Interferon lambda 4 impacts broadly on hepatitis C virus diversity

Autor: Graham R. Foster, A da Silva Filipe, John McLauchlan, A Ansari, William L. Irving, V Pedergnana, Connor G. G. Bamford, Eleanor Barnes, Paul Klenerman, Rory Bowden, L S Hin, Spencer Cca., Amy Trebes, Vanessa M. Cowton, Elihu Aranday-Cortes, Arvind H. Patel, Christopher Holmes, Emma Hudson, Kosh Agarwal, E. Thomson, Peter Simmonds, Ip Clc., Vattipally B. Sreenu, Paolo Piazza, David Bonsall

Type III interferons (IFN-λ) are part of the innate immune response to hepatitis C virus (HCV) infection however the specific role of IFN-λ4 and the nature of the viral adaption to this pressure have not been defined. Here we use paired genome-wide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9629832809174165f7287955dc8a266b

Resistance analysis of genotype 3 hepatitis C virus indicates subtypes inherently resistant to nonstructural protein 5A inhibitors

Autor: David A. Smith, Andrea Magri, Rory Bowden, David Bonsall, Peter Simmonds, Anthony Brown, Eleanor Barnes, Ip Clc., Paolo Piazza, M A Ansari, D Nguyen, Amy Trebes

Publikováno v: Hepatology (Baltimore, Md.)

Hepatitis C virus (HCV) genotype (gt) 3 is highly prevalent globally, with non-gt3a subtypes common in Southeast Asia. Resistance-associated substitutions (RASs) have been shown to play a role in treatment failure. However, the role of RASs in gt3 is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db3901ea549eb24c8ec6a234797fbb7
https://pubmed.ncbi.nlm.nih.gov/29425396

A pilot study of rapid benchtop sequencing of Staphylococcus aureus and Clostridium difficile for outbreak detection and surveillance

Autor: Daniel J. Wilson, Ip Clc., Angela Kearns, N C Gordon, Anne-Sophie Walker, Elizabeth M. Batty, Mark H. Wilcox, Peto Tea., R Lay, Peter Donnelly, Lily O’Connor, John E. Paul, Xavier Didelot, Rory Bowden, David Buck, Paolo Piazza, David W Eyre, Derrick W. Crook, Tanya Golubchik, A Shaw

Publikováno v: BMJ Open

Objectives To investigate the prospects of newly available benchtop sequencers to provide rapid whole-genome data in routine clinical practice. Next-generation sequencing has the potential to resolve uncertainties surrounding the route and timing of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd84a50f25aec4413c3bafd024edf2b8
https://doi.org/10.1136/bmjopen-2012-001124

Comparison of next generation sequencing technologies for the comprehensive assessment of full-length hepatitis C viral genomes

Autor: Ip, CLC, Ansari, MA, Brown, A, Bowden, R, Bonsall, D, Hudson, E, Klenerman, P, Piazza, P, Trebes, A, Barnes, E, Simmonds, P, STOP-HCV Consortium

Publikováno v: Journal of Clinical Microbiology. 54(10)

Affordable next generation sequencing (NGS) technologies for hepatitis C virus (HCV) may potentially identify both viral genotype and resistance genetic motifs in the era of directly acting anti-viral (DAA) therapies. This study compared the ability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1064::9f2cf15524a9a601659319609e445cf1
http://ora.ox.ac.uk/objects/uuid:11a2d9c8-3203-4444-81e8-9ccc67ddc061

Technical Validation of a Hepatitis C Virus Whole Genome Sequencing Assay for Detection of Genotype and Antiviral Resistance in the Clinical Pathway.

Autor: Manso CF; Public Health England, London, United Kingdom., Bibby DF; Public Health England, London, United Kingdom., Lythgow K; Public Health England, London, United Kingdom., Mohamed H; Public Health England, London, United Kingdom., Myers R; Public Health England, London, United Kingdom., Williams D; Public Health England, London, United Kingdom., Piorkowska R; Public Health England, London, United Kingdom., Chan YT; Public Health England, London, United Kingdom., Bowden R; The Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Ansari MA; The Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Peter Medawar Building for Pathogen Research and the NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Ip CLC; The Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Barnes E; Peter Medawar Building for Pathogen Research and the NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom., Bradshaw D; Public Health England, London, United Kingdom., Mbisa JL; Public Health England, London, United Kingdom.; National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Blood Borne and Sexually Transmitted Infections, London, United Kingdom.

Publikováno v: Frontiers in microbiology [Front Microbiol] 2020 Oct 09; Vol. 11, pp. 576572. Date of Electronic Publication: 2020 Oct 09 (Print Publication: 2020).