Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Ira Milosevic"'
Autor:
Udhayabhaskar Sathyanarayanan, Marina Musa, Peter Bou Dib, Nuno Raimundo, Ira Milosevic, Anita Krisko
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The sequestration of misfolded protein into insoluble aggregates occurs under conditions of proteotoxic stress. Here the authors observe that a reduction in cellular ATP promotes protein sequestration into two separate compartments: Q-bodies and stre
Externí odkaz:
https://doaj.org/article/d7329f06ba3b4892a2f5791afd48223e
Autor:
Sindhuja Gowrisankaran, Sébastien Houy, Johanna G. Peña del Castillo, Vicky Steubler, Monika Gelker, Jana Kroll, Paulo S. Pinheiro, Dirk Schwitters, Nils Halbsgut, Arndt Pechstein, Jan R. T. van Weering, Tanja Maritzen, Volker Haucke, Nuno Raimundo, Jakob B. Sørensen, Ira Milosevic
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Endophilins-A are conserved membrane-associated proteins required for endocytosis. Here, the authors report that endophilins-A also promote exocytosis of neurosecretory vesicles by coordinating priming and fusion through intersectin-1, independently
Externí odkaz:
https://doaj.org/article/d12b951e45ac43b1b8a71db762ee3203
Autor:
King Faisal Yambire, Christine Rostosky, Takashi Watanabe, David Pacheu-Grau, Sylvia Torres-Odio, Angela Sanchez-Guerrero, Ola Senderovich, Esther G Meyron-Holtz, Ira Milosevic, Jens Frahm, A Phillip West, Nuno Raimundo
Publikováno v:
eLife, Vol 8 (2019)
Lysosomal acidification is a key feature of healthy cells. Inability to maintain lysosomal acidic pH is associated with aging and neurodegenerative diseases. However, the mechanisms elicited by impaired lysosomal acidification remain poorly understoo
Externí odkaz:
https://doaj.org/article/fd107a889da64064b712d694b9b3d129
Autor:
Caterina Masaracchia, Marilena Hnida, Ellen Gerhardt, Tomás Lopes da Fonseca, Anna Villar-Pique, Tiago Branco, Markus A. Stahlberg, Camin Dean, Claudio O. Fernández, Ira Milosevic, Tiago F. Outeiro
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-17 (2018)
Abstract Alpha-synuclein (aSyn) plays a crucial role in Parkinson’s disease (PD) and other synucleinopathies, since it misfolds and accumulates in typical proteinaceous inclusions. While the function of aSyn is thought to be related to vesicle bind
Externí odkaz:
https://doaj.org/article/a7da468d38b3407296e6d3c18e9c26e7
Autor:
Franc Llorens, Katrin Thüne, Waqas Tahir, Eirini Kanata, Daniela Diaz-Lucena, Konstantinos Xanthopoulos, Eleni Kovatsi, Catharina Pleschka, Paula Garcia-Esparcia, Matthias Schmitz, Duru Ozbay, Susana Correia, Ângela Correia, Ira Milosevic, Olivier Andréoletti, Natalia Fernández-Borges, Ina M. Vorberg, Markus Glatzel, Theodoros Sklaviadis, Juan Maria Torres, Susanne Krasemann, Raquel Sánchez-Valle, Isidro Ferrer, Inga Zerr
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-21 (2017)
Abstract Background YKL-40 (also known as Chitinase 3-like 1) is a glycoprotein produced by inflammatory, cancer and stem cells. Its physiological role is not completely understood but YKL-40 is elevated in the brain and cerebrospinal fluid (CSF) in
Externí odkaz:
https://doaj.org/article/ecd452e7a5af49e1a47d32c0f9339fd5
Autor:
King Faisal Yambire, Lorena Fernandez-Mosquera, Robert Steinfeld, Christiane Mühle, Elina Ikonen, Ira Milosevic, Nuno Raimundo
Publikováno v:
eLife, Vol 8 (2019)
Perturbations in mitochondrial function and homeostasis are pervasive in lysosomal storage diseases, but the underlying mechanisms remain unknown. Here, we report a transcriptional program that represses mitochondrial biogenesis and function in lysos
Externí odkaz:
https://doaj.org/article/5deaed8285544a18bc5803384465f92b
Autor:
Udhayabhaskar Sathyanarayanan, Marina Musa, Peter Bou Dib, Nuno Raimundo, Ira Milosevic, Anita Krisko
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-020-20394-8
Externí odkaz:
https://doaj.org/article/1d636224939a4d70a434944117cc5136
Autor:
John D. Murdoch, Christine M. Rostosky, Sindhuja Gowrisankaran, Amandeep S. Arora, Sandra-Fausia Soukup, Ramon Vidal, Vincenzo Capece, Siona Freytag, Andre Fischer, Patrik Verstreken, Stefan Bonn, Nuno Raimundo, Ira Milosevic
Publikováno v:
Cell Reports, Vol 17, Iss 4, Pp 1071-1086 (2016)
Endophilin-A, a well-characterized endocytic adaptor essential for synaptic vesicle recycling, has recently been linked to neurodegeneration. We report here that endophilin-A deficiency results in impaired movement, age-dependent ataxia, and neurodeg
Externí odkaz:
https://doaj.org/article/b3675368bb464b4481786ffb5883f006
Autor:
Zohreh Farsi, Sindhuja Gowrisankaran, Matija Krunic, Burkhard Rammner, Andrew Woehler, Eileen M Lafer, Carsten Mim, Reinhard Jahn, Ira Milosevic
Publikováno v:
eLife, Vol 7 (2018)
Newly-formed synaptic vesicles (SVs) are rapidly acidified by vacuolar adenosine triphosphatases (vATPases), generating a proton electrochemical gradient that drives neurotransmitter loading. Clathrin-mediated endocytosis is needed for the formation
Externí odkaz:
https://doaj.org/article/757bbeb97ee94f8d8eaeb3c74124101c
Autor:
Ira Milosevic
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Without robust mechanisms to efficiently form new synaptic vesicles (SVs), the tens to hundreds of SVs typically present at the neuronal synapse would be rapidly used up, even at modest levels of neuronal activity. SV recycling is thus critical for s
Externí odkaz:
https://doaj.org/article/45a53bcae4ed4155851237c6644121ea