Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ippei Usui"'
Autor:
Sonia Mediouni, Krishna Chinthalapudi, Mary K. Ekka, Ippei Usui, Joseph A. Jablonski, Mark A. Clementz, Guillaume Mousseau, Jason Nowak, Venkat R. Macherla, Jacob N. Beverage, Eduardo Esquenazi, Phil Baran, Ian Mitchelle S. de Vera, Douglas Kojetin, Erwann P. Loret, Kendall Nettles, Souvik Maiti, Tina Izard, Susana T. Valente
Publikováno v:
mBio, Vol 10, Iss 1 (2019)
ABSTRACT The intrinsically disordered HIV-1 Tat protein binds the viral RNA transactivation response structure (TAR), which recruits transcriptional cofactors, amplifying viral mRNA expression. Limited Tat transactivation correlates with HIV-1 latenc
Externí odkaz:
https://doaj.org/article/602de632323a423fab4a3dba4bf5eaf7
Autor:
Krishna Chinthalapudi, Douglas J. Kojetin, Jacob Neal Beverage, Souvik Maiti, Sonia Mediouni, Erwann P. Loret, Guillaume Mousseau, Ippei Usui, Tina Izard, Susana T. Valente, Jason Nowak, Kendall W. Nettles, Ian Mitchelle S. de Vera, Joseph A. Jablonski, Eduardo Esquenazi, Venkat R. Macherla, Phil S. Baran, Mark A. Clementz, Mary Krishna Ekka
Publikováno v:
mBio, Vol 10, Iss 1, p e02662-18 (2019)
mBio, Vol 10, Iss 1 (2019)
mBio
mBio, Vol 10, Iss 1 (2019)
mBio
Tat activates virus production, and limited Tat transactivation correlates with HIV-1 latency. The Tat inhibitor dCA locks HIV in persistent latency. This drug class enables block-and-lock functional cure approaches, aimed at reducing residual viremi
Publikováno v:
Advanced Synthesis & Catalysis. 355:2071-2075
The Ru-catalyzed hydroformylation of a variety of terminal alkenes is demonstrated to proceed under mild reaction conditions using the self-assembling ligand PTS.
Publikováno v:
Organic Letters. 15:2080-2083
The first synthesis of members of the sarcodonin family, phellodonin and sarcodonin ε, is reported herein. This verifies that the unprecedented and seemingly unstable N,N-dioxide-containing benzodioxazine framework can be constructed in the laborato
Publikováno v:
Angewandte Chemie. 124:11659-11663
Our laboratory has a longstanding interest in harvesting new chemical knowledge by learning from terpene biosynthesis. The straightforward construction of carbocyclic terpene backbones such as epoxy-germacrenol (1, Scheme 1A) in a low oxidation state
Publikováno v:
Chemistry - A European Journal. 17:8555-8558
Diphenylphosphinite is applied as a catalytic directing group in the selective hydroformylation reaction leading to synthetically valuable α,α-disubstituted butyrolactones.
Publikováno v:
Organic Letters. 13:612-615
A phosphinite plays a role as a reversibly bound directing group for the regio- and diastereoselective hydroformylation of 2,5-cyclohexadienyl-1-carbinols. Of the two alkene functions only one was functionalized through hydroformylation to form a syn
Publikováno v:
ORGANIC & BIOMOLECULAR CHEMISTRY. 8(18):4169-4175
A series of cyclobutenes bearing group 14 elements at the 3-position were synthesized, and their thermal ring-opening reactions were studied. Carbon-substituted cyclobutene underwent the ring-opening reaction through an outward pathway to afford the
Publikováno v:
Organic Letters. 11:1453-1456
The dual Pd/proline-catalyzed alpha-allylation reaction of a variety of enolizable ketones and aldehydes with allylic alcohols is described. In this reaction, the choice of a large-bite angle ligand Xantphos and proline as the organocatalyst was esse
Publikováno v:
PURE AND APPLIED CHEMISTRY. 78(2):415-423
The silyl substituent of 3-silylcyclobutene prefers inward rotation rather than outward rotation during a thermal ring-opening reaction, giving the Z-isomer predominantly. This intriguing behavior was explained by assuming electron-accepting interact