Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ippei Sato"'
Autor:
Takayuki Imaoka, Shin-ichi Tsukamoto, Tatsuaki Morokata, Ippei Sato, Makoto Takeuchi, Toshiya Takahashi, Yosuke Iura, Hideki Inoue, Mitsuaki Ohta, Hirokazu Kubota, Aiko Nitta, Koichiro Morihira
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6876-6881
Optimization starting with our lead compound 1 (IC(50)=4.9 nM) led to the identification of pyrrolidinyl phenylurea derivatives. Further modification toward improvement of the bioavailability provided (R)-1-(1-((6-fluoronaphthalen-2-yl)methyl)pyrroli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684ca3932de13368c29c0080b36dffca
https://doi.org/10.1016/j.bmcl.2012.09.035
https://doi.org/10.1016/j.bmcl.2012.09.035
Autor:
Shin-ichi Tsukamoto, Makoto Takeuchi, Toshiya Takahashi, Yosuke Iura, Mitsuaki Ohta, Koichiro Morihira, Ippei Sato, Takayuki Imaoka, Aiko Nitta, Tatsuaki Morokata, Hirokazu Kubota, Hiroki Tomioka
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4951-4954
The synthesis and structure–activity relationships of ureas as CCR3 antagonists are described. Optimization starting with lead compound 2 (IC50 = 190 nM) derived from initial screening hit compound 1 (IC50 = 600 nM) led to the identification of (S)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb48c86d02b5241b9554d192a5f0da5a
https://doi.org/10.1016/j.bmcl.2012.06.042
https://doi.org/10.1016/j.bmcl.2012.06.042
Autor:
Takahiro Kuramochi, Issei Tsukamoto, Shuichi Sakamoto, Taku Taguchi, Akio Kakefuda, Ippei Sato
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:717-724
The sodium-calcium exchanger (NCX) transports Na+ and Ca2+ ions, and controls the Ca2+ concentration in myocytes. Calcium overload is induced via activation of reverse NCX, and is responsible for reperfusion injury in heart failure. Hence, NCX is an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72eb8b86cd4707725c90d989a0c4efa
https://doi.org/10.1016/j.bmc.2004.10.047
https://doi.org/10.1016/j.bmc.2004.10.047
Autor:
Ippei Sato, Shuichi Sakamoto, Taku Taguchi, Akio Kakefuda, Hiroyoshi Yamada, Takahiro Kuramochi
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:5039-5056
The sodium–calcium exchanger (NCX) is known as the transporter that controls the concentration of Ca2+ in cardiac myocytes. In the setting of heart failure and myocardial ischemia-reperfusion, NCX underlies an arrhythmogenic transient inward curren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2432a86d9caa1f538acfb236414232ef
https://doi.org/10.1016/j.bmc.2004.07.038
https://doi.org/10.1016/j.bmc.2004.07.038
Autor:
Takeshi Terauchi, Taro Terauchi, Naoki Kanoh, Tomoharu Tsukada, Ippei Sato, Takashi Tsunoda, Wataru Shoji, Masaya Nakata
Publikováno v:
Tetrahedron Letters. 44:7741-7745
The Mukaiyama aldol coupling of the second-generation C1C14 (AB) fragment of altohyrtins (spongistatins) with the model α-methyl-β-alkoxyaldehydes revealed that the stereochemistry at the newly formed carbon centers was controlled by the β-alko
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27fee48ae7fded285adcace82133c918
https://doi.org/10.1016/j.tetlet.2003.08.082
https://doi.org/10.1016/j.tetlet.2003.08.082
Autor:
Kyoko Kimijima, Masataka Morita, Masaya Nakata, Takashi Tsunoda, Gouichirou Hayashi, Ippei Sato, Yasuhiro Nakamura, Naoki Kanoh, Tomoharu Tsukada, Taisaku Tanaka, Taro Terauchi, Wataru Shoji, Takeshi Terauchi
Publikováno v:
Tetrahedron Letters. 44:7747-7751
Coupling of the C1C14 (AB) crotylstannane with the C15C28 (CD) aldehyde followed by stereochemical arrangements gave the C1C28 (ABCD) fragment of altohyrtin C. The C29C44 (EF) fragment was also prepared. The syntheses of these two fragmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f39d039db297d211201d54e400c5c7b5
https://doi.org/10.1016/j.tetlet.2003.08.083
https://doi.org/10.1016/j.tetlet.2003.08.083
Publikováno v:
Tetrahedron Letters. 41:2649-2653
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cdc96e73230680396aa323e65742602a
https://doi.org/10.1016/s0040-4039(00)00237-9
https://doi.org/10.1016/s0040-4039(00)00237-9
Autor:
Keiko Suzuki, Ippei Sato, Makoto Takeuchi, Tatsuaki Morokata, Kazuki Ohno, Yosuke Iura, Koichiro Morihira, Hirokazu Kubota, Hiroshi Inami, Toshiya Takahashi, Mitsuaki Ohta, Takayuki Imaoka, Aiko Nitta, Shin-ichi Tsukamoto
Publikováno v:
Bioorganicmedicinal chemistry. 17(16)
Our laboratory has identified several acrylamide derivatives with potent CCR3 inhibitory activity. In the present study, we evaluated the in vitro metabolic stability (CLint; mL/min/kg) of these compounds in human liver microsomes (HLMs), and assesse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c24e30afa0c8a4330a7bcf4e6b2ac3
https://pubmed.ncbi.nlm.nih.gov/19620010
https://pubmed.ncbi.nlm.nih.gov/19620010
Autor:
Tatsuaki Morokata, Hirokazu Kubota, Keiko Suzuki, Takayuki Imaoka, Koichiro Morihira, Yosuke Iura, Mitsuaki Ohta, Toshiya Takahashi, Makoto Takeuchi, Aiko Nitta, Hiroshi Inami, Shin-ichi Tsukamoto, Ippei Sato
Publikováno v:
Bioorganicmedicinal chemistry. 16(18)
In our previous study on discovering novel types of CCR3 antagonists, we found a fluoronaphthalene derivative (1) that exhibited potent CCR3 inhibitory activity with an IC50 value of 20 nM. However, compound 1 also inhibited human cytochrome P450 2D6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b7d143ea2970d4d8a561dfa2e0c2aa
https://pubmed.ncbi.nlm.nih.gov/18752960
https://pubmed.ncbi.nlm.nih.gov/18752960
Autor:
Noritaka Hamada, Yosuke Iura, Mitsuaki Ohta, Tatsuaki Morokata, Toshiya Takahashi, Koichiro Morihira, Makoto Takeuchi, Keiko Suzuki, Ippei Sato, Takayuki Imaoka, Shin-ichi Tsukamoto, Aiko Nitta, Hiroshi Inami, Hirokazu Kubota
Publikováno v:
Bioorganicmedicinal chemistry. 16(1)
A novel class of potent CCR3 receptor antagonists were designed and synthesized starting from N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide (1),which was found by subjecting our chemical library to high throughput screening (HTS). The CC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69bd8c0c913a20c26f3cb2121b1bfde
https://pubmed.ncbi.nlm.nih.gov/17951061
https://pubmed.ncbi.nlm.nih.gov/17951061