Intrinsic defects in erythroid cells from familial hemophagocytic lymphohistiocytosis type 5 patients identify a role for STXBP2/Munc18-2 in erythropoiesis and phospholipid scrambling

Autor: Rob van Zwieten, Elena Kostova, Boukje M. Beuger, Martijn Veldthuis, Timo K. van den Berg, Emile van den Akker, Robin van Bruggen, Ingrid Kühnle, Jutte van der Werff ten Bosch

Publikováno v: Kostova, E B, Beuger, B M, Veldthuis, M, van der Werff Ten Bosch, J, Kühnle, I, van den Akker, E, van den Berg, T K, van Zwieten, R & van Bruggen, R 2015, ' Intrinsic defects in erythroid cells from familial hemophagocytic lymphohistiocytosis type 5 patients identify a role for STXBP2/Munc18-2 in erythropoiesis and phospholipid scrambling ', Experimental Hematology, vol. 43, no. 12, pp. 1072-1076.e2 . https://doi.org/10.1016/j.exphem.2015.08.007
Experimental Hematology, 43(12), 1072-1076.e2. Elsevier Inc.
Experimental hematology, 43(12), 1072-1076. Elsevier Inc.

Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is a rare genetic disorder caused by mutations in STXBP2/Munc18-2. Munc18-2 plays a role in the degranulation machinery of natural killer cells and cytotoxic T lymphocytes. Mutations in STXBP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db82022f1b59f2fd913da4ae3cc9d7c
https://doi.org/10.1016/j.exphem.2015.08.007

Identification of signalling cascades involved in red blood cell shrinkage and vesiculation

Autor: Timo K. van den Berg, Elena Kostova, Robin van Bruggen, Pasi Halonen, Thomas R. L. Klei, Boukje M. Beuger, Cor Lieftink, Roderick L. Beijersbergen

Publikováno v: Bioscience Reports
Bioscience Reports, Vol 35, Iss 2, p e00187 (2015)
Kostova, E B, Beuger, B M, Klei, T R L, Halonen, P, Lieftink, C, Beijersbergen, R, van den Berg, T K & van Bruggen, R 2015, ' Identification of signalling cascades involved in red blood cell shrinkage and vesiculation ', Frontiers in Bioscience, vol. 35, no. 2 . https://doi.org/10.1042/BSR20150019
Frontiers in Bioscience, 35(2). Frontiers in Bioscience
Bioscience reports, 35(2). Portland Press Ltd.

Even though red blood cell (RBC) vesiculation is a well-documented phenomenon, notably in the context of RBC aging and blood transfusion, the exact signalling pathways and kinases involved in this process remain largely unknown. We have established a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7eaf893b837cb3d5e683e1beaee15c2
https://pubmed.ncbi.nlm.nih.gov/25757360

Calreticulin reveals a critical Ca2+ checkpoint in cardiac myofibrillogenesis

Autor: Marek Michalak, Karl-Heinz Krause, Marisa Jaconi, Carmen Perez-Terzic, Michel Pucéat, Jian Li, Annabelle Méry, Kimitoshi Nakamura

Publikováno v: The Journal of Cell Biology
The Journal of Cell Biology, Vol. 158, No 1 (2002) pp. 103-113

Calreticulin (crt) is an ubiquitously expressed and multifunctional Ca(2+)-binding protein that regulates diverse vital cell functions, including Ca(2+) storage in the ER and protein folding. Calreticulin deficiency in mice is lethal in utero due to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41722e37775bc6528a10c6738a04bc8d
http://europepmc.org/articles/PMC2173019

Cellular functions and X-ray structure of anthrolysin O, a cholesterol-dependent cytolysin secreted by Bacillus anthracis

Autor: Richard F. Rest, Raymond W. Bourdeau, Mitch L. Villereal, Enrico Malito, Wei-Jen Tang, Alexandre Chenal, Eugene B. Chang, Mark W. Musch, Elise M. Mosser, Brian L. Bishop

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2009, 284 (21), pp.14645-14656. ⟨10.1074/jbc.M807631200⟩
Journal of Biological Chemistry, 2009, 284 (21), pp.14645-14656. ⟨10.1074/jbc.M807631200⟩

International audience; Anthrolysin O (ALO) is a pore-forming, cholesterol-dependent cytolysin (CDC) secreted by Bacillus anthracis, the etiologic agent for anthrax. Growing evidence suggests the involvement of ALO in anthrax pathogenesis. Here, we s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1793df6fcebc99126dcd9422abef133f
https://hal-pasteur.archives-ouvertes.fr/pasteur-01540766

NOX5 is expressed at the plasma membrane and generates superoxide in response to protein kinase C activation

Autor: Karl-Heinz Krause, Karen Bedard, Nicolas Demaurex, Lena Serrander, Oliver Hartley, Serge Arnaudeau, Vincent Jaquet, Werner Schlegel, Olivier Plastre

Publikováno v: Biochimie, Vol. 89, No 9 (2007) pp. 1159-1167

NOX5 is a ROS-generating NADPH oxidase which contains an N-terminal EF-hand region and can be activated by cytosolic Ca(2+) elevations. However the C-terminal region of NOX5 also contains putative phosphorylation sites. In this study we used HEK cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2557843dd9d31ac8d2a1247682ba629
https://archive-ouverte.unige.ch/unige:11583