Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Irena Berezowska"'
Autor:
Bogdan A Danalache, Jolanta Gutkowska, Magdalena J Slusarz, Irena Berezowska, Marek Jankowski
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13643 (2010)
Oxytocin (OT), synthesized in the heart, has the ability to heal injured hearts and to promote cardiomyogenesis from stem cells. Recently, we reported that the OT-GKR molecule, a processing intermediate of OT, potently increased the spontaneous forma
Externí odkaz:
https://doaj.org/article/22975b2f8b2640d9904d1bd1ea57ed63
Publikováno v:
Journal of Medicinal Chemistry. 52:6941-6945
The novel phenylalanine analogues 4'-[N-((4'-phenyl)phenethyl)carboxamido]phenylalanine (Bcp) and 2',6'-dimethyl-4'-[N-((4'-phenyl)phenethyl)carboxamido]phenylalanine (Dbcp) were substituted for Tyr(1) in the delta opioid antagonist TIPP (H-Tyr-Tic-P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ddcf2983c4d9cdc1a14404c3501a182
https://doi.org/10.1021/jm9004913
https://doi.org/10.1021/jm9004913
Publikováno v:
Acta Biochimica Polonica. 53:73-76
The dermorphin-derived cyclic tetrapeptide analogues H-Tyr-c[D-Cys-Phe-Cys]NH(2) and H-Tyr-c[D-Cys-Phe-D-Cys]NH(2) are opioid agonists at the mu and delta receptor. To enhance the metabolic stability of these peptides, we replaced the disulfide bridg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::327ec7deb92a62e64495f2786b042f1c
https://doi.org/10.18388/abp.2006_3363
https://doi.org/10.18388/abp.2006_3363
Publikováno v:
Journal of Peptide Research. 65:556-563
The dermorphin-derived tetrapeptide H-Dmt-d-Arg-Phe-Lys-NH(2) (Dmt = 2',6'-dimethyltyrosine) ([Dmt(1)]DALDA) is a highly potent and selective mu-opioid agonist capable of crossing the blood-brain barrier and producing a potent, centrally mediated ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a17558c30f12756f8192319892b394a3
https://doi.org/10.1111/j.1399-3011.2005.00252.x
https://doi.org/10.1111/j.1399-3011.2005.00252.x
Publikováno v:
Acta Biochimica Polonica. 51:107-113
Dansylated analogues of the potent and selective micro opioid peptide agonist [Dmt(1)]DALDA (H-Dmt-D-Arg-Phe-Lys-NH(2); Dmt = 2',6'-dimethyltyrosine) were prepared either by substitution of N(beta)-dansyl-alpha,beta-diaminopropionic acid or N(epsilon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6a449f7e5a255c270dc4286050bcde
https://doi.org/10.18388/abp.2004_3601
https://doi.org/10.18388/abp.2004_3601
Characterization of the Binding of [3H][Dmt1]H-Dmt-d-Arg-Phe-Lys-NH2, a Highly Potent Opioid Peptide
Autor:
Peter W. Schiller, Adam J. Janvey, Gavril W. Pasternak, Claire L. Neilan, Thi M.-D. Nguyen, Irena Berezowska, Elizabeth Bolan
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 306:430-436
The dermorphin-derived peptide [Dmt 1 ]DALDA (H-Dmt-d-Arg-Phe-Lys-NH 2 ; Dmt, 2′,6′-dimethyltyrosine) labels μ-opioid receptors with high affinity and selectivity in receptor binding assays. In previous studies, [Dmt 1 ]DALDA displayed a mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9463ae23f202f52f00cbe2254b44413
https://doi.org/10.1124/jpet.103.049742
https://doi.org/10.1124/jpet.103.049742
Autor:
Megumi Shimoyama, Peter W. Schiller, Yi Soong, Dunli Wu, Irena Berezowska, Hazel H. Szeto, Guo-Min Zhao
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 302:188-196
Recent studies suggest that delta-opioid receptors play a role in the development of opioid tolerance and led us to hypothesize that highly selective mu-opioid agonists may produce less tolerance. H-2',6'-dimethyltyrosine-D-Arg-Phe-Lys-NH(2) ([Dmt(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90f340260851097d2048e8672b1f455
https://doi.org/10.1124/jpet.302.1.188
https://doi.org/10.1124/jpet.302.1.188
Autor:
Thi M.-D. Nguyen, Carole Lemieux, Peter W. Schiller, Irena Berezowska, Grazyna Weltrowska, Nga N. Chung, Yixin Lu
Publikováno v:
Journal of Medicinal Chemistry. 44:3048-3053
Recent studies showed that dermorphin and enkephalin analogues containing two methyl groups at the 2',6'-positions of the Tyr(1) aromatic ring and lacking an N-terminal amino group were moderately potent delta and mu opioid antagonists. These results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9039d03999e58a9c6c5c231673cb1649
https://doi.org/10.1021/jm0101186
https://doi.org/10.1021/jm0101186
Autor:
Carole Lemieux, Nga N. Chung, Thi M.-D. Nguyen, Irena Berezowska, Peter W. Schiller, Grazyna Weltrowska, Sébastien Dupuis
Publikováno v:
European Journal of Medicinal Chemistry. 35:895-901
The tetrapeptide DALDA (H-Tyr-D-Arg-Phe-Lys-NH2) is a polar and selective mu agonist showing poor penetration of the placental and blood-brain barriers. In an effort to enhance the potency of DALDA, analogues containing 2',6'-dimethyltyrosine (Dmt),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146413663f9f3c3851aaac96881ebd15
https://doi.org/10.1016/s0223-5234(00)01171-5
https://doi.org/10.1016/s0223-5234(00)01171-5
Autor:
Seiji Iwama, Carole Lemieux, Irena Berezowska, Josephine Liu, Nga N. Chung, Ralf Schmidt, Thi M.-D. Nguyen, Amos B. Smith, Margaret L. Falcone-Hindley, Peter W. Schiller, Wenqing Yao, Ralph Hirschmann
Publikováno v:
Journal of Medicinal Chemistry. 43:551-559
Recently we reported using minilibraries to replace Lys(9) [somatostatin (SRIF) numbering] of the potent somatostatin agonist L-363,301 (c[-Pro-Phe-D-Trp-Lys-Thr-Phe-]) to generate the potent neurokinin receptor (NK-1) antagonist c[-Pro-Phe-D-Trp-p-F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1e0070eb1f052150bba2481bd774e3
https://doi.org/10.1021/jm990461z
https://doi.org/10.1021/jm990461z