Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Iona M, MacLeod"'
Autor:
Tuan V. Nguyen, Sunduimijid Bolormaa, Coralie M. Reich, Amanda J. Chamberlain, Christy J. Vander Jagt, Hans D. Daetwyler, Iona M. MacLeod
Publikováno v:
Genetics Selection Evolution, Vol 56, Iss 1, Pp 1-14 (2024)
Abstract Background Genotype imputation is a cost-effective method for obtaining sequence genotypes for downstream analyses such as genome-wide association studies (GWAS). However, low imputation accuracy can increase the risk of false positives, so
Externí odkaz:
https://doaj.org/article/e626f943e7ba479aafdd42173336d620
Autor:
Jigme Dorji, Amanda J. Chamberlain, Coralie M. Reich, Christy J. VanderJagt, Tuan V. Nguyen, Hans D. Daetwyler, Iona M. MacLeod
Publikováno v:
Genetics Selection Evolution, Vol 56, Iss 1, Pp 1-9 (2024)
Abstract Background Mitochondrial genomes differ from the nuclear genome and in humans it is known that mitochondrial variants contribute to genetic disorders. Prior to genomics, some livestock studies assessed the role of the mitochondrial genome bu
Externí odkaz:
https://doaj.org/article/11ddd1817ea540619d315e0ce27dd31d
Autor:
Zexi Cai, Terhi Iso-Touru, Marie-Pierre Sanchez, Naveen Kadri, Aniek C. Bouwman, Praveen Krishna Chitneedi, Iona M. MacLeod, Christy J. Vander Jagt, Amanda J. Chamberlain, Birgit Gredler-Grandl, Mirjam Spengeler, Mogens Sandø Lund, Didier Boichard, Christa Kühn, Hubert Pausch, Johanna Vilkki, Goutam Sahana
Publikováno v:
Genetics Selection Evolution, Vol 56, Iss 1, Pp 1-22 (2024)
Abstract Background Mastitis is a disease that incurs significant costs in the dairy industry. A promising approach to mitigate its negative effects is to genetically improve the resistance of dairy cattle to mastitis. A meta-analysis of genome-wide
Externí odkaz:
https://doaj.org/article/0b518444be7b41d0b9f36f33a691ad7e
Autor:
Irene van den Berg, Amanda J. Chamberlain, Iona M. MacLeod, Tuan V. Nguyen, Mike E. Goddard, Ruidong Xiang, Brett Mason, Susanne Meier, Claire V. C. Phyn, Chris R. Burke, Jennie E. Pryce
Publikováno v:
Genetics Selection Evolution, Vol 56, Iss 1, Pp 1-18 (2024)
Abstract Background Female fertility is an important trait in dairy cattle. Identifying putative causal variants associated with fertility may help to improve the accuracy of genomic prediction of fertility. Combining expression data (eQTL) of genes,
Externí odkaz:
https://doaj.org/article/eb916b93e29a4197bc37af791abba3ff
Autor:
Tuan V. Nguyen, Christy J. Vander Jagt, Jianghui Wang, Hans D. Daetwyler, Ruidong Xiang, Michael E. Goddard, Loan T. Nguyen, Elizabeth M. Ross, Ben J. Hayes, Amanda J. Chamberlain, Iona M. MacLeod
Publikováno v:
Genetics Selection Evolution, Vol 55, Iss 1, Pp 1-15 (2023)
Abstract Studies have demonstrated that structural variants (SV) play a substantial role in the evolution of species and have an impact on Mendelian traits in the genome. However, unlike small variants (
Externí odkaz:
https://doaj.org/article/659b18ddcf7241ca859ede196b0ba0f0
Autor:
Ruidong Xiang, Lingzhao Fang, Shuli Liu, Iona M. Macleod, Zhiqian Liu, Edmond J. Breen, Yahui Gao, George E. Liu, Albert Tenesa, Brett A. Mason, Amanda J. Chamberlain, Naomi R. Wray, Michael E. Goddard
Publikováno v:
Cell Genomics, Vol 3, Iss 10, Pp 100385- (2023)
Summary: Many quantitative trait loci (QTLs) are in non-coding regions. Therefore, QTLs are assumed to affect gene regulation. Gene expression and RNA splicing are primary steps of transcription, so DNA variants changing gene expression (eVariants) o
Externí odkaz:
https://doaj.org/article/97272e77d4a5469f8c556d16c5b5034e
Autor:
Sunduimijid Bolormaa, Iona M. MacLeod, Majid Khansefid, Leah C. Marett, William J. Wales, Filippo Miglior, Christine F. Baes, Flavio S. Schenkel, Erin E. Connor, Coralia I. V. Manzanilla-Pech, Paul Stothard, Emily Herman, Gert J. Nieuwhof, Michael E. Goddard, Jennie E. Pryce
Publikováno v:
Genetics Selection Evolution, Vol 54, Iss 1, Pp 1-17 (2022)
Abstract Background Sharing individual phenotype and genotype data between countries is complex and fraught with potential errors, while sharing summary statistics of genome-wide association studies (GWAS) is relatively straightforward, and thus woul
Externí odkaz:
https://doaj.org/article/1fd8f15c792044cc9755c1186e0c3c46
Autor:
Edmond J. Breen, Iona M. MacLeod, Phuong N. Ho, Mekonnen Haile-Mariam, Jennie E. Pryce, Carl D. Thomas, Hans D. Daetwyler, Michael E. Goddard
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
BayesR3 samples the polymorphisms affecting complex traits at reduced computational cost to predict the genetic value, breeding value, or individual risk of genotypes.
Externí odkaz:
https://doaj.org/article/06ac910dadaf495d8e49b76d5bef4285
Autor:
Jigme Dorji, Christy J. Vander Jagt, Amanda J. Chamberlain, Benjamin G. Cocks, Iona M. MacLeod, Hans D. Daetwyler
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Maternal diversity based on a sub-region of mitochondrial genome or variants were commonly used to understand past demographic events in livestock. Additionally, there is growing evidence of direct association of mitochondrial genetic varian
Externí odkaz:
https://doaj.org/article/4b6d0718042b4e3ab9f643130b1255df
Autor:
Irene van den Berg, Phuong N. Ho, Tuan V. Nguyen, Mekonnen Haile-Mariam, Iona M. MacLeod, Phil R. Beatson, Erin O’Connor, Jennie E. Pryce
Publikováno v:
Genetics Selection Evolution, Vol 54, Iss 1, Pp 1-12 (2022)
Abstract Background Urinary nitrogen leakage is an environmental concern in dairy cattle. Selection for reduced urinary nitrogen leakage may be done using indicator traits such as milk urea nitrogen (MUN). The result of a previous study indicated tha
Externí odkaz:
https://doaj.org/article/390c94262b33418b9ff93d6d6af0c692