Total synthesis of lissodendoric acid A via stereospecific trapping of a strained cyclic allene.

Autor: Ippoliti, Francesca M.¹, Adamson, Nathan J.¹, Wonilowicz, Laura G.¹, Nasrallah, Daniel J.¹, Darzi, Evan R.¹, Donaldson, Joyann S.¹, Garg, Neil K.¹ neilgarg@chem.ucla.edu

Publikováno v: Science. 1/20/2023, Vol. 379 Issue 6629, p261-265. 5p. 4 Color Photographs.

Cell-Free Total Biosynthesis of Plant Terpene Natural Products Using an Orthogonal Cofactor Regeneration System

Autor: Bat-Erdene, Undramaa, Billingsley, John M., Turner, William C., Lichman, Benjamin R., Ippoliti, Francesca M., Garg, Neil K., O'Connor, Sarah E., Tang, Yi

Here we report the one-pot, cell-free enzymatic synthesis of the plant monoterpene nepetalactol starting from the readily available geraniol. A pair of orthogonal cofactor regeneration systems permitted NAD+-dependent geraniol oxidation followed by N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::d1dd406a79eae23f08dff2cc8bb3e518
https://eprints.whiterose.ac.uk/179781/1/Cell_Free_Final_submitted_version.pdf

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Cell-Free Total Biosynthesis of Plant Terpene Natural Products using an Orthogonal Cofactor Regeneration System.

Autor: Bat-Erdene U; Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA., Billingsley JM; Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA., Turner WC; Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA., Lichman BR; Centre for Agricultural Products, Department of Biology, University of York, Wentworth Way, York, YO10 5DD, UK., Ippoliti FM; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA., Garg NK; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA., O'Connor SE; Department of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Hans-Knöll-Straße 8, 07745 Jena, Germany., Tang Y; Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, USA.; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA, USA.

Publikováno v: ACS catalysis [ACS Catal] 2021 Aug 06; Vol. 11 (15), pp. 9898-9903. Date of Electronic Publication: 2021 Jul 23.