Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Iou-Jiun Kang"'
Autor:
Iou-Jiun Kang, 康祐竣
91
In recent years, hypervalent iodine reagents have attracted much attention as useful synthetic reagents. These hypervalent iodine reagents have been extensively used in organic synthesis due to their low toxicity and easy handling. In the fam
In recent years, hypervalent iodine reagents have attracted much attention as useful synthetic reagents. These hypervalent iodine reagents have been extensively used in organic synthesis due to their low toxicity and easy handling. In the fam
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/60798122509855669779
Autor:
Iou-Jiun Kang, 康祐竣
87
The Pummerer reaction of sulfoxides normally proceeds via an activated sulfoxide and then a thionium ion which reacts with a nucleophile at carbon to afford an -substituted sulfide. In an interrupted Pummerer reaction, the tricoordinate su
The Pummerer reaction of sulfoxides normally proceeds via an activated sulfoxide and then a thionium ion which reacts with a nucleophile at carbon to afford an -substituted sulfide. In an interrupted Pummerer reaction, the tricoordinate su
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/56725982283357958854
Autor:
Sheng-Ju Hsu, Yen-Chun Lee, Iou-Jiun Kang, Jen-Shin Song, Teng-Kuang Yeh, Yu-Sheng Chao, Ya-Wen Tian, Chung-Chi Lee, Hui-Yun Yang, Jyh-Haur Chern, Andrew Yueh, Tsu-An Hsu
Publikováno v:
Journal of Medicinal Chemistry. 60:228-247
Starting from the initial lead 4-phenylthiazole 18, a modest HCV inhibitor (EC50 = 9440 nM), a series of structurally related thiazole derivatives has been identified as a novel chemical class of potent and selective HCV NS5A inhibitors. The introduc
Autor:
Teng-Kuang Yeh, Jyh-Haur Chern, Andrew Yueh, Chung-Chi Lee, Sheng-Ju Hsu, Chiung-Tong Chen, Yu-Sheng Chao, Hui-Yun Yang, Yen-Chun Lee, Tsu-An Hsu, Ya-Wen Tian, Iou-Jiun Kang
Publikováno v:
European journal of medicinal chemistry. 167
A medicinal chemistry program based on the small-molecule HCV NS5A inhibitor daclatasvir has led to the discovery of dimeric phenylthiazole compound 8, a novel and potent HCV NS5A inhibitor. The subsequent SAR studies and optimization revealed that t
Publikováno v:
Journal of the Chinese Chemical Society. 59:535-539
The synthesis of substituted quinolines can be easily and greenly accomplished by the direct reaction between the corresponding aminoalcohol and ketone using PEG-400 as reaction medium in the presence of a base, without any transition-metal catalyst.
Publikováno v:
Journal of the Chinese Chemical Society. 58:663-666
PEG-400[poly(ethylene glycol-400)] is used as reaction medium in the one-pot synthesis of 6-arylimidazo[2,1-b]thiazoles by reaction with aryl ketones, hypervalent iodine(III) sulfonate and 2-aminothiazole. Significant rate enhancements and improved y
Publikováno v:
Chemico-Biological Interactions. 188:228-236
Increasing evidence indicates that microglial activation plays an important role in the pathogenesis of Alzheimer's disease (AD). In AD, activated microglia may facilitate the clearance of beta-amyloid (Abeta), a neurotoxic component in AD pathogenes
Publikováno v:
Journal of the Chinese Chemical Society. 57:153-156
Iodobenzene-catalyzed synthesis of imidazo[1,2-a]pyridines from aryl ketones with mCPBA as a cooxidant in ionic liquid is described. The method is simple, rapid and practical, generating Imidazo[1,2-a]pyridines from the aryl ketone without isolation
Autor:
Tsu-An Hsu, Jyh-Haur Chern, Yen-Shian Wu, Andrew Yueh, Li-Wen Wang, Iou-Jiun Kang, Yen-Chun Lee, Jing-Chyi Wang, Sheng-Ju Hsu, Chung-Chi Lee, Yu-Sheng Chao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:6063-6068
A novel class of arylthiourea HCV inhibitors bearing various functionalities, such as cyclic urea, cyclic thiourea, urea, and thiourea, on the alkyl linker were designed and synthesized. Herein we report the synthesis and structure-activity relations
Publikováno v:
Journal of the Chinese Chemical Society. 56:867-872
A mild and efficient route for the synthesis of quinolines and polycyclic quinolines utilizing Gadolinium triflate (Gd(OTf) 3 ) as a novel catalyst via Friedlander annulation in ionic liquid 1-n-butyl-3-methylimidazolium hexafluorophosphate [Bmim][PF