Výsledky vyhledávání - "Iraimoudi S. Ayene"

A bioactive probe for glutathione-dependent antioxidant capacity in breast cancer patients: Implications in measuring biological effects of arsenic compounds

Autor: Jie Li, Kathleen M. Ward, Pearl A. Jefferson, Iraimoudi S. Ayene, Donglan Zhang

Publikováno v: Journal of Pharmacological and Toxicological Methods. 69:39-48

Introduction Glutathione, a major cellular non-protein thiol (NPSH), serves a central role in repairing damage induced by cancer drugs, pollutants and radiation and in the detoxification of several cancer chemotherapeutic drugs and toxins. Current me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace62da85143a3e4fbd5c3b282a072bb
https://doi.org/10.1016/j.vascn.2013.10.004

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DNA as an important target in radiation-induced apoptosis of MYC and MYC plus RAS transfected rat embryo fibroblasts

Autor: Iraimoudi S. Ayene, Ruth J. Muschel, Cameron J. Koch, Robert E. Krisch, Eric J. Bernhard, W.G. McKenna

PURPOSE: This study uses a radiation chemistry approach to determine if DNA is an important target for radiation-induced apoptosis of myc (MR4) and myc plus ras (3.7) transfected rat embryo fibroblast cell lines. MATERIALS AND METHODS: The radiation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69f62e6c0968740951077a5afc3bff5
https://ora.ox.ac.uk/objects/uuid:a0c3bc3c-82b7-4f75-a70d-1f8c6bbe61ab

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Detection of Reactive Oxygen Species via Endogenous Oxidative Pentose Phosphate Cycle Activity in Response to Oxygen Concentration

Autor: John E. Biaglow, Alexander V. Kachur, Iraimoudi S. Ayene, Stephen W. Tuttle, Amit Maity, Patricia R. Oprysko, Cameron J. Koch

Publikováno v: Journal of Biological Chemistry. 282:36790-36796

The oxidative pentose phosphate cycle (OPPC) is necessary to maintain cellular reducing capacity during periods of increased oxidative stress. Metabolic flux through the OPPC increases stoichiometrically in response to a broad range of chemical oxida

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11fd3643e429371f14a2ab11bfde1909
https://doi.org/10.1074/jbc.m700327200

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DNA strand breakage by bivalent metal ions and ionizing radiation

Autor: Robert E. Krisch, Iraimoudi S. Ayene, Cameron J. Koch

Publikováno v: International Journal of Radiation Biology. 83:195-210

To investigate mechanisms of DNA breakage via the interaction of bivalent metal ion, thiol reducing agent and ionizing radiation, in *OH scavenging abilities comparable to those in cells.We measured the effects of 10 min exposure to 200 microM Fe2+ v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5990419922def54a0cb9adf4fd1e6c4b
https://doi.org/10.1080/09553000601146956

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Role of Vicinal Protein Thiols in Radiation and Cytotoxic Responses

Autor: Iraimoudi S. Ayene, John E. Biaglow, Cameron J. Koch, Jeremiah J. Donahue, Stephen W. Tuttle, John J. Mieyal

Publikováno v: Radiation Research. 165:307-317

Glutathione (GSH) and more recently protein thiols (P-SH) have been found to play a major role in cellular radiation response. However, the effects of protein vicinal thiols, which are important for the functions of several major enzymes, on cellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a7fa99538c1490765f0c640e52b6b0f
https://doi.org/10.1667/rr3505.1

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Radiation Response of Cells during Altered Protein Thiol Redox

Autor: Iraimoudi S. Ayene, Thomas D. Stamato, John E. Biaglow, Cameron J. Koch, Stephen W. Tuttle, John J. Mieyal, Jeremiah J. Donahue

Publikováno v: Radiation Research. 159:484-494

The major focus of this work was to investigate how altered protein thiol redox homeostasis affects radiation-induced cell death. We used the cells of wild-type CHO cell line K1, the CHO cell line E89, which is null for G6PD activity, and a radiation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc939bbbbc1ac20839643a133429ee2
https://doi.org/10.1667/0033-7587(2003)159[0484:rrocda]2.0.co

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Mutation in the Glucose-6-phosphate Dehydrogenase Gene Leads to Inactivation of Ku DNA End Binding during Oxidative Stress

Autor: Iraimoudi S. Ayene, Stanley K. Mauldin, Susan F. Jenkins, John E. Biaglow, Cameron J. Koch, Steven W. Tuttle, Thomas D. Stamato

Publikováno v: Journal of Biological Chemistry. 277:9929-9935

Glucose-6-phosphate dehydrogenase (G6PD), the rate-limiting enzyme of the oxidative pentose phosphate cycle, regulates the NADPH/NADP(+) ratio in eukaryotic cells. G6PD deficiency is one of the most common mutations in humans and is known to cause he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a7e74c08f5076e21f36a816efc1bd9
https://doi.org/10.1074/jbc.m111366200

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G6PD Deficient Cells and the Bioreduction of Disulfides: Effects of DHEA, GSH Depletion and Phenylarsine Oxide

Autor: Iraimoudi S. Ayene, Jerry Donahue, Stephen W. Tuttle, John E. Biaglow, Thomas D. Stamato, Cameron J. Koch

Publikováno v: Biochemical and Biophysical Research Communications. 273:846-852

We used Glucose 6 phosphate dehydrogenase (G6PD) minus cells (89 cells) and G6PD containing cells (K1) to understand the mechanisms of bioreduction of disulfide and the redox regulation of protein and non protein thiols in mammalian cells. The 89 cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a993699b68c00c3820b1f4805511ebe4
https://doi.org/10.1006/bbrc.2000.3024

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Oxidation of cellular thiols by hydroxyethyldisulphide inhibits DNA double-strand-break rejoining in G6PD deficient mammalian cells

Autor: John E. Biaglow, T. D. Stamato, M. L. Perez, Cameron J. Koch, S. W. Tuttle, Iraimoudi S. Ayene

Publikováno v: International Journal of Radiation Biology. 76:1523-1531

We investigated the effect of protein- and non protein-thiol oxidation on DNA double-strand-break (DSB) rejoining after irradiation and its relevance in the survival of CHO cells.We used mutant cells null for glucose 6 phosphate dehydrogenase (G6PD)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbfbf54b42e3c84f23b532d31bac237d
https://doi.org/10.1080/09553000050176289

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The measurement of bioreductive capacity of tumor cells using methylene blue

Autor: Yefim Manevich, Iraimoudi S. Ayene, Alexander V. Kachur, Stephen W. Tuttle, Cameron J. Koch, John E. Biaglow, Eric J. Bernhard, W. Gillies McKenna

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 42:769-773

Purpose: Methylene blue (MB) can be used as an intracellular electron acceptor. The purpose of this study was to demonstrate the usefulness of MB for the determination of total bioreductive capacity of cell suspensions. Methods and Materials: We meas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d3bc09aa05fa9ac74c202869b816e1
https://doi.org/10.1016/s0360-3016(98)00313-7

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