Výsledky vyhledávání - "Iraj Ghadiminejad"

Neonatal carnitine palmitoyltransferase-2 deficiency: a case presenting with myopathy

Autor: Iraj Ghadiminejad, Sharad Mistry, David Saggerson, Marian Squier, Michael Orford, Peter Hope, John M. Land

Publikováno v: Neuromuscular disorders : NMD. 5(2)

Mitochondria were isolated from liver, heart and skeletal muscle of a 34-day-old female infant who died from a myopathic illness. Muscle biopsy showed lipid accumulation and no obvious pathology in any other organ. Enzymatic analysis of skeletal musc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40089ca6a5d671ea501ba7a02a6402ec
https://pubmed.ncbi.nlm.nih.gov/7767092

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Physiological state and the sensitivity of liver mitochondrial outer membrane carnitine palmitoyltransferase to malonyl-CoA. Correlations with assay temperature, salt concentration and membrane lipid composition

Autor: Iraj Ghadiminejad, David Saggerson

Publikováno v: The International journal of biochemistry. 24(7)

1. Liver mitochondrial outer membranes were pre-exposed to media of low (20 mM phosphate) or high salt concentration (20 mM phosphate + 0.3 M KCl) before assay of carnitine palmitoyltransferase (CPT) at 25 degrees C. 2. With membranes from fed rats,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afab91f1df8a00d4fc3e47fcb00281f5
https://pubmed.ncbi.nlm.nih.gov/1397505

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Use of mitochondrial inner membrane proteins and phospholipids to facilitate disengagement of the catalytic and malonyl-CoA binding components of carnitine palmitoyltransferase from liver mitochondrial outer membranes

Autor: David Saggerson, Iraj Ghadiminejad

Publikováno v: The International journal of biochemistry. 24(4)

1. 1. It was shown by Ghadiminejad and Saggerson (1991) that the anionic detergent cholate caused disengagement of the malonyl-CoA binding entity from the catalytic entity of outer membrane carnitine palmitoyltransferase (Cpt 1 ). 2. 2. This disengag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4722fa47cfe190d8404f11c2341f4b85
https://pubmed.ncbi.nlm.nih.gov/1516729

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Regulation of mitochondrial carnitine palmitoyl transferases from liver and extrahepatic tissues

Autor: David Saggerson, M. Moneeb Awan, Iraj Ghadiminejad

Publikováno v: Advances in enzyme regulation. 32

Developments in our understanding of the complex CPT enzyme system over the past ten years have been reviewed. Liver CPT1, which is probably distinct from that in several extrahepatic tissues, is subject to up- or down-regulation of its activity and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51f4c9b0e90c4340a8fc20363f64c565
https://pubmed.ncbi.nlm.nih.gov/1496923

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A proportion of rat liver mitochondrial carnitine palmitoyltransferase can be made activatable by malonyl-CoA

Autor: David Saggerson, Iraj Ghadiminejad

Publikováno v: Biochimica et biophysica acta. 1085(3)

Treatment of rat liver mitochondrial membranes with cholate yields a soluble extract containing carnitine palmitolytransferase (CPT) activity that is insensitive to malonyl-CoA. As found previously ( I. Ghadiminejad and D. Saggerson (1990) FEBS Lett.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a2d662d160cdcee755c1cfb6e5d177d
https://pubmed.ncbi.nlm.nih.gov/1911872

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A study of properties and abundance of the components of liver carnitine palmitoyltransferases in mitochondrial inner and outer membranes. Effects of hypothyroidism, fasting and a ketotic diabetic state

Autor: E D Saggerson, Iraj Ghadiminejad

1. Liver mitochondrial outer and inner membranes were isolated from normal, 48 h-fasted, streptozotocin-diabetic and hypothyroid rats. 2. Relative to membrane protein, fasting and diabetes substantially increased the activity of carnitine palmitoyltr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9adf6b81cf67c10ad83fe37d4978a9
https://europepmc.org/articles/PMC1151285/

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Cholate separates the catalytic and malonyl-CoA-binding components of carnitine palmitoyltransferase from liver outer mitochondrial membranes

Autor: Iraj Ghadiminejad, David Saggerson

Publikováno v: Biochimica et biophysica acta. 1083(2)

Sodium cholate was used as an anionic detergent to discriminate the two components of liver overt carnitine palmitoyltransferase (CPT1); namely a catalytic entity and a regulatory component that bound malonyl-CoA. Cholate solubilized approx. 40% of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4245cf9284cc75ebd13ca80c4da09b1
https://pubmed.ncbi.nlm.nih.gov/2036450

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The relationship of rat liver overt carnitine palmitoyltransferase to the mitochondrial malonyl-CoA binding entity and to the latent palmitoyltransferase

Autor: E D Saggerson, Iraj Ghadiminejad

Publikováno v: The Biochemical journal. 270(3)

1. Confirming previous work [Murthy & Pande (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 378-382], malonyl-CoA-inhibitable carnitine palmitoyltransferase (CPT1) from rat liver was found to be localized in outer rather than in inner mitochondrial membrane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3fcc5503865a5619ef4aeab1e8b0d6
https://pubmed.ncbi.nlm.nih.gov/2241911

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