Pyrrolidine derivatives as α-amylase and α-glucosidase inhibitors: Design, synthesis, structure-activity relationship (SAR), docking studies and HSA binding

Autor: Aeyaz Ahmad Bhat, Nitin Tandon, Iqubal Singh

Publikováno v: Heliyon, Vol 10, Iss 20, Pp e39444- (2024)

In our pursuit of developing effective inhibitors for the enzymes α-amylase and α-glucosidase, which play a crucial role in carbohydrate metabolism related to type-2 diabetes, we synthesized compounds featuring a pyrrolidine ring. The synthesis inv

Externí odkaz: https://doaj.org/article/c592271ae74c42a7b6be6ca713bb8726

Marine-derived Natural Products as Anticancer Agents

Autor: Nancy, Saini, Ritika, Sirohi, Anuradha, Neetu, Saini, Pankaj, Wadhwa, Paranjeet, Kaur, Vikas, Sharma, Gurdeep, Singh, Iqubal, Singh, Sanjeev Kumar, Sahu

Publikováno v: Medicinal Chemistry. 19:538-555

Abstract: Cancer is a deadly human disease on the rise due to changes in lifestyle, nutrition, and global warming. Cancer is characterized by uncontrolled, disordered, and undesired cell division. About 60% of cancer medicines approved by the FDA are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3311fb15b20eb7ec48e9f2303313d0
https://doi.org/10.2174/1573406419666221202144044

Synthesis and photobiological applications of naphthalimide–benzothiazole conjugates: cytotoxicity and topoisomerase IIα inhibition

Autor: Iqubal Singh, Vijay Luxami, Diptiman Choudhury, Kamaldeep Paul

Publikováno v: RSC Advances. 12:483-497

Conjugates of naphthalimide, benzothiazole, and indole moieties are synthesized that show excellent cytotoxicity against A549 (lung), MCF7 (breast), and HeLa (cervix) cancer cell lines with IC50 values in the range of 0.14–8.59 μM.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc33a92f9abf5cbbd741cd42a4a72fc
https://doi.org/10.1039/d1ra04148g

List of contributors

Autor: Rose Abukhader, R.S. Agrawal, Iqrar Ahmad, Iftikhar Ali, Abdel Razzaq Al-Tawaha, Kumar Hegde Biliyaru Anand, Prasad Andhare, M. Anjaly Shanker, Kena Premshankar Anshuman, Karthik Sajith Babu, Iswar Baitharu, Satarupa Banerjee, Kuldeep Bansal, Jaya Baranwal, Mridula Saikia Barooah, Brajesh Barse, Mohammad F. Bayan, Prakash Chandra Behera, Vijeta Bhattacharya, Yeshwant R. Bhorge, Deepjyoti Bhuyan, Satpal Singh Bisht, Khalida Bloch, Balakumar Chandrasekaran, Prarthana Chatterjee, Rupali R. Chaudhary, Kajari Das, Sushma Dave, Budheswar Dehury, Urja Desai, Abhijit Dey, M. Dhanalakshmi, Amalia Di Petrillo, Navneet Kumar Dubey, Subodh Kumar Dubey, Antonella Fais, Sonia Floris, Ayushman Gadnayak, Arti Gaur, Sougata Ghosh, Namrata A. Giri, Suchetana Gupta, Surya Prakash Gupta, Anshita Gupta Soni, Namita Hegde, Mona Isaq, Mayuri Iyer, Vilas Jagatap, Sandhya Jain, C. Jayabaskaran, Renitta Jobby, Kapil Juvale, S. Abdul Kader, Aakruti Kaikini, Rahul B. Kamble, Paranjeet Kaur, Minna Kellomäki, Anandu Chandra Khanashyam, Rousan Khatun, Simran Khera, Amit Kumar, Pankaj Kumar Singh, Mohanya Kumaravel, Ganesh Latambale, Shun-Yuan Luo, Srushti Mahajan, Arabinda Mahanty, Thatikayala Mahender, Rajesh Kumar Meher, Maru Minaxi, Showkat Ahmad Mir, Monika Mishra, Namrata Mishra, Rojita Mishra, Ipsita Mohanty, Auwal Muhammad, Vaishnavi Murugan, Pradeep Kumar Naik, Sneha P. Nair, Binata Nayak, Nilesh Prakash Nirmal, Archana Padhiary, Kavita Pal, Amrita Kumari Panda, Medha Pandya, Deepa Y. Panhekar, Vijay Singh Parihar, Ramalingam Parthasarathy, Harun Patel, Viral Patel, Ashwariya Pati, Siddhartha Pati, Mayuri A. Patil, Subhaswaraj Pattnaik, Chandrappa Chinna Poojari, Alok Prasad Das, Sachin Puri, Ali Qaisi, Amreen S. Quadri, Padmalatha S. Rai, Mithun Singh Rajput, Yarappa Lakshmikant Ramachandra, R.C. Ranveer, N.B. Rathod, Manan Raval, Pooja Ravi, Rakesh Rawal, Sanjeev Kumar Sahu, Hiram Saiyed, Bhagwan K. Sakhale, Purnima Dey Sarkar, Aniket P. Sarkate, Ratnnadeep C. Sawant, Siddhi Sawant, Manas Ranjan Senapati, Asma Musfira Shabbirahmed, Radha Sharma, Mohamad Shatnawi, K. Shilali, Sonali S. Shinde, Harvinder Singh, Iqubal Singh, Sikha Singh, Subhash R. Somkuwar, Prathap Somu, D. Sruthi, Abdel Rahman Al Tawaha, Sheary Somam Tete, Pinchu Elizabath Thomas, Sirikanjana Thongmee, Priyamvada Thorakkattu, Mansi Tiwari, Kanchanlata Tungare, Dhwani Upadhyay, Vijay Upadhye, Pravin R. Vairagar, Pankaj Wadhwa, H.C. Yashavantha Rao

Publikováno v: Recent Frontiers of Phytochemicals ISBN: 9780443191435

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f3aafb3ff98fd7fd2e66c1e885717b0
https://doi.org/10.1016/b978-0-443-19143-5.00025-6

Structure-activity relationship (SAR) and antibacterial activity of pyrrolidine based hybrids: A review

Autor: Aeyaz Ahmad Bhat, Nitin Tandon, Iqubal Singh, Runjhun Tandon

Publikováno v: Journal of Molecular Structure. 1283:135175

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2125f8f997143e7538b4f00a63fc2aa3
https://doi.org/10.1016/j.molstruc.2023.135175