A novel panel of short mononucleotide repeats linked to informative polymorphisms enabling effective high volume low cost discrimination between mismatch repair deficient and proficient tumours.

Autor: Lisa Redford, Ghanim Alhilal, Stephanie Needham, Ottie O'Brien, Julie Coaker, John Tyson, Leonardo Maldaner Amorim, Iona Middleton, Osagi Izuogu, Mark Arends, Anca Oniscu, Ángel Miguel Alonso, Sira Moreno Laguna, Richard Gallon, Harsh Sheth, Mauro Santibanez-Koref, Michael S Jackson, John Burn

Publikováno v: PLoS ONE, Vol 13, Iss 8, p e0203052 (2018)

Somatic mutations in mononucleotide repeats are commonly used to assess the mismatch repair status of tumours. Current tests focus on repeats with a length above 15bp, which tend to be somatically more unstable than shorter ones. These longer repeats

Externí odkaz: https://doaj.org/article/3e880ba13c9140f9962856f4f8dc8fd2

A novel panel of short mononucleotide repeats linked to informative polymorphisms enabling effective high volume low cost discrimination between mismatch repair deficient and proficient tumours

Autor: Richard Gallon, Osagi Izuogu, Leonardo Maldaner Amorim, Mauro Santibanez-Koref, Mark J. Arends, John Burn, Julie Coaker, Lisa Redford, Michael S. Jackson, Ottie O’Brien, Harsh Sheth, Sira Moreno Laguna, John R. Tyson, Anca Oniscu, Stephanie Needham, Ghanim Alhilal, Angel Alonso, Iona Middleton

Publikováno v: PLoS ONE, Vol 13, Iss 8, p e0203052 (2018)
Redford, L, Alhilal, G, Needham, S, O’Brien, O, Coaker, J, Tyson, J J, Maldaner Amorim, L, Middleton, I, Izuogu, O, Arends, M, Oniscu, A, Miguel Alonso, Á, Moreno Laguna, S, Gallon, R, Sheth, H, Santibanez-Koref, M, Jackson, M S & Burn, J 2018, ' A novel panel of short mononucleotide repeats linked to informative polymorphisms enabling effective high volume low cost discrimination between mismatch repair deficient and proficient tumours ', PLoS ONE . https://doi.org/10.1371/journal.pone.0203052

Somatic mutations in mononucleotide repeats are commonly used to assess the mismatch repair status of tumours. Current tests focus on repeats with a length above 15bp, which tend to be somatically more unstable than shorter ones. These longer repeats

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8080997be3d9ce533f72fb3d276a8b4
http://europepmc.org/articles/PMC6114912?pdf=render