Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ira von Carlowitz"'
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The cytokine interleukin 1α (IL-1α) plays an important role in inflammatory processes. Here the authors use SELEX to generate a modified DNA aptamer which specifically binds IL-1α, present the structure of the IL-1α/aptamer complex and show that
Externí odkaz:
https://doaj.org/article/e2cdd527a9be48b8adaaa6d5896332bd
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications
Nature Communications
IL-1α is an essential cytokine that contributes to inflammatory responses and is implicated in various forms of pathogenesis and cancer. Here we report a naphthyl modified DNA aptamer that specifically binds IL-1α and inhibits its signaling pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7ad554b460ed72c838c22ab13926f1a
https://doaj.org/article/e2cdd527a9be48b8adaaa6d5896332bd
https://doaj.org/article/e2cdd527a9be48b8adaaa6d5896332bd
Autor:
John C. Rohloff, Daniel Schneider, Nebojsa Janjic, Jeffrey D. Carter, Bharat Gawande, Ira von Carlowitz, Chi Zhang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(11)
The nucleobases comprising DNA and RNA aptamers provide considerably less chemical diversity than protein-based ligands, limiting their versatility. The introduction of novel functional groups at just one of the four bases in modified aptamers has re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1645adc0e57ac142f08eaaeceba49752
https://pubmed.ncbi.nlm.nih.gov/28265062
https://pubmed.ncbi.nlm.nih.gov/28265062
Autor:
Eli M. Wallace, Francis X. Sullivan, Yvan Le Huerou, Stefan D. Gross, Jennifer Garrus, P LouAnn Cable, Richard Woessner, Kurtis D. Davies, Ira von Carlowitz
Publikováno v:
Cancer Biology & Therapy. 12:788-796
Inhibition of the checkpoint kinase Chk1, both as a monotherapy and in combination with DNA damaging cytotoxics, is a promising therapeutic approach for the treatment of a wide array of human cancers. However, much remains to be elucidated in regard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0494919b800bb720622467c9bd507a7e
https://doi.org/10.4161/cbt.12.9.17673
https://doi.org/10.4161/cbt.12.9.17673
Autor:
Ira von Carlowitz, Anke Klippel, Anett Schmiedeknecht, Frank Gebhardt, Klaus Giese, Anny Kretschmer, Frauke Leenders, Maria Sternberger, Leonid Beigelman, Frank Czauderna, Mike Engle
Publikováno v:
Antisense and Nucleic Acid Drug Development. 12:131-143
The study of signal transduction processes using antisense oligonucleotides is often complicated by low intracellular stability of the antisense reagents or by nonspecific effects that cause toxicity. Here, we introduce a new class of antisense molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d3f17ef82019940a1dd966ce489c33
https://doi.org/10.1089/108729002760220734
https://doi.org/10.1089/108729002760220734
Autor:
Anna M. Randi, Fiona McLaughlin, Suzy Brown, Ira von Carlowitz, Joanne M. Cox, Valerie J. Ludbrook
Publikováno v:
Blood. 98:3332-3339
It has recently been shown that the transcription factor Erg, an Ets family member, drives constitutive expression of the intercellular adhesion molecule 2 (ICAM-2) in human umbilical vein endothelial cells (HUVECs) and that its expression is down-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f990ce20523dbaa38e25cc0f669c6e
https://doi.org/10.1182/blood.v98.12.3332
https://doi.org/10.1182/blood.v98.12.3332
Publikováno v:
Molecular and General Genetics MGG. 229:453-459
The nucleotide sequence of the Escherichia coli K12 beta-methylgalactoside transport operon, mgl, was determined. Primer extension analysis indicated that the synthesis of mRNA initiates at guanine residue 145 of the determined sequence. The operon c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f15540d0587049c98ce828953d06d8
https://doi.org/10.1007/bf00267469
https://doi.org/10.1007/bf00267469
Autor:
Kristal Domenico, Ira von Carlowitz, Dennis Macejak, Nilabh Chaudhary, Andrew Conrad, Pamela Pavco, Kristi Jensen, Laurent Bellon, Sharon Jamison, Lawrence M. Blatt, Myron J. Tong, Elisabeth Roberts
Publikováno v:
Hepatology (Baltimore, Md.). 31(3)
Ribozymes are catalytic RNA molecules that can be designed to cleave specific RNA sequences. To investigate the potential use of synthetic stabilized ribozymes for the treatment of chronic hepatitis C virus (HCV) infection, we designed and synthesize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84a9a90789c91a71282665d15e2811c
https://pubmed.ncbi.nlm.nih.gov/10706571
https://pubmed.ncbi.nlm.nih.gov/10706571
Autor:
Karyn Bouhana, Steven D. Andrews, Shannon L. Winski, Taylor J. Alford, Ira von Carlowitz, Patrice Lee, Richard Woessner, Anna Gomez
Publikováno v:
Cancer Research. 72:1798-1798
The Trk family of genes, which includes trkA/NTRK1, trkB/NTRK2 and trkC/NTRK3, encode the tyrosine kinase receptors for the neurotrophin family of nerve growth factors. Deregulated kinase activity of trk family members is associated with human cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aea849058d8e42a702dfa429d39d69eb
https://doi.org/10.1158/1538-7445.am2012-1798
https://doi.org/10.1158/1538-7445.am2012-1798
Autor:
Yvan Le Huerou, Francis J. Sullivan, Eli M. Wallace, Ira von Carlowitz, Richard Woessner, Stefan Gross, Kurtis D. Davies
Publikováno v:
Cancer Research. 71:2939-2939
Inhibition of the checkpoint kinase Chk1, both as a monotherapy and in combination with DNA damaging cytotoxics, is a promising therapeutic strategy for human cancer. However, much remains to be learned in regard to the patient populations that will
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3b827ce4619f3cb56fb94d7ff0f74c1
https://doi.org/10.1158/1538-7445.am2011-2939
https://doi.org/10.1158/1538-7445.am2011-2939