Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Ionica Masgras"'
Autor:
Francesco Ciscato, Ionica Masgras, Alessandro Gori, Marco Fantuz, Greta Bergamaschi, Denis Komarov, Martina La Spina, Shiva Ghasemi-Firouzabadi, Marco Pizzi, Angelo Paolo Dei Tos, Federica Chiara, Alessandro Carrer, Andrea Rasola
Publikováno v:
Cells, Vol 13, Iss 13, p 1162 (2024)
Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are aggressive sarcomas that can arise both sporadically and in patients with the genetic syndrome Neurofibromatosis type 1 (NF1). Prognosis is dismal, as large dimensions, risk of relapse, and anatom
Externí odkaz:
https://doaj.org/article/b92cb213e59a4815bded7afee2dc437c
Autor:
Daniele Boso, Martina Tognon, Matteo Curtarello, Sonia Minuzzo, Ilaria Piga, Valentina Brillo, Elisabetta Lazzarini, Jessica Carlet, Ludovica Marra, Chiara Trento, Andrea Rasola, Ionica Masgras, Leonardo Caporali, Fabio Del Ben, Giulia Brisotto, Matteo Turetta, Roberta Pastorelli, Laura Brunelli, Filippo Navaglia, Giovanni Esposito, Angela Grassi, Stefano Indraccolo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-19 (2023)
Abstract Background Genetic and metabolic heterogeneity are well-known features of cancer and tumors can be viewed as an evolving mix of subclonal populations, subjected to selection driven by microenvironmental pressures or drug treatment. In previo
Externí odkaz:
https://doaj.org/article/291e0ae6448e4b3eb631add9fd1a77cb
Autor:
Claudio Laquatra, Carlos Sanchez-Martin, Alberto Dinarello, Giuseppe Cannino, Giovanni Minervini, Elisabetta Moroni, Marco Schiavone, Silvio Tosatto, Francesco Argenton, Giorgio Colombo, Paolo Bernardi, Ionica Masgras, Andrea Rasola
Publikováno v:
Cell Death and Disease, Vol 12, Iss 5, Pp 1-14 (2021)
Abstract The mitochondrial paralog of the Hsp90 chaperone family TRAP1 is often induced in tumors, but the mechanisms controlling its expression, as well as its physiological functions remain poorly understood. Here, we find that TRAP1 is highly expr
Externí odkaz:
https://doaj.org/article/8e6dec8899704ed197fe94fdfa0442d0
Autor:
Carlos Sanchez-Martin, Elisabetta Moroni, Mariarosaria Ferraro, Claudio Laquatra, Giuseppe Cannino, Ionica Masgras, Alessandro Negro, Paolo Quadrelli, Andrea Rasola, Giorgio Colombo
Publikováno v:
Cell Reports, Vol 31, Iss 3, Pp - (2020)
Summary: TRAP1 is the mitochondrial paralog of the heat shock protein 90 (HSP90) chaperone family. Its activity as an energy metabolism regulator has important implications in cancer, neurodegeneration, and ischemia. Selective inhibitors of TRAP1 cou
Externí odkaz:
https://doaj.org/article/9fd14b74e0544bfaac1ed8890e0c77df
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4716 (2021)
Hexokinases are a family of ubiquitous exose-phosphorylating enzymes that prime glucose for intracellular utilization. Hexokinase 2 (HK2) is the most active isozyme of the family, mainly expressed in insulin-sensitive tissues. HK2 induction in most n
Externí odkaz:
https://doaj.org/article/d5c9a148ba6c4b42809ae37655aac76d
Autor:
Ionica Masgras, Francesco Ciscato, Anna Maria Brunati, Elena Tibaldi, Stefano Indraccolo, Matteo Curtarello, Federica Chiara, Giuseppe Cannino, Elena Papaleo, Matteo Lambrughi, Giulia Guzzo, Alberto Gambalunga, Marco Pizzi, Vincenza Guzzardo, Massimo Rugge, Stefania Edith Vuljan, Fiorella Calabrese, Paolo Bernardi, Andrea Rasola
Publikováno v:
Cell Reports, Vol 18, Iss 3, Pp 659-672 (2017)
Mutations in neurofibromin, a Ras GTPase-activating protein, lead to the tumor predisposition syndrome neurofibromatosis type 1. Here, we report that cells lacking neurofibromin exhibit enhanced glycolysis and decreased respiration in a Ras/ERK-depen
Externí odkaz:
https://doaj.org/article/5ef12b229fed44ec8de2df96396d1352
Autor:
Ionica Masgras, Giuseppe Cannino, Francesco Ciscato, Carlos Sanchez-Martin, Fereshteh Babaei Darvishi, Francesca Scantamburlo, Marco Pizzi, Alessio Menga, Dolores Fregona, Alessandra Castegna, Andrea Rasola
Publikováno v:
Cell Death & Differentiation. 29:1996-2008
Neurofibromin loss drives neoplastic growth and a rewiring of mitochondrial metabolism. Here we report that neurofibromin ablation dampens expression and activity of NADH dehydrogenase, the respiratory chain complex I, in an ERK-dependent fashion, de
Autor:
Francesca Zonta, Christian Borgo, Camila Paz Quezada Meza, Ionica Masgras, Andrea Rasola, Mauro Salvi, Lorenzo A. Pinna, Maria Ruzzene
Publikováno v:
Cells, Vol 10, Iss 1, p 181 (2021)
CK2 is a Ser/Thr protein kinase overexpressed in many cancers. It is usually present in cells as a tetrameric enzyme, composed of two catalytic (α or α’) and two regulatory (β) subunits, but it is active also in its monomeric form, and the speci
Externí odkaz:
https://doaj.org/article/25324a922bfd41e3bf4eb655bf940954
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Mitochondria are dynamic organelles that exchange a multiplicity of signals with other cell compartments, in order to finely adjust key biological routines to the fluctuating metabolic needs of the cell. During neoplastic transformation, cells must p
Externí odkaz:
https://doaj.org/article/2eff3305b7ee4a4eb276c553b512a3a4
Autor:
Andrea Rasola, Ionica Masgras
Publikováno v:
Clinical and Basic Aspects of Neurofibromatosis Type 1 ISBN: 9781839689628
Rewiring cellular metabolism is a key hallmark of cancer. Multiple evidences show that alterations in various metabolic circuits directly contribute to the tumorigenic process at different levels (e.g. cancer initiation, metastasis, resistance). Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f419557195aac5f50af0572ca269afd
https://doi.org/10.5772/intechopen.98661
https://doi.org/10.5772/intechopen.98661