Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Irena Bočkaj"'
Autor:
Irena Bočkaj, Anna Moreno Garcia, Pablo de Miguel Herraiz, Sonay Keskin, Vanessa Zancanella, Şeyda Acar Broekmans, Astrid Vallès, Ying Poi Liu, Melvin Evers, Morgane Wartel
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 3, Pp 102307- (2024)
Given that numerous genetic disorders, driven by diverse pathogenic mechanisms, may be amenable to recombinant adeno-associated virus (rAAV)-delivered gene therapies, the sustained innovation of rAAV-based therapeutic modalities is crucial. The progr
Externí odkaz:
https://doaj.org/article/1a25866587ba456692cfabb12dd9d7ec
Autor:
Stéphane J. Baudouin, April R. Giles, Nick Pearson, Severine Deforges, Chenxia He, Céline Boileau, Nicolas Partouche, Andreas Borta, Justine Gautron, Morgane Wartel, Irena Bočkaj, Didier Scavarda, Fabrice Bartolomei, Guillaume Penchet, Jérôme Aupy, Jennifer Sims, Jared Smith, Andrew Mercer, Olivier Danos, Christophe Mulle, Valérie Crépel, Richard Porter
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101342- (2024)
Mesial temporal lobe epilepsy (mTLE) is the most prevalent type of epilepsy in adults. First and subsequent generations of anti-epileptic therapy regimens fail to decrease seizures in a large number of patients suffering from mTLE, leaving surgical a
Externí odkaz:
https://doaj.org/article/b7eefb3836e346488c8327be3214fc97
Autor:
Irena Bočkaj, Tosca E. I. Martini, Eduardo S. de Camargo Magalhães, Petra L. Bakker, Tiny G. J. Meeuwsen-de Boer, Inna Armandari, Saskia L. Meuleman, Marin T. Mondria, Colin Stok, Yannick P. Kok, Bjorn Bakker, René Wardenaar, Jonas Seiler, Mathilde J. C. Broekhuis, Hilda van den Bos, Diana C. J. Spierings, Femke C. A. Ringnalda, Hans Clevers, Ulrich Schüller, Marcel A. T. M. van Vugt, Floris Foijer, Sophia W. M. Bruggeman
Publikováno v:
PLoS Genetics, Vol 17, Iss 11 (2021)
While comprehensive molecular profiling of histone H3.3 mutant pediatric high-grade glioma has revealed extensive dysregulation of the chromatin landscape, the exact mechanisms driving tumor formation remain poorly understood. Since H3.3 mutant gliom
Externí odkaz:
https://doaj.org/article/f0f9f42a292e496a8dbe120dc4b20697
Autor:
Irena Bočkaj, Tosca E. I. Martini, Marlinde J. Smit, Inna Armandari, Bjorn Bakker, René Wardenaar, Tiny G. J. Meeuwsen-de Boer, Petra L. Bakker, Diana C. J. Spierings, Eelco W. Hoving, Victor Guryev, Floris Foijer, Sophia W. M. Bruggeman
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 17; Pages: 9852
International Journal of Molecular Sciences, 23(17):9852. MDPI AG
International Journal of Molecular Sciences, 23(17):9852. MDPI AG
Medulloblastoma is a pediatric brain malignancy that consists of four transcriptional subgroups. Structural and numerical aneuploidy are common in all subgroups, although they are particularly profound in Group 3 and Group 4 medulloblastoma and in a
Autor:
Marlinde J. Smit, Tosca E. I. Martini, Inna Armandari, Irena Bočkaj, Walderik W. Zomerman, Eduardo S. de Camargo Magalhães, Zillah Siragna, Tiny G. J. Meeuwsen, Frank J. G. Scherpen, Mirthe H. Schoots, Martha Ritsema, Wilfred F. A. den Dunnen, Eelco W. Hoving, Judith T. M. L. Paridaen, Gerald de Haan, Victor Guryev, Sophia W. M. Bruggeman
Publikováno v:
Journal of Cell Science, 135(11):jeb258608. COMPANY OF BIOLOGISTS LTD
Sonic hedgehog (SHH) medulloblastoma originates from the cerebellar granule neuron progenitor (CGNP) lineage, which depends on Hedgehog signaling for its perinatal expansion. Whereas SHH tumors exhibit overall deregulation of this pathway, they also
Autor:
Mark C. deGooijer, Arnout van denTop, Irena Bockaj, Jos H. Beijnen, Thomas Würdinger, Olaf vanTellingen
Publikováno v:
FEBS Open Bio, Vol 7, Iss 4, Pp 439-455 (2017)
Tight regulation of the eukaryotic cell cycle is paramount to ensure genomic integrity throughout life. Cell cycle checkpoints are present in each phase of the cell cycle and prevent cell cycle progression when genomic integrity is compromised. The G
Externí odkaz:
https://doaj.org/article/2b011d380df942bbb2f081efe8bc3fe0