Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Iram F Khan"'
Autor:
Swati Singh, Cole M. Pugliano, Yuchi Honaker, Aidan Laird, M. Quinn DeGottardi, Ezra Lopez, Stefan Lachkar, Claire Stoffers, Karen Sommer, Iram F. Khan, David J. Rawlings
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 1, Pp 101183- (2024)
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a monogenic disorder caused by mutations in the FOXP3 gene, required for generation of regulatory T (Treg) cells. Loss of Treg cells leads to immune dysregulation char
Externí odkaz:
https://doaj.org/article/70f1555ee4fe46088c5297fc8c0bb2a2
Autor:
Rene Yu-Hong Cheng, King L. Hung, Tingting Zhang, Claire M. Stoffers, Andee R. Ott, Emmaline R. Suchland, Nathan D. Camp, Iram F. Khan, Swati Singh, Ying-Jen Yang, David J. Rawlings, Richard G. James
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Plasma B cells (PC) are a potential source for protein replacement as they could be engineered to secrete protein other than antibody. Here the authors engineer B cells to express exogenous proteins and demonstrate that these cells can persist long t
Externí odkaz:
https://doaj.org/article/a7a059db17ba4c239eb066542f930a81
Autor:
Brenda J. Seymour, Swati Singh, Hannah M. Certo, Karen Sommer, Blythe D. Sather, Socheath Khim, Courtnee Clough, Malika Hale, Joseph Pangallo, Byoung Y. Ryu, Iram F. Khan, Jennifer E. Adair, David J. Rawlings
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 635-651 (2021)
X-linked agammaglobulinemia (XLA) is an immune disorder caused by mutations in Bruton’s tyrosine kinase (BTK). BTK is expressed in B and myeloid cells, and its deficiency results in a lack of mature B cells and protective antibodies. We previously
Externí odkaz:
https://doaj.org/article/4469c8d686fc425a84ca48e687ffdce5
Autor:
Rene Yu-Hong Cheng, King L. Hung, Tingting Zhang, Claire M. Stoffers, Andee R. Ott, Emmaline R. Suchland, Nathan D. Camp, Iram F. Khan, Swati Singh, Ying-Jen Yang, David J. Rawlings, Richard G. James
Publikováno v:
Nature communications. 13(1)
Due to their unique longevity and capacity to secrete high levels of protein, plasma B cells have the potential to be used as a cell therapy for protein replacement. Here, we show that ex vivo engineered human plasma cells exhibit single-cell RNA pro
Autor:
Aaron Seese, Erin M. Scherer, Kristen W. Cohen, Andrew T. McGuire, Joseph J. Carter, Sarah Ameny, M. Juliana McElrath, Abigail Wall, Denise A. Galloway, David J. Rawlings, Rachael E. Whaley, Tanvi Arkatkar, Iram F. Khan
Publikováno v:
Journal of Immunological Methods
The isolation of human monoclonal antibodies (mAbs) arising from natural infection with human pathogens has proven to be a powerful technology, facilitating the understanding of the host response to infection at a molecular level. mAbs can reveal sit
Autor:
Christina Lopez, David J. Rawlings, Andrew M. Scharenberg, David Hagin, Troy R. Torgerson, Tori Tappen, Malika Hale, Soo Jung Yang, Honaker Yuchi Chiang, Karen Sommer, Iram F. Khan, Logan Fisher, Yumei Song, Nicholas Hubbard, Yufei Xiang, Jane H. Buckner, Elizabeth M. Dam
Publikováno v:
Science Translational Medicine. 12
Thymic regulatory T cells (tTregs) are potent inhibitors of autoreactive immune responses, and loss of tTreg function results in fatal autoimmune disease. Defects in tTreg number or function are also implicated in multiple autoimmune diseases, leadin
Autor:
Carol H. Miao, Iana Meitlis, Swati Singh, Iram F. Khan, King L. Hung, Chun-Yu Chen, Shaun W. Jackson, David J. Rawlings, Malika Hale, Richard G. James
Publikováno v:
Molecular Therapy
The ability to engineer primary human B cells to differentiate into long-lived plasma cells and secrete a de novo protein may allow the creation of novel plasma cell therapies for protein deficiency diseases and other clinical applications. We initia
Autor:
Zachary K. Norgaard, Swati Singh, Socheath Khim, Jennifer E. Adair, Brenda Seymour, David J. Rawlings, Matthew M. Wielgosz, Denny Liggitt, Karen Sommer, Arthur W. Nienhuis, Iram F. Khan, Hans-Peter Kiem
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 1-16 (2017)
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 1-16 (2017)
Wiskott-Aldrich syndrome (WAS) is a life-threatening immunodeficiency caused by mutations within the WAS gene. Viral gene therapy to restore WAS protein (WASp) expression in hematopoietic cells of patients with WAS has the potential to improve outcom
Autor:
Simon C. Shin, Dao Pan, David J. Rawlings, Andy F J Chiang, Xuefeng Wang, Iram F. Khan, Carol H. Miao
Publikováno v:
Molecular Therapy. 23:617-626
Intraosseous (IO) infusion of lentiviral vectors (LVs) for in situ gene transfer into bone marrow may avoid specific challenges posed by ex vivo gene delivery, including, in particular, the requirement of preconditioning. We utilized IO delivery of L