Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Irena B, King"'
Autor:
Amanda M. Fretts, Paul N. Jensen, Colleen M. Sitlani, Andy Hoofnagle, Benjamin Lidgard, Jason G. Umans, David S. Siscovick, Irena B. King, Barbara V. Howard, Shelley A. Cole, Rozenn N. Lemaitre
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 13 (2024)
Background A growing body of research indicates that associations of ceramides and sphingomyelins with mortality depend on the chain length of the fatty acid acylated to the backbone sphingoid base. We examined associations of 8 ceramide and sphingom
Externí odkaz:
https://doaj.org/article/ae8a9bcf773c4ab598ad1715e39a325f
Autor:
Paul N. Jensen, Amanda M. Fretts, Andrew N. Hoofnagle, Barbara McKnight, Barbara V. Howard, Jason G. Umans, Colleen M. Sitlani, David S. Siscovick, Irena B. King, Nona Sotoodehnia, Rozenn N. Lemaitre
Publikováno v:
Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-10 (2022)
Abstract Background Plasma ceramides and sphingomyelins have been independently linked to diabetes risk, glucose and insulin levels, and the risk of several cardiovascular (CVD) outcomes. However, whether individual ceramide and sphingomyelin species
Externí odkaz:
https://doaj.org/article/54129391a2444a28a02c387c62d4d169
Autor:
Rozenn N. Lemaitre, Paul N. Jensen, Maxwell Zeigler, Amanda M. Fretts, Jason G. Umans, Barbara V. Howard, Colleen M. Sitlani, Barbara McKnight, Sina A. Gharib, Irena B. King, David S. Siscovick, Bruce M. Psaty, Nona Sotoodehnia, Rheem A. Totah
Publikováno v:
EBioMedicine, Vol 83, Iss , Pp 104189- (2022)
Summary: Background: Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid that may impact atherosclerosis, and animal experimental studies suggest EETs protect cardiac function. Plasma EETs are mostly esterified to phospholipids and p
Externí odkaz:
https://doaj.org/article/2df301d177d4451f903cbf396c53c760
Autor:
Paul N. Jensen, Amanda M. Fretts, Chaoyu Yu, Andrew N. Hoofnagle, Jason G. Umans, Barbara V. Howard, Colleen M. Sitlani, David S. Siscovick, Irena B. King, Nona Sotoodehnia, Barbara McKnight, Rozenn N. Lemaitre
Publikováno v:
EBioMedicine, Vol 41, Iss , Pp 44-49 (2019)
Background: Animal studies suggest sphingolipids as an early marker of impaired glucose metabolism; however, research in humans is limited. We evaluated whether individual sphingolipid species were associated with fasting plasma glucose and incident
Externí odkaz:
https://doaj.org/article/9efd163dd2094b4b8ab5335ed7f29dd4
Autor:
Rozenn N. Lemaitre, Paul N Jensen, Maxwell Zeigler, Julie Denham, Amanda M. Fretts, Jason G. Umans, Barbara V. Howard, Colleen M. Sitlani, Barbara McKnight, Sina A. Gharib, Irena B. King, David S. Siscovick, Bruce M Psaty, Nona Sotoodehnia, Rheem A. Totah
Publikováno v:
EBioMedicine, Vol 66, Iss , Pp 103279- (2021)
Background: Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid with multiple biological functions. Rodent experiments suggest EETs play a role in insulin sensitivity and diabetes, but evidence in humans is limited. To address this k
Externí odkaz:
https://doaj.org/article/40e9401f43b9490eb1ea7c2ed4507c38
Autor:
Amanda M. Fretts, Paul N. Jensen, Andrew N. Hoofnagle, Barbara McKnight, Barbara V. Howard, Jason Umans, Colleen M. Sitlani, David S. Siscovick, Irena B. King, Luc Djousse, Nona Sotoodehnia, Rozenn N. Lemaitre
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100119- (2021)
Recent studies suggest that the type of saturated fatty acid bound to sphingolipids influences the biological activity of those sphingolipids. However, it is unknown whether associations of sphingolipids with diabetes may differ by the identity of bo
Externí odkaz:
https://doaj.org/article/0917e90c47af468fb367acaaa4679314
Autor:
Paul N. Jensen, Amanda M. Fretts, Andrew N. Hoofnagle, Colleen M. Sitlani, Barbara McKnight, Irena B. King, David S. Siscovick, Bruce M. Psaty, Susan R. Heckbert, Dariush Mozaffarian, Nona Sotoodehnia, Rozenn N. Lemaitre
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 4 (2020)
Background Ceramides exhibit multiple biological activities that may influence the pathophysiological characteristics of atrial fibrillation (AF). Whether the length of the saturated fatty acid carried by the ceramide or their sphingomyelin precursor
Externí odkaz:
https://doaj.org/article/5c2477103db34a5db919e16aaa13c4c6
Autor:
Yujin Lee, Heidi T. M. Lai, Marcia C. de Oliveira Otto, Rozenn N. Lemaitre, Barbara McKnight, Irena B. King, Xiaoling Song, Gordon S. Huggins, Amanda R. Vest, David S. Siscovick, Dariush Mozaffarian
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 4 (2020)
Background De novo lipogenesis (DNL) is an endogenous pathway that converts excess dietary starch, sugar, protein, and alcohol into specific fatty acids (FAs). Although elevated DNL is linked to several metabolic abnormalities, little is known about
Externí odkaz:
https://doaj.org/article/7e4a0e4b6ead41d4ab4f5f3d1fb33292
Autor:
Heidi T.M. Lai, Marcia C. de Oliveira Otto, Yujin Lee, Jason H.Y. Wu, Xiaoling Song, Irena B. King, Bruce M. Psaty, Rozenn N. Lemaitre, Barbara McKnight, David S. Siscovick, Dariush Mozaffarian
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 22 (2019)
Background Synthesized fatty acids (FAs) from de novo lipogenesis may affect cardiometabolic health, but longitudinal associations between serially measured de novo lipogenesis–related fatty acid biomarkers and mortality or cardiovascular disease (
Externí odkaz:
https://doaj.org/article/c432f100a04a4769a8dacfabbb8106f6
Autor:
Yao Hu, Toshiko Tanaka, Jingwen Zhu, Weihua Guan, Jason H.Y. Wu, Bruce M. Psaty, Barbara McKnight, Irena B. King, Qi Sun, Melissa Richard, Ani Manichaikul, Alexis C. Frazier-Wood, Edmond K. Kabagambe, Paul N. Hopkins, Jose M. Ordovas, Luigi Ferrucci, Stefania Bandinelli, Donna K. Arnett, Yii-Der I. Chen, Shuang Liang, David S. Siscovick, Michael Y. Tsai, Stephen S. Rich, Myriam Fornage, Frank B. Hu, Eric B. Rimm, Majken K. Jensen, Rozenn N. Lemaitre, Dariush Mozaffarian, Lyn M. Steffen, Andrew P. Morris, Huaixing Li, Xu Lin
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 5, Pp 974-981 (2017)
MUFAs are unsaturated FAs with one double bond and are derived from endogenous synthesis and dietary intake. Accumulating evidence has suggested that plasma and erythrocyte MUFA levels are associated with cardiometabolic disorders, including CVD, T2D
Externí odkaz:
https://doaj.org/article/44c9aaa4c707484ead48ec7020a3aff9