Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ira S. Buckner"'
Publikováno v:
Molecular Pharmaceutics. 19:3959-3972
Specific noncovalent drug-polymer interactions were analytically identified using Raman and Fourier transform infrared spectroscopy for amorphous solid dispersions (ASD) formed between either chlorpropamide or tolbutamide and polyvinylpyrrolidone vin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a561199a0d321d37b72f073df0a3065
https://doi.org/10.1021/acs.molpharmaceut.2c00434
https://doi.org/10.1021/acs.molpharmaceut.2c00434
Publikováno v:
Molecular Pharmaceutics. 19:303-317
A molecular descriptor known as R3m (the R-GETAWAY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89deee9141cb24748719e8689fe1e8dd
https://doi.org/10.1021/acs.molpharmaceut.1c00783
https://doi.org/10.1021/acs.molpharmaceut.1c00783
Autor:
Ira S. Buckner, Rahul Roopwani
Publikováno v:
Journal of Pharmaceutical Sciences. 110:2157-2166
Deformation mechanism and strain rate sensitivity of gabapentin powder was investigated in this work. Heckel analysis, specific surface area and indentation hardness measurements revealed an intermediate yield pressure and brittle fracture as the dom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43997964a0c5f66576c166d17b2599a8
https://doi.org/10.1016/j.xphs.2020.12.021
https://doi.org/10.1016/j.xphs.2020.12.021
Publikováno v:
Journal of pharmaceutical sciences. 112(1)
Evaluation of different amorphous solid dispersion carrier matrices is enabled by active pharmaceutical ingredient (API) structure-based predictions. This study compares the utility of Hansen Solubility Parameters with the R3m molecular descriptor fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c726fc9cfc2c39285ad182b2a0155553
https://pubmed.ncbi.nlm.nih.gov/36351478
https://pubmed.ncbi.nlm.nih.gov/36351478
Publikováno v:
AAPS PharmSciTech. 21
The true density of an amorphous solid is an important parameter for studying and modeling materials behavior. Experimental measurements of density using helium pycnometry are standard but may be prevented if the material is prone to rapid recrystall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab08091e1561dac4f848fe37f9846538
https://doi.org/10.1208/s12249-020-1632-4
https://doi.org/10.1208/s12249-020-1632-4
Publikováno v:
Journal of Pharmaceutical Sciences. 107:334-343
The expansion of a novel in silico model for the prediction of the dispersability of 18 model compounds with polyvinylpyrrolidone-vinyl acetate copolymer is described. The molecular descriptor R3m (atomic mass weighted 3rd-order autocorrelation index
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b3fc3f35cdbe7a7b3867efd39d4b1d
https://doi.org/10.1016/j.xphs.2017.10.003
https://doi.org/10.1016/j.xphs.2017.10.003
Publikováno v:
AAPS PharmSciTech. 18:2570-2578
Cefuroxime axetil (CFA), an ester prodrug of cefuroxime exists as a pair of diastereoemers, namely isomer A and isomer B. To enable phase diagram construction, crystallization of the diastereomers of CFA from the commercially available amorphous drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1336bc189e00a663de0e8b61f747a275
https://doi.org/10.1208/s12249-017-0739-8
https://doi.org/10.1208/s12249-017-0739-8
Autor:
Ira S. Buckner, Rahul Roopwani
Publikováno v:
Journal of pharmaceutical sciences. 108(10)
The role of co-processing in improving tablet mechanical properties was investigated in this work. Gabapentin was used as the model compound owing to its poor tableting properties such as low tensile strength, strain rate sensitivity, high ejection f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d77236a1fbe44e07a0c1460867eed5
https://pubmed.ncbi.nlm.nih.gov/31233756
https://pubmed.ncbi.nlm.nih.gov/31233756
Publikováno v:
AAPS PharmSciTech. 18:904-912
Epithelial flux and permeability across bovine olfactory tissue were compared when levodopa (L-DOPA) was loaded in different physical states. Aqueous solution of L-DOPA was prepared in Krebs-Ringer buffer (KRB), at a concentration (0.75 mg/mL) verifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79e3a18b64e43ee429bc2dfcfa65ed8
https://doi.org/10.1208/s12249-016-0581-4
https://doi.org/10.1208/s12249-016-0581-4
Publikováno v:
Applied spectroscopy. 71(8)
Near-infrared chemical imaging (NIR-CI) combines spectroscopy with digital imaging, enabling spatially resolved analysis and characterization of pharmaceutical samples. Hardness and relative density are critical quality attributes (CQA) that affect t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e61e960618b4ebc2f2f0cfe7a1320b89
https://pubmed.ncbi.nlm.nih.gov/28756700
https://pubmed.ncbi.nlm.nih.gov/28756700