Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Ionel, Sandovici"'
Autor:
Ionel Sandovici, Denise S. Fernandez-Twinn, Niamh Campbell, Wendy N. Cooper, Yoichi Sekita, Ilona Zvetkova, David Ferland-McCollough, Haydn M. Prosser, Lila M. Oyama, Lucas C. Pantaleão, Danilo Cimadomo, Karina Barbosa de Queiroz, Cecilia S.K. Cheuk, Nicola M. Smith, Richard G. Kay, Robin Antrobus, Katharina Hoelle, Marcella K.L. Ma, Noel H. Smith, Stefan H. Geyer, Lukas F. Reissig, Wolfgang J. Weninger, Kenneth Siddle, Anne E. Willis, Brian Y.H. Lam, Martin Bushell, Susan E. Ozanne, Miguel Constância
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114750- (2024)
Summary: Mir483 is a conserved and highly expressed microRNA in placental mammals, embedded within the Igf2 gene. Its expression is dysregulated in a number of human diseases, including metabolic disorders and certain cancers. Here, we investigate th
Externí odkaz:
https://doaj.org/article/abbc32c9c19d41bf953422abe96dc435
Autor:
Ionel Sandovici, Olatejumoye Knee, Jorge Lopez-Tello, Norman Shreeve, Abigail L. Fowden, Amanda N. Sferruzzi-Perri, Miguel Constância
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 8 (2024)
Externí odkaz:
https://doaj.org/article/445be47d9c0e4174abd213dcd58cb832
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101721- (2022)
Summary: In the mouse, feto-placental endothelial cells (FPEC) line the inner surface of the feto-placental blood vessels located within placental labyrinthine zone and play critical roles in placental development and function. Here, we present a det
Externí odkaz:
https://doaj.org/article/cdd374cacd114107aa082a4a36088459
Autor:
Tina Napso, Xiaohui Zhao, Marta Ibañez Lligoña, Ionel Sandovici, Richard G. Kay, Amy L. George, Fiona M. Gribble, Frank Reimann, Claire L. Meek, Russell S. Hamilton, Amanda N. Sferruzzi-Perri
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Napso et al. identify proteins from mouse placental endocrine cells and create a comprehensive secretome map of the placenta. The authors compare this secretome map with human placental datasets from women with pregnancy complications and demonstrate
Externí odkaz:
https://doaj.org/article/ff2b898ea1e54b2b8684c6ba582ddc31
Autor:
Ionel Sandovici, Constanze M. Hammerle, Sam Virtue, Yurena Vivas-Garcia, Adriana Izquierdo-Lahuerta, Susan E. Ozanne, Antonio Vidal-Puig, Gema Medina-Gómez, Miguel Constância
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract When exposed to nutrient excess and insulin resistance, pancreatic β-cells undergo adaptive changes in order to maintain glucose homeostasis. The role that growth control genes, highly expressed in early pancreas development, might exert in
Externí odkaz:
https://doaj.org/article/418fc450d39f40d4b1305155c0e3ac81
Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine
Autor:
Amber N. Ziegler, Qiang Feng, Shravanthi Chidambaram, Jaimie M. Testai, Ekta Kumari, Deborah E. Rothbard, Miguel Constancia, Ionel Sandovici, Tara Cominski, Kevin Pang, Nan Gao, Teresa L. Wood, Steven W. Levison
Publikováno v:
Stem Cell Reports, Vol 12, Iss 4, Pp 816-830 (2019)
Summary: Tissue-specific stem cells have unique properties and growth requirements, but a small set of juxtacrine and paracrine signals have been identified that are required across multiple niches. Whereas insulin-like growth factor II (IGF-II) is n
Externí odkaz:
https://doaj.org/article/37b18af9b7bb486e8adcbcdaf7f3aeae
Autor:
Sara Andrade, Tiago Morais, Ionel Sandovici, Alexandre L. Seabra, Miguel Constância, Mariana P. Monteiro
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
BackgroundObesity is a major risk factor for dysglycemic disorders, including type 2 diabetes (T2D). However, there is wide phenotypic variation in metabolic profiles. Tissue-specific epigenetic modifications could be partially accountable for the ob
Externí odkaz:
https://doaj.org/article/66eb519d070d4961bbb076a4811f91dc
Autor:
Constanze M Hammerle, Ionel Sandovici, Gemma V Brierley, Nicola M Smith, Warren E Zimmer, Ilona Zvetkova, Haydn M Prosser, Yoichi Sekita, Brian Y H Lam, Marcella Ma, Wendy N Cooper, Antonio Vidal-Puig, Susan E Ozanne, Gema Medina-Gómez, Miguel Constância
Publikováno v:
PLoS Genetics, Vol 16, Iss 10, p e1009069 (2020)
The genetic mechanisms that determine the size of the adult pancreas are poorly understood. Imprinted genes, which are expressed in a parent-of-origin-specific manner, are known to have important roles in development, growth and metabolism. However,
Externí odkaz:
https://doaj.org/article/dd9ff8b3a079402997344c273ba5478c
Autor:
Diogo Pestana, Diana Teixeira, Manuela Meireles, Cláudia Marques, Sónia Norberto, Carla Sá, Virgínia C. Fernandes, Luísa Correia-Sá, Ana Faria, Luísa Guardão, João T. Guimarães, Wendy N. Cooper, Ionel Sandovici, Valentina F. Domingues, Cristina Delerue-Matos, Rosário Monteiro, Miguel Constância, Conceição Calhau
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
Abstract Endocrine-disrupting chemicals such as p,p’-dichlorodiphenyldichloroethylene (p,p’-DDE), are bioaccumulated in the adipose tissue (AT) and have been implicated in the obesity and diabetes epidemic. Thus, it is hypothesized that p,p’-DD
Externí odkaz:
https://doaj.org/article/b3abd049ed6f4508bafbd0af443ec779
Autor:
Jorge López-Tello, Vicente Pérez-García, Jaspreet Khaira, Laura C Kusinski, Wendy N Cooper, Adam Andreani, Imogen Grant, Edurne Fernández de Liger, Brian YH Lam, Myriam Hemberger, Ionel Sandovici, Miguel Constancia, Amanda N Sferruzzi-Perri
Publikováno v:
eLife, Vol 8 (2019)
Studies suggest that placental nutrient supply adapts according to fetal demands. However, signaling events underlying placental adaptations remain unknown. Here we demonstrate that phosphoinositide 3-kinase p110α in the fetus and the trophoblast in
Externí odkaz:
https://doaj.org/article/57db7a58e0f24f85a79ce8d6453f5b04