Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Irena Kadiu"'
Autor:
Manisha Padmakumar, Steven Biesmans, Jorge S. Valadas, Jan R. Detrez, Gaëlle Gillet, Priscillia Bresler, Marie-Laure Clénet, Irena Kadiu
Publikováno v:
Frontiers in Drug Discovery, Vol 3 (2023)
Neuroscience drug discovery has faced significant challenges due to restricted access to relevant human cell models and limited translatability of existing preclinical findings to human pathophysiology. Induced pluripotent stem cells (iPSCs) have eme
Externí odkaz:
https://doaj.org/article/4e10a82de23d46c7890710e9bc03d4d9
Autor:
Marie-Laure Clénet, James Keaney, Gaëlle Gillet, Jorge S. Valadas, Julie Langlois, Alvaro Cardenas, Julien Gasser, Irena Kadiu
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
NOD-Like Receptor Family Pyrin Domain Containing 3 (NLRP3) inflammasome modulation has emerged as a potential therapeutic approach targeting inflammation amplified by pyroptotic innate immune cell death. In diseases characterized by non-cell autonomo
Externí odkaz:
https://doaj.org/article/8ebc97ff867d42c99a352b940efac384
Autor:
Julien Gasser, Gaelle Gillet, Jorge S. Valadas, Laura Rouvière, Apoorva Kotian, Wenqiang Fan, James Keaney, Irena Kadiu
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Huntington’s disease (HD) is an inherited autosomal dominant neurodegenerative disease caused by CAG repeats in exon 1 of the HTT gene. A hallmark of HD along with other psychiatric and neurodegenerative diseases is alteration in the neuronal circu
Externí odkaz:
https://doaj.org/article/36f81fae85e74d06aa8c531767ce20bb
Autor:
Mohammad Mahmud, Charles Wade, Sarah Jawad, Zaeem Hadi, Christian Otoul, Rafal M. Kaminski, Pierandrea Muglia, Irena Kadiu, Eugenii Rabiner, Paul Maguire, David R. Owen, Michael R. Johnson
Publikováno v:
Frontiers in Neuroimaging, Vol 2 (2023)
ObjectiveTranslocator protein (TSPO) targeting positron emission tomography (PET) imaging radioligands have potential utility in epilepsy to assess the efficacy of novel therapeutics for targeting neuroinflammation. However, previous studies in healt
Externí odkaz:
https://doaj.org/article/8ac866fbfb8544ee9f7ba34f2fbbf4c0
Autor:
Prashant K. Srivastava, Jonathan van Eyll, Patrice Godard, Manuela Mazzuferi, Andree Delahaye-Duriez, Juliette Van Steenwinckel, Pierre Gressens, Benedicte Danis, Catherine Vandenplas, Patrik Foerch, Karine Leclercq, Georges Mairet-Coello, Alvaro Cardenas, Frederic Vanclef, Liisi Laaniste, Isabelle Niespodziany, James Keaney, Julien Gasser, Gaelle Gillet, Kirill Shkura, Seon-Ah Chong, Jacques Behmoaras, Irena Kadiu, Enrico Petretto, Rafal M. Kaminski, Michael R. Johnson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The identification of new drug targets is highly challenging, particularly for diseases of the brain. This study describes a general computational gene regulatory framework called CRAFT for drug target discovery, and the authors use CRAFT to identify
Externí odkaz:
https://doaj.org/article/c0cffc3635504945bbe2f39f8175da2f
Autor:
Tong Wang, Nan Gong, Jianuo Liu, Irena Kadiu, Stephanie D Kraft-Terry, R Lee Mosley, David J Volsky, Pawel Ciborowski, Howard E Gendelman
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2507 (2008)
HIV-1-infected and immune competent brain mononuclear phagocytes (MP; macrophages and microglia) secrete cellular and viral toxins that affect neuronal damage during advanced disease. In contrast, astrocytes can affect disease by modulating the nervo
Externí odkaz:
https://doaj.org/article/a729e563ab1c4e3fa6d69264b66153e1
Autor:
Ute Häussler, João Neres, Catherine Vandenplas, Caroline Eykens, Irena Kadiu, Carolin Schramm, Renaud Fleurance, Phil Stanley, Patrice Godard, Laurane de Mot, Jonathan van Eyll, Klaus-Peter Knobeloch, Carola A. Haas, Stefanie Dedeurwaerdere
Structural epilepsies display complex immune activation signatures; however, it is unclear which neuroinflammatory pathways drive disease pathobiology. Transcriptome studies of brain resections from mesial temporal lobe epilepsy (mTLE) patients revea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4335cefb20212e8fc9401815cd3fa9c1
https://doi.org/10.21203/rs.3.rs-2625841/v1
https://doi.org/10.21203/rs.3.rs-2625841/v1
Autor:
Mohammad Mahmud, Charles Wade, Sarah Jawad, Zaeem Hadi, Christian Otoul, Rafal M. Kaminski, Pierandrea Muglia, Irena Kadiu, Eugenii Rabiner, Paul Maguire, David R. Owen, Michael R. Johnson
ObjectiveTranslocator protein (TSPO) targeting positron emission tomography (PET) imaging radioligands have potential utility in epilepsy to assess the efficacy of novel therapeutics for targeting neuroinflammation. However, previous studies in healt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39c96e1791dc3f6c10705bda7abe5f5
http://hdl.handle.net/10044/1/103496
http://hdl.handle.net/10044/1/103496
Autor:
Mohammad Mahmud, Charles Wade, Sarah Jawad, Zaeem Hadi, Christian Otoul, Rafal M. Kaminski, Pierandrea Muglia, Irena Kadiu, Eugenii A. Rabiner, Paul Maguire, David R. Owen, Michael R. Johnson
Publikováno v:
SSRN Electronic Journal.
Autor:
Steven A. McCarroll, Brian J. Joseph, Inma Cobos, Laura Bortolin, Irena Kadiu, Sulagna Ghosh, Alexander Couto, Aaron Burberry, Daniel Meyer, Kevin Eggan, Olli Pietilainen, Melissa Goldman, Francesco Limone, Beth Stevens, Martine Therrien, Daniel A. Mordes
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder characterised by a progressive loss of motor function. The eponymous spinal sclerosis observed at autopsy is the result of the degeneration of extratelencephalic neurons, Betz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8831769520c89a3efdd9b877e0f309d6
https://doi.org/10.1101/2021.07.12.452054
https://doi.org/10.1101/2021.07.12.452054