A systematic review and meta-analysis of gene therapy in animal models of cerebral glioma: why did promise not translate to human therapy?

Autor: Tc, Hirst, Hm, Vesterinen, Conlin S, Kj, Egan, Antonic A, Lawson McLean A, Malcolm Robert Macleod, Grant R, Pm, Brennan, Es, Sena, Ir, Whittle

Publikováno v: Evidence-Based Preclinical Medicine
Europe PubMed Central

Background The development of therapeutics is often characterized by promising animal research that fails to translate into clinical efficacy; this holds for the development of gene therapy in glioma. We tested the hypothesis that this is because of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::94964187425af12c7900d1e215b0ecd1
https://pubmed.ncbi.nlm.nih.gov/27668084

Gliosarcoma with areas of primitive neuroepithelial differentiation and extracranial metastasis

Autor: Sb, Wharton, Ir, Whittle, Da, Collie, Hs, Bell, James Ironside

Publikováno v: Europe PubMed Central

We report a case of gliosarcoma with areas of primitive neuroepithelial differentiation arising in the temporal lobe of a 53-year-old man. The sarcomatous component of this tumor was perivascular in its distribution and showed expression of factor VI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8683e35a543169fa77eae566c400dfde
https://pubmed.ncbi.nlm.nih.gov/12143929

INFORMAL DISCUSSION. RESEARCH REQUIREMENTS IN COASTAL ENGINEERING

Autor: D Pugh, Ir Whittle, Am Adye, I Stickland, Ls Blake, Rp Thorogood, Ph Kemp

Publikováno v: Proceedings of the Institution of Civil Engineers. 80:1434-1439

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e7595f836d336c409a1edb723af6189
https://doi.org/10.1680/iicep.1986.596

Referral pattern and management of patients with malignant brain tumours in south east Scotland

Autor: Grant R, Ir, Whittle, Da, Collie, Gregor A, James Ironside

Publikováno v: Europe PubMed Central

We reviewed hospital case notes of all incident cases of intracerebral tumours in SE Scotland to analyse referral pattern and time intervals between presentation, diagnosis and treatment. We identified 439 new patients with intracerebral tumours in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::802aac4748a122af86f75115ab0e2f22
http://europepmc.org/abstract/med/8707564

The clinical utility and reliability of surface electromyography in individuals with chronic low back pain: A systematic review.

Autor: Lathlean TJH; School of Allied Health and Practice, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide 5000, Australia; Allied Health and Human Performance, University of South Australia, City East Campus, Adelaide 5000, Australia; 3D Research at The International Spine Centre, Adelaide 5067, Australia. Electronic address: timothy.lathlean@adelaide.edu.au., Ramachandran AK; 3D Research at The International Spine Centre, Adelaide 5067, Australia; Youth Physical Development Centre, Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, United Kingdom., Sim S; Faculty of Medicine, Nursing and Health Sciences, Monash University, Victoria 3800, Australia., Whittle IR; 3D Research at The International Spine Centre, Adelaide 5067, Australia; Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide 5000, Australia; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, United Kingdom.

Publikováno v: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia [J Clin Neurosci] 2024 Nov; Vol. 129, pp. 110877. Date of Electronic Publication: 2024 Oct 19.