Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Iona M MacLeod"'
Autor:
Jigme Dorji, Amanda J. Chamberlain, Coralie M. Reich, Christy J. VanderJagt, Tuan V. Nguyen, Hans D. Daetwyler, Iona M. MacLeod
Publikováno v:
Genetics Selection Evolution, Vol 56, Iss 1, Pp 1-9 (2024)
Abstract Background Mitochondrial genomes differ from the nuclear genome and in humans it is known that mitochondrial variants contribute to genetic disorders. Prior to genomics, some livestock studies assessed the role of the mitochondrial genome bu
Externí odkaz:
https://doaj.org/article/11ddd1817ea540619d315e0ce27dd31d
Autor:
Zexi Cai, Terhi Iso-Touru, Marie-Pierre Sanchez, Naveen Kadri, Aniek C. Bouwman, Praveen Krishna Chitneedi, Iona M. MacLeod, Christy J. Vander Jagt, Amanda J. Chamberlain, Birgit Gredler-Grandl, Mirjam Spengeler, Mogens Sandø Lund, Didier Boichard, Christa Kühn, Hubert Pausch, Johanna Vilkki, Goutam Sahana
Publikováno v:
Genetics Selection Evolution, Vol 56, Iss 1, Pp 1-22 (2024)
Abstract Background Mastitis is a disease that incurs significant costs in the dairy industry. A promising approach to mitigate its negative effects is to genetically improve the resistance of dairy cattle to mastitis. A meta-analysis of genome-wide
Externí odkaz:
https://doaj.org/article/0b518444be7b41d0b9f36f33a691ad7e
Autor:
Irene van den Berg, Amanda J. Chamberlain, Iona M. MacLeod, Tuan V. Nguyen, Mike E. Goddard, Ruidong Xiang, Brett Mason, Susanne Meier, Claire V. C. Phyn, Chris R. Burke, Jennie E. Pryce
Publikováno v:
Genetics Selection Evolution, Vol 56, Iss 1, Pp 1-18 (2024)
Abstract Background Female fertility is an important trait in dairy cattle. Identifying putative causal variants associated with fertility may help to improve the accuracy of genomic prediction of fertility. Combining expression data (eQTL) of genes,
Externí odkaz:
https://doaj.org/article/eb916b93e29a4197bc37af791abba3ff
Autor:
Oscar Gonzalez-Recio, Hans D Daetwyler, Iona M MacLeod, Jennie E Pryce, Phil J Bowman, Ben J Hayes, Michael E Goddard
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143945 (2015)
The proportion of genetic variation in complex traits explained by rare variants is a key question for genomic prediction, and for identifying the basis of "missing heritability"--the proportion of additive genetic variation not captured by common va
Externí odkaz:
https://doaj.org/article/a8483c3228154c3abfa24894305e03ba
Autor:
Ruidong Xiang, Lingzhao Fang, Shuli Liu, Iona M. Macleod, Zhiqian Liu, Edmond J. Breen, Yahui Gao, George E. Liu, Albert Tenesa, Brett A. Mason, Amanda J. Chamberlain, Naomi R. Wray, Michael E. Goddard
Publikováno v:
Cell Genomics, Vol 3, Iss 10, Pp 100385- (2023)
Summary: Many quantitative trait loci (QTLs) are in non-coding regions. Therefore, QTLs are assumed to affect gene regulation. Gene expression and RNA splicing are primary steps of transcription, so DNA variants changing gene expression (eVariants) o
Externí odkaz:
https://doaj.org/article/97272e77d4a5469f8c556d16c5b5034e
Autor:
Tuan V. Nguyen, Christy J. Vander Jagt, Jianghui Wang, Hans D. Daetwyler, Ruidong Xiang, Michael E. Goddard, Loan T. Nguyen, Elizabeth M. Ross, Ben J. Hayes, Amanda J. Chamberlain, Iona M. MacLeod
Publikováno v:
Genetics Selection Evolution, Vol 55, Iss 1, Pp 1-15 (2023)
Abstract Studies have demonstrated that structural variants (SV) play a substantial role in the evolution of species and have an impact on Mendelian traits in the genome. However, unlike small variants (
Externí odkaz:
https://doaj.org/article/659b18ddcf7241ca859ede196b0ba0f0
Publikováno v:
Frontiers in Animal Science, Vol 4 (2023)
Selection decisions are generally based on estimated breeding values (EBV) for a combination of traits that are polygenic (e.g. milk production). However, in some cases, there is additional intense selection for a single allele, or SNP, for a perceiv
Externí odkaz:
https://doaj.org/article/ec1c49fc7a0e44768f9cbdbc87ca1a8e
Autor:
Irene van den Berg, Phuong N. Ho, Tuan V. Nguyen, Mekonnen Haile-Mariam, Iona M. MacLeod, Phil R. Beatson, Erin O’Connor, Jennie E. Pryce
Publikováno v:
Genetics Selection Evolution, Vol 54, Iss 1, Pp 1-12 (2022)
Abstract Background Urinary nitrogen leakage is an environmental concern in dairy cattle. Selection for reduced urinary nitrogen leakage may be done using indicator traits such as milk urea nitrogen (MUN). The result of a previous study indicated tha
Externí odkaz:
https://doaj.org/article/390c94262b33418b9ff93d6d6af0c692
Autor:
Evans K. Cheruiyot, Mekonnen Haile-Mariam, Benjamin G. Cocks, Iona M. MacLeod, Raphael Mrode, Jennie E. Pryce
Publikováno v:
Genetics Selection Evolution, Vol 54, Iss 1, Pp 1-18 (2022)
Abstract Background Heat tolerance is a trait of economic importance in the context of warm climates and the effects of global warming on livestock production, reproduction, health, and well-being. This study investigated the improvement in predictio
Externí odkaz:
https://doaj.org/article/01b43b530611454bb9c1271bfbfba465
Autor:
Ruidong Xiang, Ed J. Breen, Sunduimijid Bolormaa, Christy J. Vander Jagt, Amanda J. Chamberlain, Iona M. Macleod, Michael E. Goddard
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Xiang and colleagues infer mutant alleles in 113,000 cattle to quantify the effect of these mutations on complex traits including body size, fertility and milk production, and compare these mutation sites across 100 species of vertebrates. Some sites
Externí odkaz:
https://doaj.org/article/ac274d4ccede445195d2879e2b1c1b66