Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Ira J. Fox"'
Autor:
Marta Melis, Rebecca Marino, Jianmin Tian, Carla Johnson, Rahil Sethi, Michael Oertel, Ira J. Fox, Joseph Locker
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 3, Pp 453-479 (2024)
Background & Aims: HNF4α, a master regulator of liver development and the mature hepatocyte phenotype, is down-regulated in chronic and inflammatory liver disease. We used contemporary transcriptomics and epigenomics to study the cause and effects o
Externí odkaz:
https://doaj.org/article/270e6dc5cdb04a1fb26e7c7fe9fb3567
Autor:
Yanfeng Li, Chandan Guha, Patrik Asp, Xia Wang, Tatyana L. Tchaikovskya, Kenneth Kim, Matthew Mendel, Gregory J. Cost, David H. Perlmutter, Namita Roy-Chowdhury, Ira J. Fox, Anthony Conway, Jayanta Roy-Chowdhury
Publikováno v:
Hepatology Communications, Vol 7, Iss 3, Pp e0070-e0070 (2023)
Background:. α1-antitrypsin deficiency is most commonly caused by a mutation in exon-7 of SERPINA1 (SA1-ATZ), resulting in hepatocellular accumulation of a misfolded variant (ATZ). Human SA1-ATZ-transgenic (PiZ) mice exhibit hepatocellular ATZ accum
Externí odkaz:
https://doaj.org/article/926b6ce1dfed4900800eb27557fc5259
Autor:
Rodrigo M. Florentino, Kazutoyo Morita, Nils Haep, Takashi Motomura, Ricardo Diaz-Aragon, Lanuza A.P. Faccioli, Alexandra Collin de l’Hortet, Zeliha Cetin, Carla Frau, Lawrence Vernetti, Anna-Klara Amler, Alexander Thomas, Tobias Lam, Lutz Kloke, Kazuki Takeishi, D. Lansing Taylor, Ira J. Fox, Alejandro Soto-Gutierrez
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105503- (2022)
Summary: Advances in cellular engineering, as well as gene, and cell therapy, may be used to produce human tissues with programmable genetically enhanced functions designed to model and/or treat specific diseases. Fabrication of synthetic human liver
Externí odkaz:
https://doaj.org/article/456852f3c07c4362a0ae4b0b01b19d89
Autor:
Edgar N. Tafaleng, Amitava Mukherjee, Aaron Bell, Kazutoyo Morita, Jorge Guzman‐Lepe, Nils Haep, Rodrigo M. Florentino, Ricardo Diaz‐Aragon, Carla Frau, Alina Ostrowska, Joshua R. Schultz, Paolo G. V. Martini, Alejandro Soto‐Gutierrez, Ira J. Fox
Publikováno v:
Hepatology Communications, Vol 5, Iss 11, Pp 1911-1926 (2021)
The only definitive therapy for end‐stage liver disease is whole‐organ transplantation. The success of this intervention is severely limited by the complexity of the surgery, the cost of patient care, the need for long‐term immunosuppression, a
Externí odkaz:
https://doaj.org/article/eefaa6013f164a9e83b52ff3fa2c4cc8
Autor:
Ranjeet S. Kalsi, Alina Ostrowska, Adam Olson, Mubina Quader, Melvin Deutsch, Norma J. Arbujas-Silva, Jen Symmonds, Alejandro Soto-Gutierrez, John J. Crowley, Miguel Reyes-Mugica, Giselle Sanchez-Guerrero, Hartmut Jaeschke, Bruce P. Amiot, Marilia Cascalho, Scott L. Nyberg, Jeffrey L. Platt, Edgar N. Tafaleng, Ira J. Fox
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Acute hepatic failure is associated with high morbidity and mortality for which the only definitive therapy is liver transplantation. Some fraction of those who undergo emergency transplantation have been shown to recover native liver function when t
Externí odkaz:
https://doaj.org/article/4a6dde84b6564e42889da8c6dbe04394
Autor:
Rodrigo M. Florentino, Nicolas A. Fraunhoffer, Kazutoyo Morita, Kazuki Takeishi, Alina Ostrowska, Abhinav Achreja, Olamide Animasahun, Nils Haep, Shohrat Arazov, Nandini Agarwal, Alexandra Collin de l'Hortet, Jorge Guzman‐Lepe, Edgar N. Tafaleng, Amitava Mukherjee, Kris Troy, Swati Banerjee, Shirish Paranjpe, George K. Michalopoulos, Aaron Bell, Deepak Nagrath, Sarah J. Hainer, Ira J. Fox, Alejandro Soto‐Gutierrez
Publikováno v:
Hepatology Communications, Vol 4, Iss 6, Pp 859-875 (2020)
Hepatocyte nuclear factor 4 alpha (HNF4α) is a transcription factor that plays a critical role in hepatocyte function, and HNF4α‐based reprogramming corrects terminal liver failure in rats with chronic liver disease. In the livers of patients wit
Externí odkaz:
https://doaj.org/article/a366b3ff63454cfe85adee4824c052ae
Autor:
Kazuki Takeishi, Alexandra Collin de l’Hortet, Yang Wang, Kan Handa, Jorge Guzman-Lepe, Kentaro Matsubara, Kazutoyo Morita, Sae Jang, Nils Haep, Rodrigo M. Florentino, Fangchao Yuan, Ken Fukumitsu, Kimimasa Tobita, Wendell Sun, Jonathan Franks, Evan R. Delgado, Erik M. Shapiro, Nicolas A. Fraunhoffer, Andrew W. Duncan, Hiroshi Yagi, Tomoji Mashimo, Ira J. Fox, Alejandro Soto-Gutierrez
Publikováno v:
Cell Reports, Vol 31, Iss 9, Pp - (2020)
Summary: The availability of an autologous transplantable auxiliary liver would dramatically affect the treatment of liver disease. Assembly and function in vivo of a bioengineered human liver derived from induced pluripotent stem cells (iPSCs) has n
Externí odkaz:
https://doaj.org/article/2669d2ed58534d89a4a0eccc2bf0473f
Autor:
Yong Chen, Yanfeng Li, Xia Wang, Wei Zhang, Vanessa Sauer, Chan-Jung Chang, Bing Han, Tatyana Tchaikovskaya, Yesim Avsar, Edgar Tafaleng, Sanal Madhusudana Girija, Krisztina Tar, Zsuzsanna Polgar, Stephen Strom, Eric E. Bouhassira, Chandan Guha, Ira J. Fox, Jayanta Roy-Chowdhury, Namita Roy-Chowdhury
Publikováno v:
Stem Cell Reports, Vol 5, Iss 1, Pp 22-30 (2015)
Hepatocyte transplantation has the potential to cure inherited liver diseases, but its application is impeded by a scarcity of donor livers. Therefore, we explored whether transplantation of hepatocyte-like cells (iHeps) differentiated from human ind
Externí odkaz:
https://doaj.org/article/dfac06dc06c447ed9e5f6597ce66dbd8
Autor:
Vanessa Sauer, Tatyana Tchaikovskaya, Xia Wang, Yanfeng Li, Wei Zhang, Krisztina Tar, Zsuzsanna Polgar, Jianqiang Ding, Chandan Guha, Ira J. Fox, Namita Roy-Chowdhury, Jayanta Roy-Chowdhury
Publikováno v:
Cell Transplantation, Vol 25 (2016)
Although several types of somatic cells have been reprogrammed into induced pluripotent stem cells (iPSCs) and then differentiated to hepatocyte-like cells (iHeps), the method for generating such cells from renal tubular epithelial cells shed in huma
Externí odkaz:
https://doaj.org/article/0140d9d8c7d04cf8ba40359824a27037
Autor:
Roberto Gramignoli, Veysel Tahan, Kenneth Dorko, Raman Venkataramanan, Ira J. Fox, Ewa C. S. Ellis, Massoud Vosough, Stephen C. Strom Ph.D.
Publikováno v:
Cell Transplantation, Vol 23 (2014)
Transplantation of human hepatocytes (HTx) has gained recognition as a bridge to, or an alternative to, orthotopic liver transplantation for patients with acute liver failure or genetic defects in liver function. Although the quality of the hepatocyt
Externí odkaz:
https://doaj.org/article/6bed40ba04634a7f8187880eac103304