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pro vyhledávání: '"Irena Daniewski"'
Autor:
Hong Yang, Irena Daniewski, Dorota Miklowski, Brian Higgins, Giacomo Pizzolato, Fred Konzelmann, Christine Lukacs, Peter Michael Wovkulich, Rossman Pamela Loreen, Kenneth Kolinsky, Xuefeng Yin, Wei Chung-Chen, Grace Ju, Qingjie Ding, Kshitij Chhabilbhai Thakkar, Amy Swain, Jin-Jun Liu
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(20)
A novel series of pyrazolobenzodiazepines 3 has been identified as potent inhibitors of cyclin-dependent kinase 2 (CDK2). Their synthesis and structure-activity relationships (SAR) are described. Representative compounds from this class reversibly in