DeepFoci: Deep learning-based algorithm for fast automatic analysis of DNA double-strand break ionizing radiation-induced foci

Autor: Tomas Vicar, Jaromir Gumulec, Radim Kolar, Olga Kopecna, Eva Pagacova, Iva Falkova, Martin Falk

Publikováno v: Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 6465-6480 (2021)

DNA double-strand breaks (DSBs), marked by ionizing radiation-induced (repair) foci (IRIFs), are the most serious DNA lesions and are dangerous to human health. IRIF quantification based on confocal microscopy represents the most sensitive and gold-s

Externí odkaz: https://doaj.org/article/c0b88efe98ac477199d807379bd6c73f

A Paradigm Revolution or Just Better Resolution—Will Newly Emerging Superresolution Techniques Identify Chromatin Architecture as a Key Factor in Radiation-Induced DNA Damage and Repair Regulation?

Autor: Michael Hausmann, Martin Falk

Publikováno v: Cancers, Vol 13, Iss 18, p 18 (2021)
Cancers

Simple Summary Radiation-induced double-strand breaks (DSBs) are the most toxic and most difficult to repair DNA lesions and are very heterogeneous. These characteristics place considerable demands on the selection of the most suitable repair mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df2ca2baf875db9ee575704de007ea41
https://doi.org/10.3390/cancers13010018

A Paradigm Revolution or Just Better Resolution-Will Newly Emerging Superresolution Techniques Identify Chromatin Architecture as a Key Factor in Radiation-Induced DNA Damage and Repair Regulation?

Autor: Falk M; Institute of Biophysics, The Czech Academy of Sciences, 612 65 Brno, Czech Republic., Hausmann M; Kirchhoff Institute for Physics, Heidelberg University, 69120 Heidelberg, Germany.

Publikováno v: Cancers [Cancers (Basel)] 2020 Dec 23; Vol. 13 (1). Date of Electronic Publication: 2020 Dec 23.