Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ioscani Jimenez del Val"'
Autor:
Philip M. Jedrzejewski, Ioscani Jimenez del Val, Antony Constantinou, Anne Dell, Stuart M. Haslam, Karen M. Polizzi, Cleo Kontoravdi
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 3, Pp 4492-4522 (2014)
Glycoproteins represent the largest group of the growing number of biologically-derived medicines. The associated glycan structures and their distribution are known to have a large impact on pharmacokinetics. A modelling framework was developed to pr
Externí odkaz:
https://doaj.org/article/2c60d957ade844d28a3c0a256127cedd
Autor:
Cleo Kontoravdi, Karen M. Polizzi, Stuart M. Haslam, Ioscani Jimenez del Val, Itzcóatl A. Gómez, Roberto Donini, Pavlos Kotidis, Masue Marbiah
Recombinant monoclonal antibodies bind specific molecular targets and, subsequently, induce an immune response or inhibit the binding of other ligands. However, monoclonal antibody functionality and half-life may be reduced by the type and distributi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e382a6890fa515ae8d929522c4ed86c2
http://hdl.handle.net/10044/1/97896
http://hdl.handle.net/10044/1/97896
Autor:
Pavlos Kotidis, Roberto Donini, Johnny Arnsdorf, Anders Holmgaard Hansen, Bjørn Gunnar Rude Voldborg, Austin W.T. Chiang, Stuart M. Haslam, Michael Betenbaugh, Ioscani Jimenez del Val, Nathan E. Lewis, Frederick Krambeck, Cleo Kontoravdi
Publikováno v:
Kotidis, P, Donini, R, Arnsdorf, J, Hansen, A H, Voldborg, B G R, Chiang, A W T, Haslam, S M, Betenbaugh, M, Jimenez del Val, I, Lewis, N E, Krambeck, F & Kontoravdi, C 2022, ' CHOGlycoNET: Comprehensive glycosylation reaction network for CHO cells ', Metabolic Engineering, vol. 76, pp. 87-96 . https://doi.org/10.1016/j.ymben.2022.12.009
Chinese hamster ovary (CHO) cells are extensively used for the production of glycoprotein therapeutics proteins, for which N-linked glycans are a critical quality attribute due to their influence on activity and immunogenicity. Manipulation of protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c4ce3ae7c163ab17f6d45976286d5d
https://orbit.dtu.dk/en/publications/e3b57c88-ddef-4b08-a8b0-0490f1e1b7ba
https://orbit.dtu.dk/en/publications/e3b57c88-ddef-4b08-a8b0-0490f1e1b7ba
Autor:
Pavlos, Kotidis, Masue, Marbiah, Roberto, Donini, Itzcóatl A, Gómez, Ioscani Jimenez, Del Val, Stuart M, Haslam, Karen M, Polizzi, Cleo, Kontoravdi
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2370
The impact of the glycan distribution on the in vivo function and half-life of monoclonal antibodies has long motivated the genetic engineering of producer cells to achieve structures that enhance efficacy, safety and stability. To facilitate glycoen
Autor:
Pavlos Kotidis, Karen M. Polizzi, Ioscani Jimenez del Val, Cleo Kontoravdi, Stuart M. Haslam, Itzcóatl A Gómez, Masue Marbiah, Roberto Donini
Publikováno v:
Glycosylation ISBN: 9781071616840
The impact of the glycan distribution on the in vivo function and half-life of monoclonal antibodies has long motivated the genetic engineering of producer cells to achieve structures that enhance efficacy, safety and stability. To facilitate glycoen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f849a58cc56ce81834fc0ba029cf599e
https://doi.org/10.1007/978-1-0716-1685-7_7
https://doi.org/10.1007/978-1-0716-1685-7_7
Autor:
Ioscani Jimenez del Val, Benjamin Strain, Rodrigo Barbosa, Athanasios Antonakoudis, Cleo Kontoravdi
In-process quality control of biotherapeutics, such as monoclonal antibodies, requires computationally efficient process models that use readily measured process variables to compute product quality. Existing kinetic cell culture models can effective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e095f89cc33ecc76e371062d925f9841
http://hdl.handle.net/10044/1/90764
http://hdl.handle.net/10044/1/90764
Autor:
Nathan E Lewis, Iman Shahidi Pour Savizi, Ehsan Motamedian, Seyed Abbas Shojaosadati, Ioscani Jimenez del Val
Publikováno v:
Biotechnology journalREFERENCES. 16(8)
Monoclonal antibodies (mABs) have emerged as one of the most important therapeutic recombinant proteins in the pharmaceutical industry. Their immunogenicity and therapeutic efficacy are influenced by post-translational modifications, specifically the
Publikováno v:
Current Opinion in Chemical Engineering. 32:100691
Monoclonal antibodies (mAbs) are the highest-selling class of biopharmaceuticals due to their capabilities in treating severe illnesses. Thus, strategies to optimise their manufacture have been at the centre of recent academic and industrial research
Publikováno v:
Bioengineering, Vol 11, Iss 6, p 546 (2024)
Large-scale bioprocesses are increasing globally to cater to the larger market demands for biological products. As fermenter volumes increase, the efficiency of mixing decreases, and environmental gradients become more pronounced compared to smaller
Externí odkaz:
https://doaj.org/article/a717466ea73d41028873af2b5898ec90
Publikováno v:
Biochemical Engineering Journal. 158:107576
Polyethylene terephthalate (PET) is a major contributor to plastic pollution due to its widespread presence in synthetic fibres. As an intermediate in the chemical recycling of PET, disodium terephthalate (Na2TA) can be harnessed as a cheap microbial