Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Iphigenie Korakis"'
Autor:
François Poumeaud, Marion Jaffrelot, Carlos Gomez-Roca, Iphigénie Korakis, Giulia Leonardi, Marine Joly, Julien Mazières, Rosine Guimbaud, Nadim Fares, Emily Alouani
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Selective rearranged during transfection (RET) tyrosine kinase inhibitor, pralsetinib, demonstrated clinical efficacy and was well tolerated in lung and thyroid cancers with RET gene mutations or fusions in clinical trials. While the latter focused o
Externí odkaz:
https://doaj.org/article/7c0a2cbae1364c2c8e3c5e5ecb44573d
Autor:
Sophie Cousin, Coralie Cantarel, Jean-Philippe Guegan, Thibault Mazard, Carlos Gomez-Roca, Jean-Philippe Metges, Carine Bellera, Antoine Adenis, Iphigenie Korakis, Pierre-Guillaume Poureau, Kevin Bourcier, Maud Toulmonde, Michèle Kind, Christophe Rey, Céline Auzanneau, Alban Bessede, Isabelle Soubeyran, Antoine Italiano
Publikováno v:
European Journal of Cancer. 162:161-169
Regorafenib has shown substantial clinical activity in patients with advanced biliary tract cancers (BTCs). Preclinical data suggested that this drug modulates antitumour immunity and is synergistic with immune checkpoint inhibition.This is a single-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25cabf6fbb005d4230cf86dd9e46f62c
https://doi.org/10.1016/j.ejca.2021.11.012
https://doi.org/10.1016/j.ejca.2021.11.012
Autor:
Stéphane Champiat, Philippe A. Cassier, Nuria Kotecki, Carlos Gomez-Roca, Iphigenie Korakis, Ouali Kaissa, Antoine Italiano, Mabrouk M. Elgadi, Thomas Vandewalle, Isabelle Girault, Nina Salabert-Le Guen, Donogh O’Brien, Nicolas Poirier, Bérangère Vasseur, Dominique Costantini, Claudia Fromond, Françoise Bono, Jean-Pierre Delord
Publikováno v:
Cancer Research. 83:2129-2129
Background: Signal Regulatory Protein α [SIRPα] is an inhibitory membrane receptor expressed by myeloid cells (macrophages and myeloid-derived suppressor cells, MDSCs) and specifically binds to CD47. BI765063 is a selective anti-SIRPα monoclonal a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::929ce79085421e3bd7b5f2755e2fd14f
https://doi.org/10.1158/1538-7445.am2023-2129
https://doi.org/10.1158/1538-7445.am2023-2129
Autor:
Noemie Gadaud, Carlos Gomez Roca, Loic Ysebaert, Aurore Perrot, Myriam Estrabaut, Muriel Poublanc, Iphigenie Korakis, Christian Recher, Jean Pierre Delord, Thomas Filleron, Pierre Bories
Publikováno v:
Blood. 140:5045-5046
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc9890d4c7d80aedb50038c30b41c030
https://doi.org/10.1182/blood-2022-167063
https://doi.org/10.1182/blood-2022-167063
Autor:
Joel B. Epstein, Ariadna Ortiz Brugués, Carlos Gomez-Roca, Caroline de Bataille, Béatrice Herbault-Barres, Emmanuelle Vigarios, Iphigenie Korakis, Sarah Betrian, Vincent Sibaud
Publikováno v:
The Oncologist. 25:e391-e395
Commenting on a recently published article on sicca syndrome linked to immune checkpoint inhibitor therapy, this letter to the editor shares another viewpoint on the management of this immune-related adverse event.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f6368cb28308067b6661dec15857fae
https://doi.org/10.1634/theoncologist.2019-0467
https://doi.org/10.1634/theoncologist.2019-0467
Autor:
Stephane Champiat, Aurelien Marabelle, Vladimir Galvao, Patricia LoRusso, Peter Grell, Philippe Cassier, Carlos Gomez-Roca, Iphigenie Korakis, Aung Naing, Lenka Palova Jelinkova, Irena Adkins, Ulrich Moebius, Richard Sachse, Sascha Tillmanns, David Bechard, Joachim Kiemle-Kallee, Elena Garralda
Publikováno v:
Cancer Research. 82:CT040-CT040
Introduction: SOT101 (previously SO-C101), a fusion protein of IL-15 and the IL-15 receptor α sushi+ domain, was investigated in an open-label, multicenter, dose-escalation study as monotherapy and in combination with pembrolizumab in patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f78b76206d89cd856d8458d873a4d51
https://doi.org/10.1158/1538-7445.am2022-ct040
https://doi.org/10.1158/1538-7445.am2022-ct040
Autor:
Elena Garralda, Aung Naing, Vladimir Galvao, Patricia LoRusso, Peter Grell, Philippe Alexandre Cassier, Carlos A. Gomez-Roca, Iphigenie Korakis, David Bechard, Lenka Palova Jelinkova, Irena Adkins, Sascha Tillmanns, Joachim Kiemle-Kallee, Aurelien Marabelle, Stephane Champiat
Publikováno v:
Journal of Clinical Oncology. 40:2502-2502
2502 Background: SOT101 (previously SO-C101) is a fusion protein of IL-15 and the IL-15 receptor α sushi+ domain. Synergistic effects of SOT101 and an anti-programmed cell death protein 1 antibody have been validated in various tumor mouse models in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dde2fcba9d0f2837119dfa217484d482
https://doi.org/10.1200/jco.2022.40.16_suppl.2502
https://doi.org/10.1200/jco.2022.40.16_suppl.2502
Autor:
Stéphane Champiat, Philippe A. Cassier, Jon Blatchford, Mabrouk Elgadi, Armelle Vinceneux, Nuria Kotecki, Christiane Jungels, Jean-Pierre Delord, Bérangère Vasseur, Nicole Clarke, Iphigenie Korakis, Aurélien Marabelle, Claudia Fromond, Nicolas Poirier
Publikováno v:
Journal of Clinical Oncology. 39:2623-2623
2623 Background: BI 765063 is a humanized IgG4 monoclonal antibody antagonist of SIRPα (Signal Regulatory Protein α), which blocks the “don't eat me” signal of the SIRPα/CD47 axis, a critical innate immune checkpoint. SIRPα is expressed on my
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2ac1c1eb8e2cf6ce48a98cfada4cf93
https://doi.org/10.1200/jco.2021.39.15_suppl.2623
https://doi.org/10.1200/jco.2021.39.15_suppl.2623
Autor:
Thibault Mazard, Carine Bellera, Iphigenie Korakis, Isabelle Soubeyran, Sophie Cousin, Jean Philippe Guégan, Carlos Gomez-Roca, Pierre-Guillaume Poureau, Antoine Italiano, Jean Philippe Metges, Coralie Cantarel, Michèle Kind, Antoine Adenis, Alban Bessede, Mariella spalato-Ceruso, Kevin Bourcier
Publikováno v:
Journal of Clinical Oncology. 39:4096-4096
4096 Background: Regorafenib (R) has shown promising efficacy in patients (pts) with BTC refractory to standard chemotherapy. Anti-PD1/PD-L1 antibodies have only limited clinical activity. Synergy between R and anti–PD-1/PD-L1 antibodies has been s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d661d16dfec8897e5f050c5fae4dcd12
https://doi.org/10.1200/jco.2021.39.15_suppl.4096
https://doi.org/10.1200/jco.2021.39.15_suppl.4096
Autor:
Bérangère Vasseur, Nuria Kotecki, Aurélien Marabelle, Iphigenie Korakis, Richard D. Huhn, Philippe A. Cassier, Christiane Jungels, Dominique Costantini, Jean-Pierre Delord, Armelle Vinceneux, Stéphane Champiat, Nicolas Poirier
Publikováno v:
Blood. 134:1040-1040
Introduction: Signal Regulatory Protein α [SIRPα] is a polymorphic protein, strongly expressed on myeloid suppressive cells. BI 765063 (OSE172), a humanized IgG4 monoclonal antibody (mAb), is a selective antagonist of SIRPα/CD47 interaction, it do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0b10e14a70d7d2d97476ad0d10320b9
https://doi.org/10.1182/blood-2019-124876
https://doi.org/10.1182/blood-2019-124876