Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Iori Murai"'
Autor:
Haytham Mohamed Aly Mohamed, Akinori Takahashi, Saori Nishijima, Shungo Adachi, Iori Murai, Hitoshi Okamura, Tadashi Yamamoto
Publikováno v:
RNA Biology, Vol 19, Iss 1, Pp 703-718 (2022)
Circadian clocks are an endogenous internal timekeeping mechanism that drives the rhythmic expression of genes, controlling the 24 h oscillatory pattern in behaviour and physiology. It has been recently shown that post-transcriptional mechanisms are
Externí odkaz:
https://doaj.org/article/2375c3d520754f9d911e76b4d0913564
Autor:
Yoshiaki Yamaguchi, Iori Murai, Kaoru Goto, Shotaro Doi, Huihua Zhou, Genzui Setsu, Hiroyuki Shimatani, Hitoshi Okamura, Takahito Miyake, Masao Doi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Gpr19 encodes an evolutionarily conserved orphan G-protein-coupled receptor (GPCR) with currently no established physiological role in vivo. We characterized Gpr19 expression in the suprachiasmatic nucleus (SCN), the locus of the master circ
Externí odkaz:
https://doaj.org/article/fa41915671cb49aa8c6c451ead7970fe
Autor:
Masao Doi, Hiroyuki Shimatani, Yuta Atobe, Iori Murai, Hida Hayashi, Yukari Takahashi, Jean-Michel Fustin, Yoshiaki Yamaguchi, Hiroshi Kiyonari, Nobuya Koike, Kazuhiro Yagita, Choogon Lee, Manabu Abe, Kenji Sakimura, Hitoshi Okamura
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
The circadian transcription factors BMAL1:CLOCK bind to E/E′-boxes in gene regulatory elements of their targets and facilitate rhythmic expression. Here, the authors mutate the Per2 promoter E’′-box in mice and observe that cell- and tissue-aut
Externí odkaz:
https://doaj.org/article/9f27d452176741a7b1daf82753a71800
Autor:
Masao Doi, Iori Murai, Sumihiro Kunisue, Genzui Setsu, Naohiro Uchio, Rina Tanaka, Sakurako Kobayashi, Hiroyuki Shimatani, Hida Hayashi, Hsu-Wen Chao, Yuuki Nakagawa, Yukari Takahashi, Yunhong Hotta, Jun-ichirou Yasunaga, Masao Matsuoka, Michael H. Hastings, Hiroshi Kiyonari, Hitoshi Okamura
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The suprachiasmatic nucleus (SCN) is the central regulator of circadian rhythms. Here the authors identify mouse Gpr176 as a pace modulator of this circadian clock and characterize its mode of action as coupling to Gz rather than Gi subunits.
Externí odkaz:
https://doaj.org/article/c16b11b6441e475eb897bd5b32fd2eac
Autor:
Yoshiaki, Yamaguchi, Iori, Murai, Momoko, Takeda, Shotaro, Doi, Takehito, Seta, Reiko, Hanada, Kenji, Kangawa, Hitoshi, Okamura, Takahito, Miyake, Masao, Doi
Publikováno v:
Biologicalpharmaceutical bulletin. 45(8)
The suprachiasmatic nucleus (SCN) is the master circadian clock in mammals and is properly entrained by environmental light cycle. However, the molecular mechanism(s) determining the magnitude of phase shift by light is still not fully understood. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e890825891099f40c9b677760bc04527
https://pubmed.ncbi.nlm.nih.gov/35908898
https://pubmed.ncbi.nlm.nih.gov/35908898
Autor:
Kojiro Tsujihana, Kosuke Tanegashima, Yasuko Santo, Hiroyuki Yamada, Sota Akazawa, Ryuta Nakao, Keiko Tominaga, Risa Saito, Yasumasa Nishito, Ryu-Ichiro Hata, Tomonori Nakamura, Iori Murai, Yuka Kono, Maho Sugawa, Miki Tanioka, Gyohei Egawa, Masao Doi, Tadashi Isa, Kenji Kabashima, Takahiko Hara, Hitoshi Okamura
Publikováno v:
Proceedings of the National Academy of Sciences (PNAS). 119(25)
The epidermis is the outermost layer of the skin and the body’s primary barrier to external pathogens; however, the early epidermal immune response remains to be mechanistically understood. We show that the chemokine CXCL14, produced by epidermal k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c3800fdfdc37c839492a8a5a79c746
http://hdl.handle.net/2433/277870
http://hdl.handle.net/2433/277870
Autor:
Masao Doi, Genzui Setsu, Yoshiaki Yamaguchi, Kaoru Goto, Takahito Miyake, Iori Murai, Huihua Zhou, Hiroyuki Shimatani, Hitoshi Okamura, Shotaro Doi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Background and Purpose: Gpr19 encodes an evolutionarily conserved orphan G-protein-coupled receptor (GPCR) with no established physiological function in vivo. The purpose of this study was to determine the role of Gpr19 in the circadian clock system.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de87319876d67e1ffc5c2981c92020bc
http://hdl.handle.net/2433/276730
http://hdl.handle.net/2433/276730
Autor:
Masao Doi, Hiroyuki Shimatani, Tadahiro Goda, Yujiro Umezaki, Victoria H. Nguyen, Michelle L. Chu, Hitoshi Okamura, Fumika N. Hamada, Iori Murai
Publikováno v:
Genes & Development. 32:140-155
Daily body temperature rhythm (BTR) is essential for maintaining homeostasis. BTR is regulated separately from locomotor activity rhythms, but its molecular basis is largely unknown. While mammals internally regulate BTR, ectotherms, including Drosop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f07dd91689b724897baa2ea444868f6
https://doi.org/10.1101/gad.307884.117
https://doi.org/10.1101/gad.307884.117
Publikováno v:
Endocrine Journal. 64:571-579
G-protein-coupled receptors (GPCRs) constitute an immensely important class of drug targets with diverse clinical applications. There are still more than 120 orphan GPCRs whose cognate ligands and physiological functions are not known. A set of circa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb6d136669c27f19aee4723545e530f
https://doi.org/10.1507/endocrj.ej17-0130
https://doi.org/10.1507/endocrj.ej17-0130
Autor:
Mohamed, Haytham Mohamed Aly, Akinori Takahashi, Saori Nishijima, Shungo Adachi, Iori Murai, Hitoshi Okamura, Tadashi Yamamoto
Publikováno v:
RNA Biology; Jan2022, Vol. 19 Issue 1, p703-718, 16p