of induced pluripotent stem cells (iPSC) upon reprogramming from somatic cells. The epigenetic mechanisms governing DDR during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cba99d815def05d578b86a2ab3ce289
https://doi.org/10.1093/stmcls/sxab004
https://doi.org/10.1093/stmcls/sxab004
Autor:
Tomáš Ventruba, Pavel Ventruba, Michal Ješeta, Jana Žáková, Eva Lousová, Igor Crha, Tereza Souralová, Irena Koutná, Aleš Hampl
Publikováno v:
Advances in Clinical and Experimental Medicine. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32caf8265074838421aedacf17f9674b
https://doi.org/10.17219/acem/158777
https://doi.org/10.17219/acem/158777
Autor:
Niccolò Liorni, Alessandro Napoli, Stefano Castellana, Sebastiano Giallongo, Daniela Řeháková, Oriana Lo Re, Irena Koutná, Tommaso Mazza, Manlio Vinciguerra
Human-induced pluripotent stem cells (iPSCs) can be derived from adult stem cells by forced expression of defined transcription factors. This paves the way for autologous iPSC-derived therapies, which, however, are not yet considered safe. Moreover,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0575617a5048d632c2cbf4482ac5f090
https://doi.org/10.1101/2022.09.30.510248
https://doi.org/10.1101/2022.09.30.510248
Autor:
Pavel Ventruba, Michal Ješeta, Jana Žáková, Tereza Souralová, Irena Koutná, Aleš Hampl, Eva Lousová, Igor Crha, Tomáš Ventruba
Human embryonic stem cells (hESCs) are used in cell therapy mainly in targeted therapy for not yet curable diseases such as diabetes mellitus, spinal cord injury or Parkinson's disease. The aim of this study is the derivation of clinical-grade hESCs,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::131d08c314b9c9b58e9f98efba5a2115
https://doi.org/10.21203/rs.3.rs-1956348/v1
https://doi.org/10.21203/rs.3.rs-1956348/v1
Autor:
Soňa Legartová, Paolo Fagherazzi, Pratik Goswami, Vaclav Brazda, Gabriela Lochmanová, Irena Koutná, Eva Bártová
Publikováno v:
Biochimie.
An essential factor of the DNA damage response is 53BP1, a multimeric protein that inhibits the resection-dependent double-strand break (DBS) repair. The p53 protein is a tumor suppressor known as a guardian of the genome. Although the interaction be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402cc7a2533d9ab6a49f7f88ef67db80
https://pubmed.ncbi.nlm.nih.gov/36167255
https://pubmed.ncbi.nlm.nih.gov/36167255
Autor:
Eva Lousová, Tereza Souralová, Michal Jeseta, Jana Žáková, Irena Koutná, Aleš Hampl, Pavel Ventruba
Publikováno v:
Česká gynekologie. 86:5-10
Objective The work deals with a clinical part of human embryonic stem cell (hESC) research. The aim of the project is the differentiation of somatic cell types, useful in drug development, regenerative medicine and cell therapy. The aim of this work
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf1127ba557f98fccfc2f4461dff5b4
https://doi.org/10.48095/cccg20215
https://doi.org/10.48095/cccg20215
Akademický článek
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Publikováno v:
Stem Cell Research, Vol 57, Iss, Pp 102574-(2021)
Human embryonic stem cells (hESCs) represent a virtually unlimited source of cells suitable for a variety of biomedical applications. However, a diminishing allogeneic background and undefined culture conditions are essential for developing robust an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5079071618b35dbc4c6bacd3454821b
https://pubmed.ncbi.nlm.nih.gov/34715503
https://pubmed.ncbi.nlm.nih.gov/34715503
Publikováno v:
Journal of Immunology Research
Journal of Immunology Research, Vol 2021 (2021)
Journal of Immunology Research, Vol 2021 (2021)
Chimeric antigen receptor T-cells (CAR T-cells) represent a novel and promising approach in cancer immunotherapy. According to the World Health Organization (WHO), the number of oncological patients is steadily growing in developed countries despite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95807a31ca3a157d9cfa7cf4bb2978a2
https://pubmed.ncbi.nlm.nih.gov/33855089
https://pubmed.ncbi.nlm.nih.gov/33855089