Zobrazeno 1 - 10
of 3 795
pro vyhledávání: '"Ionotropic effect"'
Autor:
Massimo Avoli, Maxime Lévesque
Publikováno v:
Current Neuropharmacology. 20:1704-1716
GABA, the key inhibitory neurotransmitter in the adult forebrain, activates pre- and postsynaptic receptors that have been categorized as GABAA, which directly open ligand-gated (or receptor-operated) ion-channels, and GABAB, which are metabotropic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6fee488d8e7c12f735fc09bad98548c
https://doi.org/10.2174/1570159x19666210823102332
https://doi.org/10.2174/1570159x19666210823102332
Autor:
Kate Poole
Publikováno v:
Annual Review of Physiology. 84:307-329
Many aspects of mammalian physiology are mechanically regulated. One set of molecules that can mediate mechanotransduction are the mechanically activated ion channels. These ionotropic force sensors are directly activated by mechanical inputs, result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960542c6e8ba30a242a52870e430cbae
https://doi.org/10.1146/annurev-physiol-060721-100935
https://doi.org/10.1146/annurev-physiol-060721-100935
Autor:
Daniel F. Gilbert, Martin James Stebbing, Katharina Kuenzel, Robyn Murphy, Evelyn Zacharewicz, Andreas Buttgereit, Leanne Stokes, David J. Adams, Oliver Friedrich
Publikováno v:
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Vol 9 (2016)
Frontiers in Molecular Neuroscience, Vol 9 (2016)
Microglia activation is a neuroinflammatory response to parenchymal damage with release of intracellular metabolites, e.g., purines, and signaling molecules from damaged cells. Extracellular purines can elicit Ca(2+)-mediated microglia activation inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6de05ea1c623f95690cbc20c2f43c83
Autor:
Rashid Giniatullin
Publikováno v:
British Journal of Pharmacology. 179:400-415
5-hydroxytryptamine (5-HT; serotonin) is traditionally considered as a key mediator implicated in migraine. Multiple 5-HT receptor subtypes contribute to a variety of region-specific functional effects. The raphe nuclei control nociceptive inputs by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e5ddf00541a5b2fdb8945e7f7ec026f
https://doi.org/10.1111/bph.15710
https://doi.org/10.1111/bph.15710
Autor:
Adam Gorlewicz, Christophe Mulle, Grzegorz M. Wilczynski, Stefano Zucca, Peggy Vincent, Marilena Griguoli, Noelle Grosjean, Gaël Barthet
Publikováno v:
Cerebral Cortex
Cerebral Cortex, Oxford University Press (OUP), 2021, ⟨10.1093/cercor/bhab390⟩
Cerebral Cortex, Oxford University Press (OUP), 2021, ⟨10.1093/cercor/bhab390⟩
Kainate receptors (KARs) are key regulators of synaptic circuits by acting at pre- and postsynaptic sites through either ionotropic or metabotropic actions. KARs can be activated by kainate, a potent neurotoxin, which induces acute convulsions. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae698449e15d93f5150a3af9c46cb78
https://doi.org/10.1093/cercor/bhab390
https://doi.org/10.1093/cercor/bhab390
Publikováno v:
Insect Science. 29:657-668
Ionotropic receptors (IRs) were first found in Drosophila melanogaster, and derive from ionotropic glutamate receptors (iGluRs), which are implicated in detecting acids, ammonia, amine, temperature and humidity. Although IRs are involved in sensing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d1e6f58ed9e0a362a0e7c2d3d941281
https://doi.org/10.1111/1744-7917.12962
https://doi.org/10.1111/1744-7917.12962
Autor:
Tao Tang, Yi-Chi Zhang, Ke-Xin Zhang, Lin-Lin Zheng, Zhong-Qiang Jia, Di Liu, Chun-Qing Zhao, Ying Wang
Publikováno v:
Pest Management Science. 78:603-611
Neuroligin (NLG) protein is a nerve cell adhesion molecule and plays a key role in the precision apposition of presynaptic domains on inhibitory and excitatory synapses. Existing studies mainly focused on the function of NLG3 against the excitatory c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb451e27716389de8c488f69169977bd
https://doi.org/10.1002/ps.6669
https://doi.org/10.1002/ps.6669
Autor:
Olivia M. Schmit, Ryan O. Walters, Christina D. Orrú, Anna Smith, James A. Carroll, Catharine M. Bosio, Wen-Quan Zou, Simote T. Foliaki, Benjamin Schwarz, Aleksandar Wood, Natália Ferreira, Bradley R. Groveman, Jue Yuan, Phoebe Freitag, Cathryn L. Haigh
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-23 (2021)
Molecular Brain
Molecular Brain
The neuro-physiological properties of individuals with genetic pre-disposition to neurological disorders are largely unknown. Here we aimed to explore these properties using cerebral organoids (COs) derived from fibroblasts of individuals with confir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::001765cd00a47b4f15e93d71e69793d6
https://doaj.org/article/6bd0dd66c2cd46cbb517d6bd6b03291d
https://doaj.org/article/6bd0dd66c2cd46cbb517d6bd6b03291d
Autor:
Cheng Wang Sheng, Andrew K. Jones, Chun Qing Zhao, Tao Tang, Zhaojun Han, Jie Jiang, Qiu Tang Huang
Publikováno v:
Journal of Agricultural and Food Chemistry. 69:11582-11591
The ionotropic γ-aminobutyric acid (iGABA) receptor is commonly considered as a fast inhibitory channel and is an important insecticide target. Since 1990, RDL, LCCH3, and GRD have been successively isolated and found to be potential subunits of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e82db077a53cbe4ed77973b203b96f0
https://doi.org/10.1021/acs.jafc.1c00385
https://doi.org/10.1021/acs.jafc.1c00385
Autor:
Mary Ann Andrade, Aline A. Mourão, Glenn M. Toney, Caroline G. Shimoura, Tamara T. Truong, Gustavo Rodrigues Pedrino
Publikováno v:
Am J Physiol Heart Circ Physiol
Tumor necrosis factor-α (TNFα) in the hypothalamic paraventricular nucleus (PVN) contributes to increased sympathetic nerve activity (SNA) in cardiovascular disease models, but mechanisms are incompletely understood. As previously reported, bilater
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f9ed267697fac86952484e12477382
https://doi.org/10.1152/ajpheart.00322.2021
https://doi.org/10.1152/ajpheart.00322.2021