Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Irène Mowszowicz"'
Publikováno v:
EMC - Endocrinologie - Nutrition. 1:1-26
Publikováno v:
The Prostate. 56:192-200
BACKGROUND In prostate cancer cell lines, androgen receptor (AR) coactivators modulate the transcriptional activity of AR. However, very little is known about their expression in normal prostate tissue and during progression to cancer. METHODS AR and
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 82:297-304
TGF beta can promote and/or suppress prostate tumor growth through multiple and opposing actions. Alterations of its expression, secretion, regulation or of the sensitivity of target cells can lead to a favorable environment for tumor development. To
Publikováno v:
Molecular and Cellular Endocrinology. 174:21-30
We have previously shown that estradiol (E2) increases the growth of normal human breast epithelial (HBE) cells and the antiestrogen 4-hydroxytamoxifen (4-OHT) inhibits estrogen-induced proliferation. These effects of estrogens and antiestrogens on p
Publikováno v:
The Prostate. 46:311-318
BACKGROUND Stromal–epithelial interactions play a critical role in prostate development, but the precise mechanisms are still unknown. Transforming growth factor-beta (TGFβ) could be a potential mediator of these interactions, but there is as yet
Autor:
Sergio P. A. Toledo, Juliane Léger, Stephen Lortat-Jacob, Maguelone G. Forest, Yves Morel, Claire Nihoul-Fékété, Francis Jaubert, Rodolfo Rey, Najiba Lahlou, Claudine Lecointre, Anne Gompel, Irène Mowszowicz, Laurence Michel-Calemard, Marc Nicolino, Wolfgang Rabl, Raphaël Rappaport, Hélène Crosnier, Firdevs Bas, Nathalie Josso, Pierre Chatelain, Anne-Marie Bertrand, Nurçin Saka, Sylvie Cabrol, Corinne Belville, Claire Bouvattier, Michel David, Paul Czernichow, Sylvie Soskin
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 84:627-631
Fetal male sexual differentiation is driven by two testicular hormones: testosterone (synthesized by interstitial Leydig cells) and antimullerian hormone (AMH; produced by Sertoli cells present in the seminiferous tubules). Intersex states result eit
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 66:319-326
The regulation of the androgen receptor (AR) expression was studied using immunocytochemical and Western blot techniques on separate cultures of epithelial cells (PNT2) and fibroblasts of human prostate. In both cell types, immunocytochemistry reveal
Publikováno v:
The Prostate. 32:155-163
BACKGROUND Whereas the embryological development of the human prostate is clearly dependent on steroid 5 alpha-reductase (5 alpha-R) type 2 expression, the respective expression of the two known isoforms (types 1 and 2) of 5 alpha-R in the adult huma
Autor:
C Mestayer, Pierre Mauvais-Jarvis, Irène Mowszowicz, Marie-Claire Portois, Isabelle Berthaut, F Wright, Frédérique Kuttenn
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 81:1989-1993
Dihydrotestosterone (DHT), the 5 alpha-reduced metabolite of testosterone, is the active molecule triggering androgen action, and 5 alpha-reductase (5 alpha-R), the enzyme converting testosterone to DHT, is a key step in this mechanism. Skin, like pr
Autor:
Irène Mowszowicz
Publikováno v:
Andrologie. 5:340-346
Les androgenes utilises a des doses 10 a 100 fois superieures aux doses therapeutiques provoquent des effets qui peuvent etre classes en 4 categories: 1) Effets androgeniques: Chez l’homme, les androgenes provoquent atrophie testiculaire et azoospe