Specific involvement of tyrosine 764 of human granulocyte colony- stimulating factor receptor in signal transduction mediated by p145/Shc/GRB2 or p90/GRB2 complexes

Autor: JP de Koning, AM Schelen, F Dong, C van Buitenen, BM Burgering, JL Bos, B Lowenberg, IP Touw

Publikováno v: Blood. 87:132-140

Signal transduction from the granulocyte colony-stimulating factor receptor (G-CSF-R) occurs via multiple pathways, one of which involves activation of p21Ras and mitogen-activated protein kinase. The SH2 domain-containing proteins Shc and GRB2 have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78a126d07fc03afb9c52a782b825e4c2
https://doi.org/10.1182/blood.v87.1.132.bloodjournal871132

Tumor necrosis factor regulates the expression of granulocyte- macrophage colony-stimulating factor and interleukin-3 receptors on human acute myeloid leukemia cells

Autor: O Elbaz, LM Budel, H Hoogerbrugge, IP Touw, R Delwel, LA Mahmoud, B Lowenberg

Publikováno v: Blood. 77:989-995

Tumor necrosis factor (TNF) acts as a potent enhancer of granulocyte- macrophage colony-stimulating factor (GM-CSF)- and interleukin-3 (IL-3)- induced human acute myeloid leukemia (AML) growth in vitro. We have analyzed the effects of TNF alpha on th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3be6ff86f12cd12ff0d84e8818f7a72
https://doi.org/10.1182/blood.v77.5.989.bloodjournal775989

Proliferation signaling and activation of Shc, p21Ras, and Myc via tyrosine 764 of human granulocyte colony-stimulating factor receptor

Autor: Jp, Koning, Aa, Soede-Bobok, Am, Schelen, Smith L, van Leeuwen D, VALERIA SANTINI, Bm, Burgering, Jl, Bos, Lowenberg B, Ip, Touw

Publikováno v: Europe PubMed Central

The membrane-distal region of the cytoplasmic domain of human granulocyte colony-stimulating factor receptor (G-CSF-R) contains four conserved tyrosine residues: Y704, Y729, Y744, and Y764. Three of these (Y729, Y744, and Y764) are located in the C-t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::03639949ad0e4affd0ea91e1e78222d5
https://pubmed.ncbi.nlm.nih.gov/9490675

Interleukin-3 and granulocyte-monocyte colony-stimulating factor receptors on human acute myelocytic leukemia cells and relationship to the proliferative response

Autor: LM Budel, IP Touw, R Delwel, SC Clark, B Lowenberg

Publikováno v: Blood. 74(2)

Interleukin-3 (IL-3) and granulocyte-monocyte-colony-stimulating factor (GM-CSF) stimulate proliferation of human acute myeloid leukemia (AML) in vitro, although patterns of response among clinical cases are diverse. Whether regulatory abnormalities

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3e81ba2a4e46c1c3ce0602c2a69b36
https://pubmed.ncbi.nlm.nih.gov/2546627

RUNX1 is required in granulocyte-monocyte progenitors to attenuate inflammatory cytokine production by neutrophils.

Autor: Zezulin AU; Department of Cell and Developmental Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Yen D; Department of Cell and Developmental Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Ye D; Department of Radiation Oncology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Howell ED; Department of Cell and Developmental Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Bresciani E; Oncogenesis and Development Section, Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Diemer J; Oncogenesis and Development Section, Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Ren JG; Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Ahmad MH; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA., Castilla LH; Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA., Touw IP; Department of Hematology, Erasmus Medical College, Rotterdam 3015CN, the Netherlands., Minn AJ; Department of Radiation Oncology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Tong W; Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA., Liu PP; Oncogenesis and Development Section, Division of Intramural Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA., Tan K; Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.; Division of Oncology and Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA., Yu W; Department of Pediatrics, Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; nancyas@upenn.edu yuw1@chop.edu.; Division of Oncology and Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA., Speck NA; Department of Cell and Developmental Biology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA; nancyas@upenn.edu yuw1@chop.edu.

Publikováno v: Genes & development [Genes Dev] 2023 Jul 01; Vol. 37 (13-14), pp. 605-620. Date of Electronic Publication: 2023 Aug 03.