Procalcitonin guidance in patients with lower respiratory tract infections: a systematic review and meta-analysis

Autor: Bernie Rice, Irena Iankova, Philipp Schuetz, Louise Zimmer, Sophie A Schonfeld, Dana Wilkins, Samuel A. Bozzette, Christopher R DeBrase, Alexander Krause, Philippe Thompson-Leduc, Noam Y. Kirson, Juliane Hey

Publikováno v: Clinical Chemistry and Laboratory Medicine (CCLM). 56:1200-1209

Although effective for bacterial lower respiratory tract infections (LRTIs), antibiotic treatment is often incorrectly prescribed for non-bacterial LRTIs. Procalcitonin has emerged as a promising biomarker to diagnose bacterial infections and guide a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd63a2e2de4b861a00caede507654d58
https://doi.org/10.1515/cclm-2018-0126

Efficacy and Safety of Procalcitonin Guidance in Patients With Suspected or Confirmed Sepsis: A Systematic Review and Meta-Analysis

Autor: Alexander Krause, Irena Iankova, Samuel A. Bozzette, Noam Y. Kirson, Sophie A Schonfeld, Juliane Hey, Philippe Thompson-Leduc, Bernie Rice, Philipp Schuetz, Christopher R DeBrase

Publikováno v: Critical care medicine. 46(5)

Sepsis is a leading cause of mortality in noncoronary ICUs. Although immediate start of antibiotics reduces sepsis-related mortality, antibiotics are often administered for too long, leading to suboptimal treatment and, importantly, contributes to an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b297b0f29214984ff76d06123e5cf891
https://pubmed.ncbi.nlm.nih.gov/30113378

Nuclear receptors in the cross-talk of drug metabolism and inflammation

Autor: Irena Iankova, Patrick Maurel, Sabine Gerbal-Chaloin, Martine Daujat-Chavanieu

Publikováno v: Drug metabolism reviews. 45(1)

Inflammation and infection have long been known to affect the activity and expression of enzymes involved in hepatic and extrahepatic drug clearance. Significant advances have been made to elucidate the molecular mechanisms underlying the complex cro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05627bfc83ba396f5ebb2b89706006d
https://pubmed.ncbi.nlm.nih.gov/23330545

The CDK4-pRB-E2F1 pathway controls insulin secretion

Autor: Stéphane Dalle, Lluis Fajas, Safia Costes, Emilie Blanchet, Said Assou, Jean-Sébastien Annicotte, Irena Iankova, Claude Sardet, Carine Chavey, Jacques Teyssier

Publikováno v: Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2009, 11 (8), pp.1017-1023. ⟨10.1038/ncb1915⟩
Nature Cell Biology, Nature Publishing Group, 2009, 11 (8), pp.1017-23. 〈10.1038/ncb1915〉
Nature Cell Biology, 2009, 11 (8), pp.1017-23. ⟨10.1038/ncb1915⟩
Nature Cell Biology, Nature Publishing Group, 2009, 11 (8), pp.1017-23. ⟨10.1038/ncb1915⟩

International audience; CDK4-pRB-E2F1 cell-cycle regulators are robustly expressed in non-proliferating beta cells, suggesting that besides the control of beta-cell number the CDK4-pRB-E2F1 pathway has a role in beta-cell function. We show here that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ff8a1404638ea3f738e39e2364f733d
https://pubmed.ncbi.nlm.nih.gov/19597485

Functional remodeling of gap junction-mediated electrical communication between adrenal chromaffin cells in stressed rats

Autor: Luis A Olivos Ore, Pierre Fontanaud, Laurent Yon, Nathalie Coutry, Erwan Thouënnon, Nathalie C. Guérineau, Françoise Macari, Sébastien Arthaud, Youssef Anouar, Claude Colomer, Irena Iankova, Marie-Noëlle Mathieu

Publikováno v: Journal of Neuroscience
Journal of Neuroscience, Society for Neuroscience, 2008, 28 (26), pp.6616-26. ⟨10.1523/JNEUROSCI.5597-07.2008⟩

International audience; An increase in circulating catecholamine levels represents one of the mechanisms whereby organisms cope with stress. In the periphery, catecholamines mainly originate from the sympathoadrenal system. As we reported, in additio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c00bf8e48b5a50a06fb72adee2415a3
https://www.hal.inserm.fr/inserm-00281272/document