Evaluation of Physicochemical Properties of Ipsapirone Derivatives Based on Chromatographic and Chemometric Approaches

Autor: Wiktor Nisterenko, Damian Kułaga, Mateusz Woziński, Yash Raj Singh, Beata Judzińska, Karolina Jagiello, Katarzyna Ewa Greber, Wiesław Sawicki, Krzesimir Ciura

Publikováno v: Molecules, Vol 29, Iss 8, p 1862 (2024)

Drug discovery is a challenging process, with many compounds failing to progress due to unmet pharmacokinetic criteria. Lipophilicity is an important physicochemical parameter that affects various pharmacokinetic processes, including absorption, meta

Externí odkaz: https://doaj.org/article/dcd062956ad748c1b9940e54d419ef3f

Reduced emission of alarm 22-kHz ultrasonic vocalizations during fear conditioning in rats lacking the serotonin transporter

Autor: Judith R. Homberg, Maria Willadsen, Rainer K.W. Schwarting, Markus Wöhr, Metin Uengoer

Publikováno v: Willadsen, M, Uengoer, M, Schwarting, R K W, Homberg, J R & Wöhr, M 2021, ' Reduced emission of alarm 22-kHz ultrasonic vocalizations during fear conditioning in rats lacking the serotonin transporter ', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 108, 110072 . https://doi.org/10.1016/j.pnpbp.2020.110072
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 108

Rats display a rich social behavioral repertoire. An important component of this repertoire is the emission of whistle-like calls in the ultrasonic range, so-called ultrasonic vocalizations (USV). Long low-frequency 22-kHz USV occur in aversive situa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5367c63ccc9737124e110757b51ad4af
https://portal.findresearcher.sdu.dk/da/publications/e5e91cc0-7b10-4696-873d-364376f07270

Radioligand and computational insight in structure – Activity relationship of saccharin derivatives being ipsapirone and revospirone analogues

Autor: Jolanta Jaśkowska, Grzegorz Satała, Damian Kułaga

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 42:128028

Schizophrenia and depression are diseases that significantly impede human functioning in society. Current antidepressant drugs are not fully effective. According to literature data, the effect on D2R or 5-HT1AR can effectively reduce the symptoms of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1abf463950f1673876204443a65cc5
https://doi.org/10.1016/j.bmcl.2021.128028

Azapirone 5-HT1A receptor partial agonist treatment for major depressive disorder: systematic review and meta-analysis

Autor: Taro Kishi, Herbert Y. Meltzer, Yuki Matsuda, Nakao Iwata

Publikováno v: Psychological Medicine. 44:2255-2269

BackgroundA meta-analysis of the serotonin1A (5-HT1A) receptor partial agonist of the azapirone class as an anxiolytic drug for the treatment of major depressive disorder (MDD) has not previously been reported.MethodWe carried out a systematic review

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875e5cfd0cb076445fe9ed33f053e519
https://doi.org/10.1017/s0033291713002857

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