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The clinical utility and costs of whole-genome sequencing to detect cancer susceptibility variants-a multi-site prospective cohort study.

Autor: Davidson AL; QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Brisbane, QLD, Australia.; Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia., Dressel U; Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia., Norris S; Faculty of Medicine and Health, University of Sydney, L2.22 The Quadrangle (A14), Sydney, NSW, 2006, Australia., Canson DM; QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Brisbane, QLD, Australia.; Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia., Glubb DM; QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Brisbane, QLD, Australia.; Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia., Fortuno C; QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Brisbane, QLD, Australia.; Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia., Hollway GE; QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Brisbane, QLD, Australia., Parsons MT; QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Brisbane, QLD, Australia., Vidgen ME; QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Brisbane, QLD, Australia.; Australian Genomics, Melbourne, VIC, Australia., Holmes O; QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Brisbane, QLD, Australia., Koufariotis LT; QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Brisbane, QLD, Australia., Lakis V; QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Brisbane, QLD, Australia., Leonard C; QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Brisbane, QLD, Australia., Wood S; QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Brisbane, QLD, Australia., Xu Q; QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Brisbane, QLD, Australia., McCart Reed AE; Centre for Clinical Research, University of Queensland, Brisbane, QLD, Australia., Pickett HA; Children's Medical Research Institute, University of Sydney, Westmead, NSW, Australia., Al-Shinnag MK; Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia.; Genetic Health Queensland, Royal Brisbane and Women's Hospital, Herston, QLD, Australia., Austin RL; Australian Genomics, Melbourne, VIC, Australia.; Genetic Health Queensland, Royal Brisbane and Women's Hospital, Herston, QLD, Australia., Burke J; Tasmanian Clinical Genetics Service, Royal Hobart Hospital, Hobart, TAS, Australia., Cops EJ; Parkville Familial Cancer Centre, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, VIC, Australia., Nichols CB; Genetic Services of Western Australia, King Edward Memorial Hospital, Subiaco, WA, Australia., Goodwin A; Cancer Genetics Department, Royal Prince Alfred Hospital, Sydney, NSW, Australia.; University of Sydney, Sydney, NSW, Australia., Harris MT; Monash Health Familial Cancer, Monash Health, Melbourne, VIC, Australia.; Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia., Higgins MJ; Genetic Health Queensland, Royal Brisbane and Women's Hospital, Herston, QLD, Australia., Ip EL; Cancer Genetics, Liverpool Hospital, Sydney, NSW, Australia., Kiraly-Borri C; Department of Health, Genetic Services of WA, Subiaco, WA, Australia., Lau C; Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia.; Genomics, Pathology Queensland, Brisbane, QLD, Australia., Mansour JL; Tasmanian Clinical Genetics Service, Royal Hobart Hospital, Hobart, TAS, Australia., Millward MW; Tasmanian Clinical Genetics Service, Royal Hobart Hospital, Hobart, TAS, Australia., Monnik MJ; Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, SA, Australia., Pachter NS; Genetic Services of Western Australia, King Edward Memorial Hospital, Subiaco, WA, Australia.; Faculty of Health and Medical Sciences, University of Western Australia, Perth, WA, Australia., Ragunathan A; Familial Cancer Services, The Crown Princess Mary Cancer Centre, Westmead Hospital, Westmead, NSW, Australia., Susman RD; Genetic Health Queensland, Royal Brisbane and Women's Hospital, Herston, QLD, Australia., Townshend SL; Genetic Services of Western Australia, King Edward Memorial Hospital, Subiaco, WA, Australia., Trainer AH; Parkville Familial Cancer Centre, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, VIC, Australia.; Department of Medicine, University of Melbourne, Melbourne, VIC, Australia., Troth SL; Genetic Health Queensland, Royal Brisbane and Women's Hospital, Herston, QLD, Australia., Tucker KM; Prince of Wales Clinical School, UNSW Medicine and Health, The University of New South Wales, Sydney, NSW, Australia.; Hereditary Cancer Centre, Prince of Wales Hospital, Sydney, NSW, Australia., Wallis MJ; Tasmanian Clinical Genetics Service, Royal Hobart Hospital, Hobart, TAS, Australia.; School of Medicine and Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia., Walsh M; Parkville Familial Cancer Centre, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, VIC, Australia., Williams RA; Prince of Wales Clinical School, UNSW Medicine and Health, The University of New South Wales, Sydney, NSW, Australia.; Hereditary Cancer Centre, Prince of Wales Hospital, Sydney, NSW, Australia., Winship IM; Department of Medicine, University of Melbourne, Melbourne, VIC, Australia.; Genomic Medicine and Familial Cancer Clinic, Royal Melbourne Hospital, Melbourne, VIC, Australia., Newell F; QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Brisbane, QLD, Australia., Tudini E; QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Brisbane, QLD, Australia.; Australian Genomics, Melbourne, VIC, Australia., Pearson JV; QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Brisbane, QLD, Australia., Poplawski NK; Adult Genetics Unit, Royal Adelaide Hospital, Adelaide, SA, Australia.; Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, SA, Australia., Mar Fan HG; Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia.; Genetic Health Queensland, Royal Brisbane and Women's Hospital, Herston, QLD, Australia., James PA; Parkville Familial Cancer Centre, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, VIC, Australia.; Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, VIC, Australia., Spurdle AB; QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Brisbane, QLD, Australia. amanda.spurdle@qimrberghofer.edu.au.; Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia. amanda.spurdle@qimrberghofer.edu.au., Waddell N; QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston QLD 4006, Brisbane, QLD, Australia.; Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia., Ward RL; Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia. robyn.ward@sydney.edu.au.; Faculty of Medicine and Health, University of Sydney, L2.22 The Quadrangle (A14), Sydney, NSW, 2006, Australia. robyn.ward@sydney.edu.au.

Publikováno v: Genome medicine [Genome Med] 2023 Sep 19; Vol. 15 (1), pp. 74. Date of Electronic Publication: 2023 Sep 19.