Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Ira J. Blader"'
Autor:
Melanie Key, Carlos Gustavo Baptista, Amy Bergmann, Katherine Floyd, Ira J. Blader, Zhicheng Dou
Publikováno v:
mSphere, Vol 9, Iss 3 (2024)
ABSTRACTToxoplasma gondii is an apicomplexan parasite that is the cause of toxoplasmosis, a potentially lethal disease for immunocompromised individuals. During in vivo infection, the parasites encounter various growth environments, such as hypoxia.
Externí odkaz:
https://doaj.org/article/3bb5dd5f40f04995be7f4ad09a60e344
Publikováno v:
mSphere, Vol 8, Iss 4 (2023)
ABSTRACT Toxoplasma gondii is an obligate intracellular parasite whose tachyzoite form causes disease via a lytic growth cycle. Its metabolic and cellular pathways are primarily designed to ensure parasite survival within a host cell. But during its
Externí odkaz:
https://doaj.org/article/820969a2d25146368110a928f95391d3
Autor:
Taylor G. Glausen, Gabriela L. Carrillo, Richard M. Jin, Jon P. Boyle, Jeroen P. J. Saeij, Elizabeth A. Wohlfert, Michael A. Fox, Ira J. Blader
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
Inflammation in the brain caused by infections lead to seizures and other neurological symptoms. But the microbial products that induce seizures as well as the host pathways downstream of these factors are largely unknown.
Externí odkaz:
https://doaj.org/article/009cc65add2f48c0955f42782c833842
Autor:
Michael J. Imperiale, Ira J. Blader
Publikováno v:
mSphere, Vol 4, Iss 5 (2019)
Externí odkaz:
https://doaj.org/article/886f00c506cc476bbc73083d3248d00e
Autor:
Celia Florimond, Charlotte Cordonnier, Rahil Taujale, Hanke van der Wel, Natarajan Kannan, Christopher M. West, Ira J. Blader
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT As the protozoan parasite Toxoplasma gondii disseminates through its host, it responds to environmental changes by altering its gene expression, metabolism, and other processes. Oxygen is one variable environmental factor, and properly adapt
Externí odkaz:
https://doaj.org/article/cce39d19a7444b7598a65d908272eb1c
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
To grow and cause disease, intracellular pathogens modulate host cell processes. Identifying these processes as well as the mechanisms used by the pathogens to manipulate them is important for the development of more effective therapeutics. As an exa
Externí odkaz:
https://doaj.org/article/b273541bc230496eaa840fb2d50df878
Publikováno v:
mSphere, Vol 2, Iss 6 (2017)
ABSTRACT Paralogs of the widely prevalent phosphoglucomutase (PGM) protein called parafusin function in calcium (Ca2+)-mediated exocytosis across eukaryotes. In Toxoplasma gondii, the parafusin-related protein 1 (PRP1) has been associated with Ca2+-d
Externí odkaz:
https://doaj.org/article/6092f150a9ed466da7694063c9ed69f2
Publikováno v:
mSphere, Vol 1, Iss 2 (2016)
ABSTRACT The urgent need to develop new antimicrobial therapies has spawned the development of repurposing screens in which well-studied drugs and other types of compounds are tested for potential off-label uses. As a proof-of-principle screen to ide
Externí odkaz:
https://doaj.org/article/68a0da91145a4c1087ed6a47bd3ce8f8
Autor:
Justin M. Brooks, Gabriela L. Carrillo, Jianmin Su, David S. Lindsay, Michael A. Fox, Ira J. Blader
Publikováno v:
mBio, Vol 6, Iss 6 (2015)
ABSTRACT During infections with the protozoan parasite Toxoplasma gondii, gamma-aminobutyric acid (GABA) is utilized as a carbon source for parasite metabolism and also to facilitate parasite dissemination by stimulating dendritic-cell motility. The
Externí odkaz:
https://doaj.org/article/d5badc021d0040e483c82c8ecb647710
Publikováno v:
mBio, Vol 6, Iss 3 (2015)
ABSTRACT Although it is established that oxygen availability regulates cellular metabolism and growth, little is known regarding how intracellular pathogens use host factors to grow at physiological oxygen levels. Therefore, large-scale human small i
Externí odkaz:
https://doaj.org/article/d82378d4294242538f637a715e6ea518