Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Ion channel signalling"'
Autor:
Maren Lindner, Tobias Bopp, Stefanie Bock, Steffen Pfeuffer, Felix Luessi, Sven G. Meuth, Jochen Huehn, Thomas Pap, Marc Pawlitzki, Stefan Bittner, Marie Liebmann, Paul Marciniak, Leoni Rolfes, Stjepana Kovac, Johannes Roth, Gerd Meyer zu Hörste, Nils Opel, Patricia Seja, Derya Cengiz, Alexander M Herrmann, Achmet Imam Chasan, Stefan Floess, Tim Hahn, Luisa Klotz, Tobias Marschall, Björn Tackenberg, Erhard Wischmeyer, Thomas Budde, Julian A. Schreiber, Udo Dannlowski, Bernhard Wünsch, Tanja Kuhlmann, Christina B Schroeter, Heinz Wiendl, Tobias Ruck, Frank Döring, Guiscard Seebohm, Lukas Gola
Publikováno v:
Cell Research
It remains largely unclear how thymocytes translate relative differences in T cell receptor (TCR) signal strength into distinct developmental programs that drive the cell fate decisions towards conventional (Tconv) or regulatory T cells (Treg). Follo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca262f544366b983281a0eb149ac9be
https://doi.org/10.1038/s41422-021-00580-z
https://doi.org/10.1038/s41422-021-00580-z
Autor:
Yang Sun, Hui-Nan Zhang, Wen Tian, Wei Cao, Xiao-Qiang Li, Shou-Jia Wang, Chen Ye, Yuan-Yuan Gao, Guang-Yuan Ma, Ying-Da Feng, Wen Ye
Publikováno v:
Oncogenesis, Vol 10, Iss 10, Pp 1-13 (2021)
Oncogenesis
Oncogenesis
Transient receptor potential canonical (TRPC) channels are the most prominent nonselective cation channels involved in various diseases. However, the function, clinical significance, and molecular mechanism of TRPCs in colorectal cancer (CRC) progres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ac4df245d04cf829a5d91752793aab
https://doaj.org/article/581e687c7a6949f8a3c44bf28b6627d7
https://doaj.org/article/581e687c7a6949f8a3c44bf28b6627d7
Autor:
Zhen Yan, Dong Deng, Qiang Su, Jianping Wu, Shirong Lai, Yue Yu, Jia Geng, Changjian Zhao, Wei-Zheng Zeng, Lina Yang, Kun Wu, Meng Ke, Weidan Yuan
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-4 (2021)
Cell Discovery
Cell Discovery
TMEM120A (Transmembrane protein 120A) was recently identified as a mechanical pain sensing ion channel named as TACAN, while its homologue TMEM120B has no mechanosensing property1. Here, we report the cryo-EM structures of both human TMEM120A and TME
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c957ea499b3497cfb0b7b8a0a720465e
https://doaj.org/article/005dfdc28fd346d9b93c3d5e41ac09ac
https://doaj.org/article/005dfdc28fd346d9b93c3d5e41ac09ac
Autor:
Keisuke Goda, Xunbin Wei, Xiaoying Tian, Hua Feng, Youjun Wang, Hao He, Juan Cheng, Tunan Chen, Pan Cheng, Wanyi Tang, Tian Xue, Haipeng Wang, Sisi Zheng, Jin Bao
Publikováno v:
Cell Research
Ca2+ channels are essential to cell birth, life, and death. They can be externally activated by optogenetic tools, but this requires robust introduction of exogenous optogenetic genes for expression of photosensitive proteins in biological systems. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d334cc54e75a80ea7f39172ad2742b63
http://europepmc.org/articles/PMC8249419
http://europepmc.org/articles/PMC8249419
Autor:
Miguel Martín-Aragón Baudel, Peter Bartels, Madeline Nieves-Cintrón, Víctor A. Flores-Tamez, Kent C. Sasse, Nipavan Chiamvimonvat, Johannes W. Hell, G. R. Reddy, John D. Scott, Luis Fernando Santana, Arsalan U. Syed, Eamonn J. Dickson, Maria Paz Prada, Sean M. Ward, Padmini Sirish, Yang Kevin Xiang, Manuel F. Navedo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
The L-type Ca2+ channel CaV1.2 is essential for arterial myocyte excitability, gene expression and contraction. Elevations in extracellular glucose (hyperglycemia) potentiate vascular L-type Ca2+ channel via PKA, but the underlying mechanisms are unc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82eb0ff076a26f37a5821e35c2f5b808
http://link.springer.com/article/10.1038/s41467-020-18947-y
http://link.springer.com/article/10.1038/s41467-020-18947-y
Autor:
Thomas W. White, Virginijus Valiunas
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports
Scientific Reports
Gap junction channels made of different connexins have distinct permeability to second messengers, which could affect many cell processes, including lens epithelial cell division. Here, we have compared the permeability of IP3 and Ca2+ through channe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd937b45bb8a60eee3c0955b95f0a633
http://link.springer.com/article/10.1038/s41598-020-65761-z
http://link.springer.com/article/10.1038/s41598-020-65761-z
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
The purpose of this study was to determine if transient cell membrane disruptions (TPMDs) in single keratocytes can trigger signaling events in neighboring keratocytes. Stromal cells were cultured from human corneas (HCSC) and mouse corneas (MCSC). T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db1b3977955171c2c2fc43041fae4e6
http://link.springer.com/article/10.1038/s41598-020-59570-7
http://link.springer.com/article/10.1038/s41598-020-59570-7
Autor:
Anna Pegoraro, Elena Adinolfi, Cristian Bassi, Elisa Orioli, Michele Zanoni, Massimo Negrini, Manuela Ferracin, Elena De Marchi, Francesco Di Virgilio, Emi Dika, Anna Tesei, Marina Capece
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 12, Pp 1-12 (2021)
Cell Death and Disease, Vol 12, Iss 12, Pp 1-12 (2021)
Tumor growth and metastatic spreading are heavily affected by the P2X7 receptor as well as microvesicles and exosomes release into the tumor microenvironment. P2X7 receptor stimulation is known to trigger vesicular release from immune and central ner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fcb4034b80d3c6df4d7adf8ee3d3925
http://europepmc.org/articles/PMC8599616
http://europepmc.org/articles/PMC8599616
Publikováno v:
Cell Death Discovery
Cell Death Discovery, Vol 7, Iss 1, Pp 1-14 (2021)
Cell Death Discovery, Vol 7, Iss 1, Pp 1-14 (2021)
The purpose of this study was to investigate whether inhibition of DNA (cytosine-5)-methyltransferase 1 (DNMT-1) alleviated ferroptosis through nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy during diabetes myocardial (DM) ischemia/re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fddc311ca041ed8bd21affd9815ac0e
https://doi.org/10.1038/s41420-021-00656-0
https://doi.org/10.1038/s41420-021-00656-0
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 7, Pp 1-11 (2019)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Chloride intracellular channel 1 (CLIC1) is a promising therapeutic target in cancer due to its intrinsic characteristics; it is overexpressed in specific tumor types and its localization changes from cytosolic to surface membrane depending on activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a243aec5b1ececc128b4074f6e2874f3
https://doaj.org/article/2339d991524942a5a3cae1eff63f1225
https://doaj.org/article/2339d991524942a5a3cae1eff63f1225